# ROUND LAB Pine Calming Cica Ampoule for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [ROUND LAB](https://lovi.care/skincare/es/brands/round-lab)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin due to the presence of Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid, which provide excellent humectant action and barrier strengthening.
- The inclusion of Asiaticoside, Madecassoside, and Madecasic Acid offers calming benefits, while Capryloyl Salicylic Acid provides mild exfoliation to moderately address pigmentation.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Pine Extract, Centella Asiatica Extract, Sodium Hyaluronate, Glycerin, Madecassoside

## What the research says

- Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability. ([Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/))
- Polyelectrolyte nanocomplexes of quaternized cyclodextrin grafted chitosan and low molecular weight hyaluronic acid improved skin texture and elasticity by increasing skin hydration in clinical evaluation. ([Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/))
- Capryloyl salicylic acid peel reduced fine lines, wrinkles, and hyperpigmentation comparably to glycolic acid peel in 44 female volunteers, with no statistically significant differences between the two treatments. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146601/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- A xanthan gum and alginate-based bioadhesive film loaded with pycnogenol provides sustained drug release within 24 hours, achieves a safe maximum concentration of ~ 0.2 mg/mL for keratinocytes, and absorbs simulated wound fluid, demonstrating suitability for topical wound treatment. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33802607/))
- Topical treatment with Pinus brutia bark extract cream significantly accelerated incision wound healing in albino rats, demonstrating a 35% decrease in MDA and a 46.8% increase in SOD activity compared to the control group. ([Die Pharmazie, 2013](https://pubmed.ncbi.nlm.nih.gov/23444785/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this ampoule is highly recommended for those with sensitive, oily, and acne-prone skin due to its fast-absorbing, watery texture that effectively calms redness and inflammation without causing breakouts. Users appreciate its gentle formulation and ability to refine skin texture. However, individuals with dry skin may find it insufficient on its own and need to layer with a richer moisturizer.

- Liked: Soothing and calming (mostly mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Non-irritating formula (often mentioned)
- Liked: Gentle texture improvement (sometimes noted)
- Disliked: Insufficient for dry skin (sometimes noted)
- Disliked: Small volume/price (sometimes noted)
- Disliked: Breakouts/reactions (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ROUND LAB Pine Calming Cica Ampoule a great fit for skin with dark spots?

This ampoule is a great fit because it contains capryloyl salicylic acid for mild exfoliation to address dark spots, alongside ingredients that calm and keep your skin soft. These soothing and gentle exfoliating benefits help improve uneven tone while keeping your skin calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146601/)

### Which ingredients make this ampoule a good fit for skin with dark spots?

Capryloyl Salicylic Acid helps moderately address pigmentation through mild exfoliation, while Pine Extract, Centella Asiatica Extract, Sodium Hyaluronate, Glycerin, and Madecassoside support overall skin health and calm the area. This ingredient combination is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146601/)

### What does Pine Extract do for skin with dark spots?

Pine extract helps fade dark spots and uneven skin tone by reducing pigment production in the skin. This ingredient is unlikely to irritate dry or oily skin types and supports a clearer, more even complexion.
Sources: [Skin Pharmacology and Physiology, 2016](https://pubmed.ncbi.nlm.nih.gov/26492562/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/33960120/)

### What does Centella Asiatica Extract do for skin with dark spots?

Centella Asiatica Extract helps fade dark spots by slowing down the process that creates excess pigment in the skin. It also provides strong antioxidant and calming benefits that support a smooth, even tone.
Sources: [Molecular Medicine Reports, 2014](https://pubmed.ncbi.nlm.nih.gov/24756377/), [International Journal of Molecular Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39513603/)

### Where does this ampoule go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Using it at this step helps calm the skin and gently address dark spots without harsh irritation.

### Can I use this ampoule with retinol, and in what order?

Yes, you can use this ampoule with retinol, applying the treatment before your moisturizer. It is unlikely to cause irritation because the formula lacks harsh ingredients, and ingredients like sodium hyaluronate and madecassoside help keep skin calm and hydrated while you use retinol.
Sources: [Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/)

### How often should I use this ampoule?

This treatment fits your skin with dark spots very well and is used in the evening routine. It has a very safe profile with no harsh ingredients, making it unlikely to cause irritation on normal skin.

### Can this ampoule clog pores, cause breakouts or purging for skin with dark spots?

This ampoule is unlikely to clog pores or cause breakouts for skin with dark spots because it has an excellent safety profile with no harsh ingredients. Reviewers rarely report breakouts or reactions, and it uses gentle exfoliating ingredients that help smooth the skin without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146601/)

### Is this ampoule fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/es/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €122.90 at Amazon
- [SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dark-spots) — High fit — €8.49 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/es/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €11.30 at Amazon
- Moisturizer: [Torriden DIVE-IN Low Molecule Hyaluronic Acid Multi Pad](https://lovi.care/skincare/es/p/torriden/dive-in-low-molecule-hyaluronic-acid-multi-pad/for/dark-spots) — Superior fit — €17.90 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Butylene Glycol, Dipropylene Glycol, Glycereth-26, Glycerin, 2-Hexanediol, Propanediol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Ethylhexyl Glycerin, Water, Glycoprotein, Indo Mulberry Leaf Extract, Yellow Lotus Root Extract, Indo Mulberry Flower Extract, Hydroxyacetophenone, Asiaticoside, Asiatic Acid, Madecassoside, Madecasic Acid, Sodium Citrate, Capryloyl Salicylic Acid, Disodium Edta, Xanthan Gum, Carbomer, Tromethamine, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- France: https://lovi.care/skincare/fr/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/dark-spots (this page)
- Canada: https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/round-lab/pine-calming-cica-ampoule/for/dark-spots