Perricone MD Cold Plasma Plus+ for combination skin
Ascorbic Acid Ester
Copper Tripeptide
Acetyl Hexapeptide-8
Omega 3
Glycolic AcidAverage
- AverageCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for combination skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your combination skin, as tetrahexyldecyl ascorbate and acetyl hexapeptide-8 work to smooth texture and minimize fine lines, though glycerin and sodium hyaluronate provide hydration that is not the primary concern for your oily shine.
- The formula is safe for your combination skin, lacking harsh ingredients that could cause irritation.
- While it offers general skincare benefits, the ingredients are not specifically targeted to address your main goal of managing oily shine.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.2Overall rating based on 1.5k+ reviewsBased on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.
Highlights
Unpleasant scent Mostly Mentioned
- “smells like fish”
- “scent is off-putting”
- “earthy and funky smell”
- “hard to get past the smell”
Improves skin texture Often Mentioned
- “smooths my skin overnight”
- “minimized my large pores”
- “texture is not grainy anymore”
- “skin feels fantastic”
High price tag Often Mentioned
- “very expensive product”
- “not worth the money”
- “price is steep”
- “waiting for a sale”
Fast absorption Sometimes Noted
- “absorbs pretty quickly”
- “sinks right in”
- “lightweight and not sticky”
- “non-greasy finish”
Increases radiance Sometimes Noted
- “saw more radiance”
- “brightening dark spots”
- “skin looks youthful”
- “helps with dullness”
Reduces fine lines Sometimes Noted
- “softens crow's feet”
- “lines appear diminished”
- “helps with wrinkles”
- “skin looks plumper”
Packaging issues Rarely Noted
- “jar is unsanitary”
- “pump stopped working”
- “hard to get product out”
- “prefer a bottle”
Skin irritation Rarely Noted
- “caused redness and burning”
- “broke me out”
- “too strong for sensitive skin”
- “caused dry patches”
Sources: lovi.care, ulta.com, perriconemd.com, amazon.com, sephora.co.uk, lovelyskin.com, and more
Questions and answers
How well does Cold Plasma Plus+ work for combination skin?
Perricone MD Cold Plasma Plus+ offers moderate suitability for your combination skin, smoothing texture and minimizing fine lines, though its hydration is not the primary focus for managing oily shine. A treatment for this skin needs ingredients like niacinamide, propolis, and zinc PCA to regulate oiliness and enhance radiance without irritation.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic Dermatology, 2017
Which ingredients make this treatment a good fit for combination skin?
Tetrahexyldecyl ascorbate and acetyl hexapeptide-8 help smooth texture and minimize fine lines on combination skin. To truly suit this skin type, a product of this type needs ingredients like niacinamide and zinc PCA that regulate oiliness and manage oily shine.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic Dermatology, 2017
What does Ascorbic Acid do for combination skin?
Ascorbic acid helps brighten dark spots and protect combination skin from daily environmental damage. It also provides antioxidant support, which may help keep the skin looking even and healthy.
Clinical, Cosmetic and Investigational Dermatology, 2024Acta Dermato-venereologica, 1996
What does Copper Tripeptide do for combination skin?
Copper Tripeptide helps support firm, smooth skin and is generally gentle enough for combination skin types. It works to boost collagen and repair skin, though a formula meant for this skin type also needs balanced hydration to keep dry patches comfortable and oily areas clear.
International Journal of Molecular Sciences, 2018FEBS Letters, 1988
Where does this treatment go in a skincare routine for combination skin?
This treatment goes in your evening routine, as treatments with active ingredients are usually used at night for simplicity and extra safety around sun exposure. A treatment for your combination skin needs ingredients that help balance oily shine while smoothing texture.
Can I use this treatment with niacinamide, and in what order?
Yes, you can use this treatment with niacinamide by applying niacinamide first and following with this product after it absorbs. A product of this type for combination skin needs lightweight, oil-balancing ingredients that help control shine while keeping the skin smooth and hydrated.
How often should I use this treatment?
This treatment fits into your evening routine once a week to start, as products with exfoliating acids need gradual introduction to keep skin calm. If your skin handles it well, you may carefully use it more often. Combination skin needs ingredients that help balance oil and shine without weighing the skin down.
Can this treatment clog pores, cause breakouts or purging for combination skin?
This treatment is unlikely to clog pores or cause breakouts for your combination skin, as it has a safe formula without harsh ingredients that typically cause irritation. However, because combination skin needs a treatment that specifically targets oily shine, this type of product works best when it also includes ingredients that control excess oil and balance the skin.
Is this treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone.
Dermatologic Surgery, 2017
Why other serums fit combination skin better
Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024
Ingredients
Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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