# Perricone MD Cold Plasma Plus+ for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Perricone MD](https://lovi.care/skincare/es/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for dry skin as tetrahexyldecyl ascorbate and acetyl hexapeptide-8 work to smooth texture and minimize fine lines, while glycerin and sodium hyaluronate provide essential hydration for dry or flaky skin.
- Helianthus annuus seed oil and echium plantagineum seed oil offer emollient benefits, supporting overall skin comfort for your dry skin type.
- The product is safe for your dry skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid Ester, Copper Tripeptide, Acetyl Hexapeptide-8, Omega 3, Glycolic Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))

## What reviewers say

Based on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.

- Disliked: Unpleasant scent (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: High price tag (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Increases radiance (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Cold Plasma Plus+ work for dry skin?

Perricone MD Cold Plasma Plus+ works moderately well for dry skin, as it smooths texture and brings essential hydration with ingredients like glycerin and sodium hyaluronate. A product of this type needs rich hydrating ingredients, ceramides, niacinamide, and barrier-supporting components to provide optimal nourishment and comfort for dry skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this treatment a good fit for dry skin?

This treatment works for dry skin because tetrahexyldecyl ascorbate and acetyl hexapeptide-8 help smooth texture, while glycerin and sodium hyaluronate provide essential hydration. To fit dry skin even better, products of this type need rich ingredients like ceramides, niacinamide, and barrier-supporting peptides that deliver deep moisture and nourishment.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Ascorbic Acid do for dry skin?

Ascorbic Acid helps dry skin by improving moisture levels and hydration in the outer layer of the skin. It also helps support the skin barrier function to keep moisture locked in.
Sources: [Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/), [Skin Research and Technology, 2008](https://pubmed.ncbi.nlm.nih.gov/19159387/)

### What does Copper Tripeptide do for dry skin?

Copper Tripeptide helps soothe and calm dry skin while improving overall barrier conditions and reducing irritation. This ingredient also works to improve skin smoothness and firmness over time.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### Where does this treatment go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening provides simplicity and extra safety around sun exposure, though some may also be used in the morning or twice a day.

### Can I use this treatment with niacinamide, and in what order?

You can use this treatment with niacinamide by applying niacinamide first and following with this treatment once it absorbs. This combination is generally well tolerated, though dry skin needs a rich moisturizer afterward to lock in hydration and keep the face feeling soft and smooth.

### How often should I use this treatment?

You can use this treatment in the evening as part of your routine for dry skin. To give dry skin the best care, this product type needs rich nourishing oils, soothing plant extracts, and gentle hydrating ingredients.

### Can this treatment clog pores, cause breakouts or purging for dry skin?

This treatment is unlikely to cause breakouts or clog pores on dry skin, and it has a safe profile with a low risk of irritation. A dry skin routine also needs rich moisturizing oils and hydrating ingredients like ceramides and hyaluronic acid to keep skin soft and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/dry-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €8.85 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/dry-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/es/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

- Amazon.de: €145.73 (https://www.amazon.de/dp/B077394HRR?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €28.90 (https://www.notino.es/perricone-md/cold-plasma-plus-hand-therapy-crema-para-cuidar-manos/p-16078159/)
- Lookfantastic: €80.25 (https://www.lookfantastic.es/p/perricone-md-cold-plasma-plus-advanced-eye-cream/13033797/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/dry-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/dry-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/dry-skin