Origins YOUTHTOPIA™ Peptide Plumping Apple Cream for combination skin

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Questions and answers

What the research says

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.

  Drug Delivery, 2017

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Topical caffeine acts as an active cosmetic compound by preventing excessive fat accumulation through phosphodiesterase inhibition, protecting cells against UV radiation with antioxidant properties, increasing skin microcirculation, and stimulating hair growth via 5-alpha-reductase inhibition.

  Skin Pharmacology and Physiology, 2013

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical formulations containing 1.25% Malus sp. extract or 0.75% rutin protected against UVB-induced sunburn cells, caspase-3 activation, cyclobutane pyrimidine dimers, lipid peroxidation, and metalloproteinase formation in ex vivo skin explants and 3D tissue-engineered skin.

  Rejuvenation Research, 2020

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

Ingredients

Water, Glycerin, Squalane, Caprylic Capric Triglyceride, Isoamyl Laurate, Butyrospermum Parkii Butter Shea Butter, Cetearyl Olivate, Pyrus Malus Seed Oil, Pyrus Malus Extract, Pyrus Malus Fiber, Zingiber Officinale Root Extract, Laminaria Digitata Extract, Lactobacillus Ferment, Hyaluronic Acid, Caffeine, Oryzanol, Tocopherol, Acetyl Hexapeptide-8, Ethylhexylglycerin, Lecithin, Butylene Glycol, Resveratrol, Sorbitan Olivate, Chamomilla Recutita Oil Flower Matricaria Oil Flower, Peppermint Oil, Coriandrum Sativum Oil Fruit, Citrus Nobilis Peel Oil Mandarin Orange Peel Oil, Mimosa Tenuiflora Leaf Extract, Citrus Aurantium Dulcis Peel Oil, Bergamot Oil, Lemon Peel Oil, Rosa Damascena Flower Extract Rose Flower Extract, Rosa Damascena Oil Flower Rose Oil Flower, Michelia Alba Oil Flower, Copaifera Officinalis Resin, Ferula Galbaniflua Oil Resin, Jasminum Sambac Flower Extract Jasmine Flower Extract, Ricinus Communis Seed Oil Castor Seed Oil, Pelargonium Graveolens Oil Flower Geranium Oil Flower, Linalool, Citral, Limonene, Citronellol, Geraniol, Peg-40 Stearate, Xanthan Gum, Carbomer, Phenoxyethanol, Potassium Sorbate, Mica, Titanium Dioxide Ci 77891

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.