# Perricone MD Rebalancing Elixir for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Perricone MD](https://lovi.care/skincare/es/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this product effectively mattifies and controls oil production with capryloyl glycine and sodium bicarbonate, while the anti-inflammatory and sebum-regulating properties of Cannabidiol and Annona Cherimola Fruit Extract offer moderate benefits for your acne, blemishes, and breakouts.
- Ganoderma Lucidum Stem Extract and Grifola Frondosa Fruiting Body Extract further support skin balance and hydration, contributing to overall skin health.
- The formula is safe for your acne-prone skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/oily-acne-prone-skin): High

## Key ingredients

Cannabidiol, Mushroom Complex, Cherimoya Fruit Extract, Capryloyl Glycine, Sodium Pca

## What the research says

- Topical application of an anti-aging gel containing EPA and CBD reduced inflammatory agents, decreased crow's feet and fine line wrinkle volume, reduced the subepidermal low-echogenic band by 8.8%, and increased skin hydration by 31.2% and elasticity by 25.6% in 33 participants over 56 days compared to baseline. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/))
- Topical nano-cannabidiol cream reduced UV-A-induced epidermal hyperplasia, nuclear DNA base lesions, and mitochondrial DNA deletions compared with vehicle in nineteen participants. ([Journal of the American Academy of Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39025264/))
- The addition of Reishi, Maitake, and Lion's Mane extracts to washing gels reduced skin irritation and intracellular free radical production, positively affected skin pH and hydration, and decreased transepidermal water loss compared with a cosmetic base. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36014338/))
- Daily application of a novel retinol and cannabidiol combination topical improved global skin quality across 13 domains, including visible pores, dehydration, surface roughness, and static and dynamic wrinkles, in 10 patients with facial skin imperfections. ([Aesthetic Surgery Journal. Open Forum, 2022](https://pubmed.ncbi.nlm.nih.gov/35274096/))
- Topical application of carboxymethylcellulose/chitosan hydrogel loaded with cannabidiol reduced inflammation and increased collagen production in radiation-combined wound skin injury in mice. ([Phytomedicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40318533/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of a formulation containing capryloyl glycine 4% significantly decreased hair density, median hair length, and terminal hair density on the forearms compared to placebo in female patients with hypertrichosis after 120 days. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33347705/))
- A novel natural carrier-free assembled gel composed of sodium pyrrolidone carboxylate and baicalin alleviates UVB-induced skin photodamage by scavenging reactive oxygen species, protecting mitochondria, restoring oxidative homeostasis, inhibiting inflammatory responses, and regulating collagen-related proteins. ([Biomaterials Advances, 2026](https://pubmed.ncbi.nlm.nih.gov/41129958/))

## What reviewers say

Most users find it provides lightweight hydration that absorbs quickly without feeling heavy, leading to improved skin balance and texture. A moderate number of users feel the product is too expensive for the results, and a low number dislike the natural scent or do not see dramatic anti-aging effects.

- Liked: Soothes sensitive skin (mostly mentioned)
- Liked: Lightweight hydration (often mentioned)
- Liked: Good for layering (sometimes noted)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Expensive for results (sometimes noted)
- Disliked: Not a miracle worker (rarely noted)
- Disliked: Product availability issues (rarely noted)
- Disliked: Unpleasant natural scent (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Perricone MD Rebalancing Elixir a great fit for acne-prone skin?

Perricone MD Rebalancing Elixir is a great fit for acne-prone skin because it controls oil and mattifies the skin with capryloyl glycine and sodium bicarbonate, while Cannabidiol and Cherimoya Fruit Extract calm breakouts. A mushroom complex further helps balance and hydrate the skin safely without irritation.
Sources: [Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36014338/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/)

### Which ingredients make this elixir a good fit for acne-prone skin?

Cannabidiol, cherimoya fruit extract, capryloyl glycine, and sodium bicarbonate make this elixir a great fit by helping control oil and calm breakouts on acne-prone skin. The mushroom complex further supports skin balance and hydration, and the formula is unlikely to cause irritation.
Sources: [Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36014338/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/)

### What does Cannabidiol do for acne-prone skin?

Cannabidiol helps calm acne-prone skin by reducing inflammation and balancing oil production. It is unlikely to cause irritation and may help soothe redness and breakouts.
Sources: [The Journal of Clinical Investigation, 2014](https://pubmed.ncbi.nlm.nih.gov/25061872/), [Experimental Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27094344/)

### What does Mushroom Complex do for acne-prone skin?

Mushroom Complex helps calm oily and breakout-prone skin by soothing redness and irritation. It also provides antioxidant support to protect the skin from everyday stress, though a product for this skin type typically needs added blemish-clearing ingredients like salicylic acid or niacinamide to fully clear pores.
Sources: [Archives of Dermatological Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40057933/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24002162/)

### Where does this elixir go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Some treatments can also be used in the morning or twice a day.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first and following with this product, or by using them on alternate nights to keep your skin calm and clear. This approach helps manage breakouts while keeping your skin balanced and hydrated without irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this elixir?

This treatment is applied in the evening as part of your routine. It helps control oil and calm breakouts while keeping your skin balanced and hydrated.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to clog pores, cause breakouts, or lead to purging on acne-prone skin. It is very safe for this skin type and helps control oil production while calming blemishes without any harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/), [Journal of the American Academy of Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39025264/)

### Is this elixir fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — €8.49 at Amazon
- [Purito Galacto Niacin 97 Power Essence](https://lovi.care/skincare/es/p/purito/galacto-niacin-97-power-essence/for/acne-prone-skin) — High fit — €18.95 at Amazon
- [Dr. Ceuracle Tea Tree Purifine 95 Essence](https://lovi.care/skincare/es/p/dr-ceuracle/tea-tree-purifine-95-essence/for/acne-prone-skin) — High fit — €21.90 at Notino

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €17.49 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, 1,2-Hexanediol, Sodium Pca, Triethyl Citrate, Propanediol, Capryloyl Glycine, Glycerin, Annona Cherimola Fruit Extract, Cannabidiol, Ganoderma Lucidum Stem Extract Mushroom Stem Extract, Grifola Frondosa Fruiting Body Extract, Sodium Bicarbonate, Caprylhydroxamic Acid, Sodium Hydroxide, Citric Acid, Cannabis Sativa Glycereth-8 Esters Seed Oil, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sodium Citrate, Lentinus Edodes Mycelium Extract, Sodium Dehydroacetate, Phenylpropanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/rebalancing-elixir/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/rebalancing-elixir/for/acne-prone-skin