# REJURAN Turnover Active Cream for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [REJURAN](https://lovi.care/skincare/es/brands/rejuran)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and general skincare benefits for your normal skin, as glycerin and hyaluronic acid provide essential hydration and plumpness.
- While supportive for overall skin health, these ingredients are not specialized to target your primary concerns of wrinkles and fine lines.
- The formulation is safe for your normal skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Hyaluronic Acid, Chlorella Vulgaris Extract, Adenosine, Panthenol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Lipid extracts of Chlorella vulgaris and Arthrospira platensis protect Normal Human Dermal Fibroblasts against UVA-induced oxidative stress and 2-propanol-induced IL-6 expression in vitro. ([Food Science and Technology International = Ciencia Y Tecnologia de Los Alimentos Internacional, 2026](https://pubmed.ncbi.nlm.nih.gov/39033441/))
- Oral and topical administration of ROQUETTE Chlorella sp. at higher doses significantly reduced skin inflammation scores and improved the healing process and duration of skin wounds in mice compared to untreated models. ([Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, 2014](https://pubmed.ncbi.nlm.nih.gov/24965517/))
- Resilient factor (RF, an aqueous extract fraction of Chlorella) suppressed PMA- and UVB-induced MMP1 production, protein, and gene expression, prevented UVB-suppressed elastin protein, and increased pro-collagen mRNA expression in human skin fibroblasts compared to untreated controls. ([European Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18474460/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))

## Why other moisturizers fit mature skin better

- Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss. ([Acta Biochimica Polonica, 2012](https://pubmed.ncbi.nlm.nih.gov/22428137/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- A supramolecular system of malic acid-derived ionic liquid and acetyl hexapeptide-8 enhanced transdermal permeation by 3.10 times, increased collagen production, inhibited acetylcholine release, and reduced wrinkle number, length, and area compared to peptide monotherapy in human subjects. ([Journal of Materials Chemistry. B, 2025](https://pubmed.ncbi.nlm.nih.gov/40626902/))

## What reviewers say

This cream is highly praised for its regenerative properties, with users frequently reporting improved skin texture, elasticity, and a healthy glow. It is also noted for its lightweight, non-greasy feel and quick absorption. However, some users with very dry skin find it insufficient as a standalone moisturizer, requiring additional hydration. The price and small size are common complaints, and a few users experienced packaging difficulties or occasional breakouts.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Regenerates skin (often mentioned)
- Disliked: Expensive for size (often mentioned)
- Liked: Anti-aging effects (sometimes noted)
- Liked: Good for sensitive skin (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Difficult packaging (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does REJURAN Turnover Active Cream work for mature skin?

REJURAN Turnover Active Cream works moderately well for mature skin because glycerin and hyaluronic acid provide essential hydration and plumpness, though it lacks specialized ingredients to target wrinkles and fine lines. To better support mature skin, a product of this type needs specialized anti-aging ingredients, peptides, and antioxidant protection to effectively address wrinkles and fine lines while keeping skin healthy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this cream a good fit for mature skin?

This cream works for mature skin because glycerin and hyaluronic acid provide essential hydration and plumpness. However, a product for this skin needs specialized ingredients like peptides and snail mucin to effectively address wrinkles and fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes in the evening routine after your cleansing toner and before your moisturizer. It offers moderate hydration, but mature skin also needs specialized ingredients like firming peptides and antioxidants to properly target wrinkles and fine lines.

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol, and applying it after your retinol treatment helps keep your skin soft and calm. This product type needs ingredients like peptides, antioxidants, or retinoids to properly target fine lines and wrinkles on mature skin.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

Use this cream twice a day as a daily moisturizer to keep your skin hydrated and smooth. Regular daily use helps maintain skin moisture and supports overall skin barrier health.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause breakouts for mature skin, as it has a safe formulation with no harsh or prohibited ingredients. Reviewers rarely report breakouts from using it.

### Can I use this cream around the eyes or on my body?

This cream is safe to use around the eyes or on the body, as its gentle ingredients are unlikely to cause irritation. Because the skin around the eyes is exceptionally thin, products used there generally benefit from specialized smoothing and firming ingredients that target fine lines.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin) — Superior fit — €19.75 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/es/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/mature-skin) — Superior fit — €92.00 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/es/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/mature-skin) — High fit — €60.90 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Bioré UV Perfect Milk SPF 50+ PA++++](https://lovi.care/skincare/es/p/biore/uv-face-milk-spf50-pa/for/mature-skin) — Superior fit — €25.88 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Butylene Glycol, Methyl Hydrogenated Rosinate, Dipropylene Glycol, Distarch Phosphate, Dicaprylyl Carbonate, Cetearyl Alcohol, Niacinamide, Pentylene Glycol, Polyglyceryl-3 Methylglucose Distearate, 1,2-Hexanediol, Chlorella Vulgaris Extract, Vincetoxicum Atratum Extract, Caesalpinia Spinosa Fruit Extract, Althaea Rosea Flower Extract, Kappaphycus Alvarezii Extract, Prunus Amygdalus Dulcis Seed Extract, Hyaluronic Acid, Bis-Diglyceryl Polyacyladipate-2, Octyldodecanol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Tromethamine, Fructooligosaccharides, Fructose, Panthenol, Cetearyl Glucoside, Adenosine, Sodium Phytate, Tocopherol, Ethylhexylglycerin, Trehalose, Urea, Glyceryl Polyacrylate, Serine, Caprylyl Glycol, Algin, Pullulan, Disodium Phosphate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/rejuran/turnover-active-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/rejuran/turnover-active-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/rejuran/turnover-active-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/rejuran/turnover-active-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/rejuran/turnover-active-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/rejuran/turnover-active-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/rejuran/turnover-active-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/rejuran/turnover-active-cream/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/rejuran/turnover-active-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/rejuran/turnover-active-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/rejuran/turnover-active-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/rejuran/turnover-active-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/rejuran/turnover-active-cream/for/mature-skin