# Sesderma Azelac RU Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Sesderma](https://lovi.care/skincare/es/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent brightening and evening of skin tone for your combination skin is provided by 4-butylresorcinol and azelaic acid, which effectively inhibit melanin production and offer seboregulation.
- Targeted benefits for your acne, blemishes, and breakouts are delivered through azelaic acid and retinol, addressing hyperpigmentation and inflammation while niacinamide further soothes.
- The formulation is safe for your acne-prone skin, as it lacks prohibited or harsh ingredients and carries no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Liposomal Azelaic Acid, 4-Butylresorcinol, Tranexamic Acid, Niacinamide, Retinol

## What the research says

- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4. ([Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/))
- Azelaic acid 15% gel showed comparable efficacy to adapalene 0.1% gel in reducing lesions, severity, and Dermatology Life Quality Index in women with adult acne, with significantly lower dryness and scaling, and demonstrated superiority during maintenance compared to no further treatment. ([Journal of the European Academy of Dermatology and Venereology, 2015](https://pubmed.ncbi.nlm.nih.gov/25399481/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))

## What reviewers say

Users report this serum effectively brightens the complexion and fades post-acne marks and sunspots, often showing visible results within a few weeks. It is praised for its lightweight texture and ability to control mild acne, though some users note it requires patience for older, deeper pigmentation and can be slightly drying.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Brightens skin tone (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Controls acne (sometimes noted)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Drying effect (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Sesderma Azelac RU a great fit for acne-prone skin?

Sesderma Azelac RU Serum is a great fit for acne-prone skin because azelaic acid and retinol target blemishes and breakouts while reducing inflammation and dark spots. Niacinamide further soothes the skin, and the formula is safe and unlikely to cause irritation.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Which ingredients make this serum a good fit for acne-prone skin?

Liposomal Azelaic Acid, 4-Butylresorcinol, Tranexamic Acid, Niacinamide, and Retinol make this serum a great fit for your acne-prone skin. Azelaic acid and retinol help target breakouts and blemishes while soothing inflammation, and 4-butylresorcinol effectively evens skin tone.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### What does Azelaic Acid do for acne-prone skin?

Azelaic acid helps calm acne-prone skin by reducing inflammation, clearing bacteria, and preventing clogged pores. It also may fade dark spots left behind by breakouts to keep your skin tone even and smooth.
Sources: [Skin Pharmacology and Physiology, 2014](https://pubmed.ncbi.nlm.nih.gov/24280644/), [Postepy Dermatologii I Alergologii, 2023](https://pubmed.ncbi.nlm.nih.gov/38282869/)

### What does 4-Butylresorcinol do for acne-prone skin?

4-Butylresorcinol is not a direct fit for acne-prone skin, as it targets dark spots and uneven tone rather than breakouts or clogged pores. Skin prone to breakouts needs ingredients that clear pores, soothe redness, and gently remove dead skin cells.

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in your evening routine as a treatment step, used after cleansing and toning and before moisturizing. Putting treatments in the evening keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this serum with AHA, and in what order?

You can use this serum with AHAs, but it is best to use them on alternate nights to keep your skin calm and avoid irritation from combining strong ingredients.

### How often should I use this serum?

Use this serum in your evening routine, applying it once a week at first and slowly increasing the frequency as your skin feels comfortable. This helps your acne-prone skin receive the active ingredients safely while reducing the likelihood of irritation.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

Sesderma Azelac RU Serum is a great fit for acne-prone skin because its ingredients target blemishes and inflammation while keeping irritation unlikely. Azelaic acid and retinol help clear breakouts, and niacinamide calms the skin without clogging pores.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol).

## Alternatives for acne-prone skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — €29.76 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €17.49 at Amazon

## Where to buy

- Amazon.de: €35.16 (https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €46.00 (https://www.notino.es/sesderma/azelac-ru/p-514983/)
Prices checked 17 Oct – 6 Nov 2026.

## Ingredients

Water, Propylene Glycol, Alcohol, Peg Ppg-20 6 Dimethicone, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, 4-Butylresorcinol, Azelaic Acid, Retinol, Ascorbyl Glucoside, Niacin, Undecylenoyl Phenylalanine, Glycyrrhetinic Acid, Diacetyl Boldine, Citronellyl Methylcrotonate, Sodium Oxalate, Parfum, Carbomer, Xanthan Gum, Tocopheryl Acetate, Polysorbate 20, Bht, Ethylhexylglycerin, Sodium Hydroxide, Caprylic Capric Triglyceride, Sodium Chloride, Bha, Hydrochloric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/acne-prone-skin