# Perricone MD Deep Crease Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Perricone MD](https://lovi.care/skincare/es/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- This product offers moderate benefits for your normal skin, with S-Palmitoylglutathione and Tetrahexyldecyl Ascorbate providing antioxidant activity and supporting collagen synthesis to address fine lines and wrinkles.
- Glycerin and Squalane offer general hydration and soothing effects that can support your redness and irritation, though they are not specifically targeted for these concerns.
- The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8

## What the research says

- A 3-in-1 anti-aging topical night serum-in-oil applied once daily decreased wrinkles by 11%, increased skin firmness by 8%, reduced redness by 70%, and improved overall skin quality and complexion in 103 female subjects over 28 to 84 days compared to baseline. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate. ([European Journal of Pharmaceutics and Biopharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28385617/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

Users in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Hydrating formula (often mentioned)
- Liked: Softens deep lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Disliked: Dropper issues (sometimes noted)
- Disliked: Gradual results (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Perricone MD Deep Crease Serum work for sensitive skin?

This product works for sensitive skin, though other products fit it better because they target redness and irritation more effectively. Treatments that fit this skin well need soothing ingredients like niacinamide and snail secretion filtrate to calm redness while supporting skin health.

### Which ingredients make this serum a good fit for sensitive skin?

Glycerin and squalane help provide general hydration and soothing effects that can support sensitive skin, while an absence of harsh ingredients helps maintain a very safe profile. To best fit sensitive skin, treatments of this type need soothing components and ingredients that specifically target redness and irritation.

### What does Acyl-Glutathione do for sensitive skin?

Acyl-glutathione helps protect sensitive skin by reducing oxidative stress and fighting environmental damage, though a product for this skin type also needs soothing ingredients to calm irritation and strengthen the skin barrier.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41502039/)

### What does Palmitoyl Glutathione do for sensitive skin?

Palmitoyl glutathione helps keep sensitive skin calm and smooth by supporting its natural antioxidant defenses and moisture balance. This type of ingredient may improve skin texture and reduce irritation, though results vary depending on the product's overall formula.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Where does it go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your toner and before your moisturizer. It is unlikely to cause irritation for your sensitive skin because it lacks harsh ingredients and contains soothing components, though a product for this skin also needs gentle hydrating and calming ingredients.

### Can I use this serum with retinol, and in what order?

Perricone MD Deep Crease Serum may be used alongside retinol by applying it in your evening routine after cleansing and toning, and before moisturizing. This product is unlikely to irritate sensitive skin because it lacks harsh ingredients and includes soothing components. However, sensitive skin needs a treatment with higher amounts of calming agents and gentle hydrators to manage redness and irritation effectively.

### How often should I use it?

This treatment is used in the evening once a day, and sensitive skin needs a product with gentle antioxidants, hydrating glycerin, and soothing ingredients like squalane to help address fine lines while keeping redness calm.
Sources: [European Journal of Pharmaceutics and Biopharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28385617/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts on sensitive skin, as it has an excellent safety profile and contains no harsh ingredients. To care for sensitive skin best, a treatment product of this type needs calming agents and gentle hydrators like glycerin and squalane to keep the skin comfortable without triggering irritation.

### Is it fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.80 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/es/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.13 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/deep-crease-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/deep-crease-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/deep-crease-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/deep-crease-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/deep-crease-serum/for/sensitive-skin