# Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Perricone MD](https://lovi.care/skincare/es/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing benefits for your normal skin, as Glycerin and Palmitoyl Glycine hydrate and smooth texture, but these ingredients do not directly address your primary concerns of redness and irritation.
- While S-Palmitathione and Tetrahexyldecyl Ascorbate provide antioxidant support beneficial for normal skin, they offer limited impact on inflammation.
- The product is safe for your sensitive skin, containing no harsh or prohibited ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Tetrahexyldecyl Ascorbate, Lactic Acid, Macadamia Ternifolia Seed Oil, Vitamin F Blend

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9692305/))
- Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face. ([The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29344315/))
- Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin. ([Biological & Pharmaceutical Bulletin, 2004](https://pubmed.ncbi.nlm.nih.gov/15056874/))

## Why other moisturizers fit sensitive skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A dexpanthenol-containing cream accelerated skin barrier repair, increased stratum corneum hydration, reduced skin roughness, and decreased skin redness compared to vehicle and untreated controls in sodium lauryl sulphate-irritated skin. ([The Journal of Dermatological Treatment, 2002](https://pubmed.ncbi.nlm.nih.gov/19753737/))

## What reviewers say

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Pleasant texture (often mentioned)
- Disliked: Expensive price (often mentioned)
- Liked: Improves radiance (sometimes noted)
- Disliked: Limited wrinkle results (sometimes noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer work for sensitive skin?

This moisturizer works reasonably well for sensitive skin, hydrating and smoothing texture safely without causing irritation, though it does little to directly calm redness. Sensitive skin typically needs soothing ingredients like fermented Centella Asiatica, cica ceramide, and nourishing oils to strengthen the skin barrier and target redness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for sensitive skin?

Glycerin helps hydrate and smooth your skin safely, but a moisturizing treatment for sensitive skin needs soothing ingredients like fermented Centella Asiatica, cica ceramide, and nourishing oils to calm redness and irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Acyl-Glutathione do for sensitive skin?

Acyl-glutathione helps protect sensitive skin by reducing oxidative stress and fighting environmental damage, though a product for this skin type also needs soothing ingredients to calm irritation and strengthen the skin barrier.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41502039/)

### What does Vitamin C do for sensitive skin?

For sensitive skin, Vitamin C helps calm redness and evens out dark spots while improving overall skin quality and radiance. Daily use is generally well-tolerated and may help protect against environmental stress.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38525606/)

### Where does this cream go in a skincare routine for sensitive skin?

This moisturizing treatment goes in the evening routine after a cleanser and soothing toner, followed by a moisturizer. Sensitive skin needing a better fit requires products with soothing botanical extracts and gentle anti-inflammatory ingredients to calm redness and irritation.

### Can I use this cream with retinol, and in what order?

You can use this treatment after your retinol at night, provided your sensitive skin tolerates the lactic acid and other active ingredients well. Because this product does not directly target redness, sensitive skin needs a moisturizer or treatment packed with soothing plant extracts and barrier-strengthening ceramides to keep skin calm and smooth.

### How often should I use this cream?

This cream works well for daily use to hydrate and smooth your skin, though it offers an average fit since it does not directly target redness. To properly care for sensitive skin, a product of this type needs soothing and anti-inflammatory ingredients that calm irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to clog pores or cause breakouts for sensitive skin because it is free of harsh ingredients that typically cause irritation. However, because it provides only moderate moisture without directly calming redness, sensitive skin prone to breakouts often benefits more from gentle, fragrance-free hydrators paired with soothing plant extracts like centella asiatica.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream around the eyes or on my body?

This cream is generally safe to use on delicate areas like the face, but because it is an average fit for sensitive skin, it needs soothing plant oils and gentle hydrators to properly comfort and protect thin skin without causing irritation.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/es/p/belif/the-true-cream-aqua-bomb/for/sensitive-skin) — High fit — €35.00 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/sensitive-skin) — High fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/sensitive-skin) — High fit — €11.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.80 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/es/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.13 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin
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- Spain: https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin
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