# Perricone MD High Potency Retinol Recovery Overnight Moisturizer for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Perricone MD](https://lovi.care/skincare/es/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- This moisturizer offers moderate hydration and texture smoothing for your normal skin due to the presence of retinol and sodium hyaluronate, which promote cell turnover and plumpness.
- While beneficial for general anti-aging, the retinol and retinyl linoleate concentrations are not specifically targeted to address your redness and irritation concerns.
- The product is safe for your sensitive skin, as it lacks harsh ingredients and has a low risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Dmae, Sodium Hyaluronate, Squalane, Ceramide Np

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo. ([American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/))
- A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE. ([Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/))
- A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties. ([Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## Why other moisturizers fit sensitive skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A dexpanthenol-containing cream accelerated skin barrier repair, increased stratum corneum hydration, reduced skin roughness, and decreased skin redness compared to vehicle and untreated controls in sodium lauryl sulphate-irritated skin. ([The Journal of Dermatological Treatment, 2002](https://pubmed.ncbi.nlm.nih.gov/19753737/))

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Retinol Recovery Overnight Moisturizer work for sensitive skin?

This moisturizer is an average fit for sensitive skin because its retinol helps smooth texture, but it lacks specific ingredients to calm redness and irritation. To truly comfort sensitive skin, a product of this type needs soothing ingredients like fermented Centella Asiatica, cica ceramide, and nourishing oils that strengthen the skin barrier.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this cream a good fit for sensitive skin?

This cream is safe for sensitive skin as it lacks harsh ingredients and has a low risk of irritation, though other products fit this skin type better. A product of this type needs soothing ingredients that specifically target redness and irritation, along with nourishing oils and ceramides to strengthen the skin barrier without overwhelming it.

### What does Retinol do for sensitive skin?

Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### What does DMAE do for sensitive skin?

DMAE may not be the best fit for sensitive skin, because active firming ingredients of this type can sometimes cause irritation and swelling. Sensitive skin needs gentle, soothing ingredients like calming plant extracts and hydrating ceramides to stay soft and smooth without redness.
Sources: [The British Journal of Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17300230/)

### Where does this cream go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after cleansing and toning, followed by a moisturizer. It is unlikely to cause irritation on sensitive skin, though a product of this type for this skin needs soothing ingredients and calming agents to target redness.

### Can I use this cream with vitamin C, and in what order?

You can use this cream with vitamin C by applying vitamin C in the morning and this treatment at night. Because this product contains retinol, separating them helps avoid extra redness and irritation on sensitive skin.

### How often should I use this cream?

This cream is designed for evening use as a treatment step in your routine, helping smooth texture while being safe for sensitive skin. A product of this type for sensitive skin needs soothing agents and gentle hydrating ingredients to calm redness while keeping skin soft.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to clog pores or cause breakouts on sensitive skin, though the retinol may cause mild purging as it speeds up cell turnover. A sensitive skin product needs gentle ingredients like ceramides and squalane to keep the skin barrier calm and comfortable.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Can I use this cream around the eyes or on my body?

This cream is safe for the skin, but because the eyelid is one of the thinnest areas on the body, potent active ingredients like retinol may require careful testing to avoid irritation. A product intended for this skin needs gentle hydrating agents and soothing barrier-supportive ingredients without strong anti-aging actives.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, geraniol, and eugenol). Cetearyl alcohol and behenyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for sensitive skin

- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/es/p/belif/the-true-cream-aqua-bomb/for/sensitive-skin) — High fit — €35.00 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/sensitive-skin) — High fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/sensitive-skin) — High fit — €11.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.80 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/es/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.13 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Caprylic Capric Triglyceride, C12-15 Alkyl Benzoate, Propanediol, Shea Ethyl Esters Butter, Dicaprylyl Carbonate, Cetearyl Alcohol, Dimethicone, Squalane, Behenyl Alcohol, Hydrogenated Glycerides, Isoamyl Laurate, Aleurites Moluccana Seed Oil, Glyceryl Stearate, Peg-100 Stearate, Hydrogenated Oil, Hydrogenated Soybean Oil, Ceteareth-20, Glycerin, Phenoxyethanol, Polysilicone-11, Sodium Stearoyl Glutamate, Hydrogenated Olive Oil, Citric Acid, Dimethyl Mea, Petrolatum, Hydrogenated Jojoba Oil, Ethylhexylglycerin, Retinol, Retinyl Linoleate, Xanthan Gum, Polysorbate 20, Parfum, Tetrasodium Glutamate Diacetate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Glycine Soja Soybean Lipids, Maltodextrin, Pentylene Glycol, Cetyl Palmitate, Laureth-23, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Nephelium Lappaceum Leaf Extract, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Ceramide Np, Sodium Hydroxide, Trideceth-6 Phosphate, Magnesium Aspartate, Zinc Gluconate, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Magnesium Sulfate, Sodium Hyaluronate Crosspolymer, Phytosterols, Tocopherol, Copper Gluconate, Citronellol, Geraniol, Hydroxycitronellal, Eugenol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/high-potency-retinol-recovery-overnight-moisturizer/for/sensitive-skin