REJURAN DUAL EFFECT AMPOULE for mature skin
Blackberry Leaf Extract
Glycyrrhiza Glabra Extract Licorice Extract
Calendula Officinalis Flower ExtractAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for mature skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your normal skin, as hyaluronic acid and niacinamide provide excellent hydration and smoothing, though they do not specifically target your primary concern of wrinkles and fine lines.
- Ingredients like aloe barbadensis leaf juice and adenosine offer general skincare support, but a more targeted approach for wrinkle reduction would be ideal.
- The product is safe for your normal skin, with no reported risks of irritation due to the absence of harsh or prohibited ingredients.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.8Overall rating based on 500+ reviewsThis ampoule is widely praised for delivering the "glass skin" look, with users reporting immediate improvements in hydration, radiance, and skin texture. It is particularly favored by those with aging or damaged skin for its ability to smooth fine lines and repair the skin barrier using its signature salmon DNA (PDRN) formula, though its high price point is a common contention.
Highlights
Instant Glow Mostly Mentioned
- “gave me an instant inner glow”
- “skin looks luminous and healthy”
- “woke up with a glass-like shine”
High price point Mostly Mentioned
- “way too expensive for 30ml”
- “waiting for a sale to repurchase”
- “pricey for daily use”
Deep Hydration Often Mentioned
- “skin feels plump and hydrated”
- “relieved my inner dryness”
- “bouncy and soft texture”
Texture Smoothing Often Mentioned
- “smoothed out my rough patches”
- “skin feels like silk”
- “makeup applies much better now”
Packaging issues Often Mentioned
- “dropper is annoying to use”
- “hard to get the last bit out”
- “syringe mechanism gets stuck”
Fast Absorption Sometimes Noted
- “absorbs instantly”
- “not sticky at all”
- “layers well under makeup”
Soothing & Repair Sometimes Noted
- “calmed my redness overnight”
- “healed my damaged barrier”
- “soothing after microneedling”
Breakouts/Irritation Rarely Noted
- “gave me small whiteheads”
- “caused a rash on my cheeks”
- “skin felt itchy after use”
Heavy/Sticky finish Rarely Noted
- “felt a bit heavy in summer”
- “left a sticky film”
- “too rich for oily skin”
Not hydrating enough Rarely Noted
- “needed a heavy cream on top”
- “felt dry by midday”
- “not enough for winter”
Sources: lovi.care, oliveyoung.com, shopee.ph, skinsort.com, reddit.com, lmching.com, and more
Questions and answers
How well does Rejuran Dual Effect Ampoule work for mature skin?
REJURAN DUAL EFFECT AMPOULE offers moderate benefits for mature skin as hyaluronic acid and niacinamide provide good hydration and smoothing, though they do not specifically target fine lines and wrinkles. A product for this skin needs dedicated anti-wrinkle ingredients and targeted firming agents to effectively smooth out lines and boost vitality.
International Journal of Molecular Sciences, 2026International Journal of Cosmetic Science, 2018
Which ingredients make this serum a good fit for mature skin?
Hyaluronic acid and niacinamide make this serum a good fit for mature skin by providing hydration and smoothing. To better target wrinkles and fine lines, a product for this skin needs effective anti-wrinkle and hydrating ingredients that enhance vitality and radiance.
What does Blackberry Leaf Extract do for mature skin?
Blackberry Leaf Extract helps keep mature skin firm and smooth by protecting the natural elements that give skin its bounce. It also helps calm redness and keeps skin looking fresh as it ages.
What does Licorice Extract do for mature skin?
Licorice extract helps improve mature skin by fighting cell damage from daily stress, supporting collagen and barrier proteins, and brightening dark spots. It is unlikely to cause irritation and may help smooth and firm dry or aging skin.
Journal of Medicinal Food, 2020Current Pharmaceutical Design, 2019
Where does this serum go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and before moisturizing, following the simple steps for this skin type. Mature skin needs products with powerful peptides, retinoids, or targeted antioxidants to effectively smooth out wrinkles and fine lines.
Can I use this serum with retinol, and in what order?
You can use this treatment in your evening routine before your moisturizer, and applying it with a barrier-enhancing moisturizer helps your skin adjust to retinol. This product is safe for your skin with no reported risks of irritation, but mature skin needs targeted ingredients like peptides or concentrated retinoids to effectively reduce wrinkles and fine lines.
How often should I use this serum?
You can use this treatment in your evening routine for simplicity and extra safety around sun exposure, though some treatments can also be used in the morning or twice a day. It is safe for your skin with no reported risks of irritation, and daily application helps improve moisture and smoothness.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this serum clog pores, cause breakouts or purging for mature skin?
This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a low risk of irritation and reviewers rarely report breakouts. To better target fine lines and wrinkles, mature skin needs ingredients like concentrated peptides or retinol along with rich moisturizers.
Can I use this serum around the eyes or on my body?
You can use this moisturizing treatment on your body and around your eyes, as it is safe for normal skin with no harsh ingredients. However, because mature skin needs products with targeted wrinkle-smoothing ingredients and rich moisturizers to truly soften lines and firm thin areas, this formula only offers moderate benefits.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.
International Journal of Cosmetic Science, 2018Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.
Journal of Cosmetic Dermatology, 2019A blackberry and dill extract combination synergistically increased skin elasticity and induced elastogenesis compared to each ingredient alone and placebo.
International Journal of Cosmetic Science, 2020Tropical highland blackberry juice reduced UVB-mediated DNA damage and increased apoptosis in human epidermal keratinocytes and a reconstituted skin equivalent model.
Photochemistry and Photobiology, 2013Strawberry and blackberry crude extracts, anthocyanin-enriched fractions, and proanthocyanidin-enriched fractions demonstrated anti-inflammatory effects through ROS reduction, gene expression inhibition, and NO suppression, while anthocyanin fractions promoted fibroblast migration in vitro.
Food Research International, 2019Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.
Evidence-based Complementary and Alternative Medicine, 2015Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.
Experimental Dermatology, 2015Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.
Advanced Science, 2025Topical application of Calendula officinalis extract cream significantly improved skin hydration and firmness (reflected in significant changes in R0 and R6 parameters) in 21 healthy human volunteers compared to a base cream.
Acta Poloniae Pharmaceutica, 2011Treatment with standardized extract of Calendula officinalis L. led to a shorter epithelization time and faster healing speed compared to mineral oil in patients with acute skin loss wounds of the hand and fingers healing by secondary intention.
Tissue Barriers, 2022Topical administration of Calendula provides weak evidence of effectiveness in acute and chronic wounds compared to standard treatments based on a narrative review of available trials.
Wounds, 2008
Ingredients
Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Blueberry Fruit Extract, Morus Nigra Fruit Extract, Peg-6, Glycerin, Water, Hyaluronic Acid, Niacinamide, Dipropylene Glycol, Butylene Glycol, 1,2-Hexanediol, Carbomer, Gerotine Hydrolyzed Dna, Hydrolyzed Dna, Xanthan Gum, Polysorbate 20, Adenosine, Tocopheryl Acetate, Bisabolol, Arbutin, Ethylhexylglycerin, Caprylyl Glycol, Hexylene Glycol, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide Np, Oleic Acid, Inulin Lauryl Carbamate, Cholesterol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.