# SkinCeuticals P-TOX for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [SkinCeuticals](https://lovi.care/skincare/es/brands/skinceuticals)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, the Advanced Peptide Complex and Hexapeptide work to improve skin volume and elasticity, while Niacinamide offers anti-inflammatory benefits to address redness and irritation.
- PHA provides mild keratolytic action, further supporting skin texture and clarity for your normal skin type.
- The product is safe for your sensitive skin, with no risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/oily-acne-prone-skin): High

## Key ingredients

Advanced Peptide Complex, Hexapeptide, Niacinamide, Laminaria Digitata Extract

## What the research says

- Postresurfacing use of a tripeptide/hexapeptide system improved healing, reduced erythema, exudation, tenderness, and burning/stinging, and increased subject satisfaction compared to a bland ointment and cream in 14 female subjects following facial laser resurfacing. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/))
- A peptide complex stimulated basement membrane protein expressions and significantly improved skin wrinkles at all five measured sites after two weeks in 22 healthy Asian female volunteers older than 40 years. ([International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/))
- Adding a tripeptide/hexapeptide anhydrous gel pre- and post-procedure to a topical body treatment significantly reduced patient-reported scores of skin edema, induration, and subcutaneous fibrous banding compared to the body treatment alone in 10 female patients undergoing neck and body contouring procedures. ([Aesthetic Surgery Journal. Open Forum, 2021](https://pubmed.ncbi.nlm.nih.gov/33791673/))
- Topical tripeptide/hexapeptide formulations (RSN and TFB) applied around medial thigh liposuction accelerated healing, reduced induration, edema, and fluid infiltration, and improved extracellular matrix remodeling compared to a bland moisturizer. ([Aesthetic Surgery Journal. Open Forum, 2021](https://pubmed.ncbi.nlm.nih.gov/33791675/))
- Peri-procedural application of a tripeptide/hexapeptide serum as an adjunct to nonablative fractional laser resurfacing resulted in greater clinical improvements in photodamage and cutaneous aging compared to a bland moisturizer in 20 subjects. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33051975/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38922798/))
- Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38041526/))
- Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir. ([Frontiers in Microbiology, 2020](https://pubmed.ncbi.nlm.nih.gov/33013743/))

## What reviewers say

Based on a very large amount of data, this anti-aging peptide serum and cream duo is highly rated for targeting expression lines, deep-set wrinkles, and uneven skin texture. Users frequently report achieving a radiant, smooth, and hydrated complexion. Some users note that it may take time to see results on deeper wrinkles, and a few experienced breakouts. The high price point is also a common consideration.

- Liked: Smoother skin (mostly mentioned)
- Liked: Hydrating and light (often mentioned)
- Liked: Reduces lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Complements Botox (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SkinCeuticals P-TOX a great fit for sensitive skin?

SkinCeuticals P-TOX is a great fit because it is safe for sensitive skin without harsh ingredients that might cause irritation, while Niacinamide helps calm redness. Advanced Peptide Complex and Hexapeptide work to improve skin volume and elasticity, and PHA gently smooths texture and clarity.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### Which ingredients make this treatment a good fit for sensitive skin?

This treatment is a great fit for sensitive skin because it features Niacinamide to calm redness and irritation, along with Advanced Peptide Complex and Hexapeptide to improve skin volume and elasticity safely. PHA also gently supports skin texture without harshness, making it very unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Peptide Complex do for sensitive skin?

A peptide complex helps smooth wrinkles and supports skin firmness for sensitive skin. These ingredients improve hydration and stimulate key proteins to help strengthen the skin over time.
Sources: [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/), [Frontiers in Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/41924746/)

### What does Hexapeptide do for sensitive skin?

Hexapeptide helps smooth out fine lines and reduce skin roughness when used regularly. It is unlikely to cause irritation and may improve overall skin texture over several weeks.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40196961/)

### Where does it go in a skincare routine for sensitive skin?

This treatment goes in your evening routine, applied after your cleanser and soothing toner and before your moisturizer. Using it at night keeps it simple and safe, and it is unlikely to irritate your sensitive skin because it lacks harsh ingredients.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying the retinol first and following it with this product in your evening routine. This helps keep skin smooth and firm while keeping redness and irritation unlikely, as the formula contains soothing ingredients and lacks harsh additives.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### How often should I use it?

This treatment is a great fit for your sensitive skin and is best used in the evening once a week to start. Because it is gentle and free of harsh ingredients, you may carefully use it more often if your skin tolerates it well.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### Can it clog pores, cause breakouts or purging for sensitive skin?

This treatment is unlikely to cause breakouts on sensitive skin, as its formula avoids harsh ingredients that typically trigger irritation. Reviewers rarely mention breakouts, and the product is considered a great fit for keeping skin calm and clear.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.80 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/es/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.13 at Amazon

## Where to buy

- Amazon.de: €150.00 (https://www.amazon.de/dp/B0FPFJ16KT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €155.25 (https://www.lookfantastic.es/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/)
Prices checked 16 Oct – 6 Nov 2026.

## Ingredients

Advanced Peptide Complex, Hexapeptide, Dipeptide, Pha, Niacinamide, Laminaria Digitata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinceuticals/p-tox/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinceuticals/p-tox/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/skinceuticals/p-tox/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/skinceuticals/p-tox/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/skinceuticals/p-tox/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/skinceuticals/p-tox/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinceuticals/p-tox/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/skinceuticals/p-tox/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinceuticals/p-tox/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinceuticals/p-tox/for/sensitive-skin