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Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

Average

  • HighCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for acne-prone skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate moisturizing benefits for your combination skin, with glycerin and S-palmitoylglutathione providing hydration and plumping effects, though it does not specifically target your acne concerns.
  • Palmitoyl glycine and macadamia ternifolia seed oil offer antioxidant support and nourishment, which are generally beneficial but not directly aimed at reducing blemishes.
  • The product is safe for your combination skin, as it lacks harsh ingredients and poses no irritation risk.

How to apply

  • Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
  • Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
  • Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
  • Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
  • Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.

People Say

★4.5Overall rating based on 500+ reviews

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “Keeps skin hydrated all day.”
    • “Great for dry patches.”
    • “Feels very moisturizing.”
  • Fast absorbing Often Mentioned
    • “Absorbs fast, not greasy.”
    • “No residue feel afterwards.”
    • “Absorbs quickly without stickiness.”
  • Pleasant texture Often Mentioned
    • “Light, velvety texture.”
    • “Not too heavy, not too light.”
    • “Creamy, not greasy.”
  • Expensive price Often Mentioned
    • “On the steep side.”
    • “More expensive side.”
    • “Price is quite high.”
  • Improves radiance Sometimes Noted
    • “Produces a radiant glow.”
    • “Skin looks healthier.”
    • “Imparts a beautiful radiance.”
  • Limited wrinkle results Sometimes Noted
    • “Haven't noticed much difference.”
    • “Not as good as advertised.”
    • “Deep lines remain.”
  • Strong fragrance Rarely Noted
    • “Fragrance too strong.”
    • “Concerned about fragrance.”
    • “Experienced minor irritation.”

Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more

Questions and answers

How well does Essential Fx Acyl-Glutathione Rejuvenating Moisturizer work for acne-prone skin?

This moisturizer works reasonably well for acne-prone skin, providing moderate hydration and antioxidant support, though it does not specifically target blemishes. A product of this type for acne-prone skin needs ingredients that actively help clear blemishes and breakouts, soothe irritation, and balance moisture without clogging pores.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for acne-prone skin?

This cream works for acne-prone skin because glycerin and S-palmitoylglutathione provide hydration, while palmitoyl glycine and macadamia seed oil offer nourishment and antioxidant support. However, a product for this skin needs ingredients that directly target blemishes and breakouts while providing safe hydration and soothing benefits without irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Acyl-Glutathione do for acne-prone skin?

Acyl-Glutathione helps support antioxidant defense and calm skin, but acne-prone skin typically needs ingredients that clear pores and reduce breakouts.

The Journal of Clinical and Aesthetic Dermatology, 2025

What does Vitamin C do for acne-prone skin?

Vitamin C helps brighten dark spots left behind by breakouts and calms redness in acne-prone skin. Daily use may also help improve overall skin clarity and support an even skin tone.

Journal of Cosmetic Dermatology, 2024Journal of Cosmetic Dermatology, 2019

Where does this cream go in a skincare routine for acne-prone skin?

This moisturizing treatment goes after your hydrating toner in the morning and after your treatment step in the evening. It provides moderate hydration and nourishment, but acne-prone skin works best with a product of this type that also targets blemishes.

Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol, applying it after your retinol treatment to help soothe the skin and lock in moisture. Acne-prone skin works best with a moisturizer that offers blemish-fighting and pore-clearing ingredients like salicylic acid or niacinamide.

How often should I use this cream?

This moisturizing treatment works well for daily hydration, but because it is an average fit for acne-prone skin, it lacks specific ingredients to target blemishes. To properly care for acne-prone skin, a product of this type needs blemish-clearing ingredients like salicylic acid or benzoyl peroxide to help keep pores clear.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to cause irritation on your acne-prone skin since it lacks harsh ingredients, but it does not target blemishes either. Acne-prone skin works best with products that contain soothing and clearing ingredients to help keep pores clear.

Can I use this cream around the eyes or on my body?

This cream is safe to use around the eyes or on the body, as it poses no irritation risk. However, acne-prone skin generally needs products with targeted blemish-fighting ingredients and lightweight hydration to properly care for delicate or body areas without clogging pores.

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Why other moisturizers fit acne-prone skin better

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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