Perricone MD Deep Crease Serum for combination skin
Acyl-Glutathione- S-Palmitoylglutathione
Tetrahexyldecyl Ascorbate
Palmitoyl Tripeptide-5
Acetyl Hexapeptide-8
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for combination skin; other serums fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- American Journal of Clinical Dermatology, 2013
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for combination skin, as squalane and glycerin provide emollient and humectant actions respectively, but lacks sufficient ingredients for optimal oil control on your oily shine concerns.
- The presence of palmitoyl tripeptide-5 and acetyl hexapeptide-8 offers moderate treatment for minimizing fine lines and wrinkles by plumping and smoothing skin texture.
- The product is safe for your combination skin due to the absence of harsh ingredients and the inclusion of soothing agents like S-Palmitoylglutathione and Rosemary Leaf Extract.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.5Overall rating based on 800+ reviewsUsers in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.
Highlights
Lightweight texture Mostly Mentioned
- “Absorbs quickly”
- “not sticky or greasy”
- “feels silky and smooth”
Hydrating formula Often Mentioned
- “Skin drinks it up”
- “leaves skin feeling plump”
- “adds a boost of moisture”
Softens deep lines Often Mentioned
- “Deeper lines look softer”
- “smile lines appear less pronounced”
- “frown lines look less visible”
High price point Often Mentioned
- “Price is quite premium”
- “barrier for some”
- “expensive investment”
Improves firmness Sometimes Noted
- “Skin feeling firmer”
- “noticeable improvement in bounce”
- “more lifted look”
Dropper issues Sometimes Noted
- “Difficult to pick up product”
- “dropper doesn't work well”
- “inconsistent dispensing”
Gradual results Sometimes Noted
- “Not an overnight miracle”
- “results are subtle”
- “haven't seen 11s improve yet”
Fragrance sensitivity Rarely Noted
- “Rose scent may not be ideal”
- “not for those with fragrance allergies”
Sources: lovi.care, perriconemd.com, dermstore.com, ulta.com, youtube.com, reddit.com, and more
Questions and answers
How well does Perricone MD Deep Crease Serum work for combination skin?
Perricone MD Deep Crease Serum is an average fit for combination skin, as it hydrates dry areas with squalane and glycerin and helps smooth fine lines, but it lacks enough oil-controlling ingredients to manage oily shine. A treatment for this skin needs effective ingredients like niacinamide, propolis, or zinc PCA to regulate oiliness and balance hydration without causing excess oiliness or dryness.
Which ingredients make this serum a good fit for combination skin?
Squalane and glycerin make this serum a moderate fit for combination skin by providing softening and moisture, while peptides help smooth fine lines. However, to truly suit this skin type, a product needs ingredients like niacinamide and zinc PCA to manage oily shine and keep the skin balanced.
What does Acyl-Glutathione do for combination skin?
Acyl-Glutathione helps brighten skin color and smooth out wrinkles while keeping combination skin hydrated. Topical use of glutathione may improve dark spots and reduce water loss, though its overall effect can vary from person to person.
The Journal of Clinical and Aesthetic Dermatology, 2025Journal of Cosmetic Dermatology, 2019
What does Palmitoyl Glutathione do for combination skin?
Palmitoyl Glutathione helps combination skin by improving moisture content, smoothness, and elasticity while supporting a more even skin tone. This ingredient is unlikely to cause irritation and works well to keep skin looking healthy and balanced.
Where does it go in a skincare routine for combination skin?
This treatment goes in the evening routine after cleansing and before moisturizing, though some treatments may also be used in the morning or twice a day. Combination skin needs a product that provides both gentle hydration and strong oil control to manage oily shine properly.
Can I use this serum with retinol, and in what order?
You can use this treatment with retinol, applying the retinol first and waiting for it to absorb before applying this serum. This approach helps minimize potential irritation while delivering the smoothing benefits of both products. To work best for combination skin, this type of product also needs ingredients that help control excess oil and shine.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
How often should I use it?
Use this treatment in the evening as part of your routine. Combination skin needs products that also control oily shine.
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is unlikely to cause breakouts or clog pores on combination skin, as it is free of harsh ingredients and includes soothing agents like S-palmitoylglutathione and rosemary leaf extract. However, because it offers only moderate suitability for your skin, a product of this type needs additional oil-controlling ingredients to properly manage oily shine.
Is it fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.
Colloids and Surfaces. B, Biointerfaces, 2025Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026
Why other serums fit combination skin better
Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024
Ingredients
Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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