SkinCeuticals P-TOX for dry skin
Advanced Peptide Complex
Hexapeptide
Niacinamide
Laminaria Digitata Extract
High
- HighDry Skin Fit
- HighEffectiveness
- HighSafety
A great choice for dry skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers high suitability for your dry skin as the Advanced Peptide Complex and Hexapeptide stimulate collagen and repair your skin barrier, addressing dryness and flakiness. Niacinamide further supports barrier function and soothes irritation.
- The Dipeptide and Pha contribute to excellent plumping and firming effects, enhancing visible anti-aging benefits for your skin.
- The formula is safe for your dry skin, containing no harsh ingredients and including soothing components like Niacinamide.
How to apply
- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.4Overall rating based on 2.1k+ reviewsBased on a very large amount of data, this anti-aging peptide serum and cream duo is highly rated for targeting expression lines, deep-set wrinkles, and uneven skin texture. Users frequently report achieving a radiant, smooth, and hydrated complexion. Some users note that it may take time to see results on deeper wrinkles, and a few experienced breakouts. The high price point is also a common consideration.
Highlights
Smoother skin Mostly Mentioned
- “definitely gave me a glass skin texture”
- “pores appeared less noticeable after just a few days”
- “increase of smooth skin”
- “skin looks more radiant and smoother”
Hydrating and light Often Mentioned
- “absorbs into my skin quickly”
- “leaves my skin feeling moisturised and glowing”
- “absorbs super quickly”
- “silky, non-greasy, and layers beautifully”
Reduces lines Often Mentioned
- “reduction in some of the finer lines”
- “fine lines around my eyes... fading”
- “crow's feet and my smile lines... became smoother”
- “noticeable reduction in the depth of my wrinkles”
High price point Often Mentioned
- “Too pricey for the hype”
- “It's a bit on the pricey side”
- “Expensive but worth it”
Complements Botox Sometimes Noted
- “really help maintain my Botox”
- “keeps my skin firm, smooth”
- “Great after Botox”
- “prolong the results between visits”
Slow results Sometimes Noted
- “haven't noticed much change on the deeper lines”
- “noticed no changes at all”
- “changes that I did notice were very subtle”
- “one bottle won't eliminate the need for Botox”
Causes breakouts Rarely Noted
- “skin went through a slight purge”
- “my skin had so many whiteheads”
- “Broke out the first week”
- “Something is causing me to breakout”
Sources: lovi.care, dermstore.com, lovelyskin.com, lookfantastic.com, ellemesmedspa.com, reddit.com, and more
Questions and answers
What makes SkinCeuticals P-TOX a great fit for dry skin?
SkinCeuticals P-TOX is a great fit because its Advanced Peptide Complex and Hexapeptide stimulate collagen and repair your skin barrier, which addresses dryness and flakiness. Niacinamide further supports barrier function and soothes irritation, while the Dipeptide and PHA provide great plumping and firming effects.
Annals of Dermatology, 2019International Journal of Molecular Sciences, 2019
Which ingredients make this treatment a good fit for dry skin?
Advanced Peptide Complex, Hexapeptide, and Niacinamide make this treatment a great fit for your dry skin by stimulating collagen, repairing your skin barrier, and soothing irritation. Laminaria Digitata Extract further helps address dryness and flakiness while keeping your skin feeling soft and smooth.
Annals of Dermatology, 2019International Journal of Molecular Sciences, 2019
What does Peptide Complex do for dry skin?
A peptide complex helps smooth out skin wrinkles and supports your skin when it is dry. This type of product needs nourishing ingredients and moisture-locking components to help repair and hydrate dry skin effectively.
What does Hexapeptide do for dry skin?
Hexapeptide helps hydrate dry skin and smooth out fine lines when you use it regularly in your routine. It also improves skin elasticity so your face feels softer and looks firmer.
Annals of Dermatology, 2019International Journal of Molecular Sciences, 2025
Where does this treatment go in a skincare routine for dry skin?
This treatment goes in the evening routine for dry skin after cleansing and before your moisturizer. Applying treatments at night helps support your skin barrier while keeping things simple and safe around sun exposure.
Can I use it with retinol, and in what order?
You can use this treatment with retinol by applying your retinol first and following with this formula in your evening routine. This helps keep your dry skin comfortable while delivering the smoothing and firming benefits of the Advanced Peptide Complex and Hexapeptide.
Annals of Dermatology, 2019International Journal of Molecular Sciences, 2019
How often should I use it?
Use this treatment in the evening as part of your routine, applying it after cleansing and before your moisturizer. This timing keeps your routine simple and adds extra safety around sun exposure.
Can this treatment clog pores, cause breakouts or purging for dry skin?
This treatment is unlikely to cause breakouts for dry skin as it contains no harsh ingredients and features soothing Niacinamide to keep skin calm.
What the research says
Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019A peptide complex stimulated basement membrane protein expressions and significantly improved skin wrinkles at all five measured sites after two weeks in 22 healthy Asian female volunteers older than 40 years.
International Journal of Molecular Sciences, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Postresurfacing use of a tripeptide/hexapeptide system improved healing, reduced erythema, exudation, tenderness, and burning/stinging, and increased subject satisfaction compared to a bland ointment and cream in 14 female subjects following facial laser resurfacing.
Journal of Cosmetic Dermatology, 2017Adding a tripeptide/hexapeptide anhydrous gel pre- and post-procedure to a topical body treatment significantly reduced patient-reported scores of skin edema, induration, and subcutaneous fibrous banding compared to the body treatment alone in 10 female patients undergoing neck and body contouring procedures.
Aesthetic Surgery Journal. Open Forum, 2021Topical tripeptide/hexapeptide formulations (RSN and TFB) applied around medial thigh liposuction accelerated healing, reduced induration, edema, and fluid infiltration, and improved extracellular matrix remodeling compared to a bland moisturizer.
Aesthetic Surgery Journal. Open Forum, 2021Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction.
Journal of Cosmetic Dermatology, 2024Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery.
Journal of Cosmetic Dermatology, 2023Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir.
Frontiers in Microbiology, 2020
Ingredients
Advanced Peptide Complex, Hexapeptide, Dipeptide, Pha, Niacinamide, Laminaria Digitata Extract
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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