# Olay Regenerist Collagen Peptide 24 Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Olay Regenerist](https://lovi.care/skincare/es/brands/olay-regenerist)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin as niacinamide and glycerin provide humectant action and barrier repair, while Palmitoyl Pentapeptide-4 and Tremella Fuciformis Sporocarp Extract offer significant plumping and firming benefits for wrinkles and fine lines.
- The serum's formulation supports collagen production and skin barrier function, addressing your concerns about wrinkles and fine lines effectively.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like niacinamide and panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/oily-acne-prone-skin): High

## Key ingredients

Collagen Peptides, Niacinamide, Glycerin, Panthenol Vitamin B5, Tremella Fuciformis Sporocarp Extract

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Combined therapy using a topical hyaluronic acid-niacinamide-Matrixyl serum and a multimodal facial device decreased TruSkin age by five years and reduced wrinkles more effectively than the serum alone in a 41-year-old woman with moderate facial aging over 12 weeks. ([Cureus, 2026](https://pubmed.ncbi.nlm.nih.gov/42500768/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls. ([Frontiers in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38751975/))
- Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls. ([Journal of Agricultural and Food Chemistry, 2020](https://pubmed.ncbi.nlm.nih.gov/31967468/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Snow mushroom alcohol-based hand rub gel significantly improved skin moisture better than the placebo through 180 minutes while maintaining comparable antiseptic efficacy in 20 human volunteers. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32531816/))
- Tremella fuciformis extract demonstrates potential cutaneous benefits including skin antiaging, photoprotection, wound healing, and barrier protection based on in vitro and animal models. ([Archives of Dermatological Research, 2023](https://pubmed.ncbi.nlm.nih.gov/36757441/))
- Tremella fuciformis inhibits melanogenesis by decreasing melanin content and tyrosinase expression in B16F10 cells while promoting wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts. ([In Vivo, 2022](https://pubmed.ncbi.nlm.nih.gov/35241526/))

## What reviewers say

Based on a very large amount of data, this serum is widely praised for its lightweight, non-greasy texture and its ability to provide deep, lasting hydration. Users frequently report that it effectively plumps the skin, smooths fine lines, and improves overall radiance, making it a popular choice for those targeting signs of aging, dullness, and dehydration.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Fast absorbing (mostly mentioned)
- Liked: Lightweight feel (often mentioned)
- Liked: Plumps skin (often mentioned)
- Liked: Smooths texture (often mentioned)
- Disliked: Fiddly dropper (sometimes noted)
- Disliked: Limited tightening (rarely noted)
- Disliked: Price point (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Olay Collagen Peptide 24 Serum a great fit for mature skin?

This serum is a great fit for mature skin because ingredients like niacinamide and glycerin help keep skin hydrated and repair its barrier, while peptides and mushroom extract help smooth out wrinkles and fine lines. It is also very safe and gentle, using soothing ingredients to prevent irritation while supporting firmer skin.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Cureus, 2026](https://pubmed.ncbi.nlm.nih.gov/42500768/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains niacinamide and glycerin to hold in moisture, alongside collagen peptides and mushroom extract that help smooth out wrinkles and fine lines. It also includes panthenol to keep the skin calm and comfortable.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Cureus, 2026](https://pubmed.ncbi.nlm.nih.gov/42500768/)

### What do Collagen Peptides do for mature skin?

Collagen peptides help improve skin elasticity, hydration, and the appearance of wrinkles in mature skin with daily use over several weeks. Clinical studies show that this ingredient supports skin firmness by helping boost moisture and structural proteins.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26362110/), [Nutrients, 2023](https://pubmed.ncbi.nlm.nih.gov/37432180/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, following the simple steps for applying treatments. It is very unlikely to cause irritation and supports collagen production to help smooth fine lines.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to help keep your skin comfortable and smooth. This product supports your skin barrier and is unlikely to cause irritation when paired with retinol.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### How often should I use this serum?

Apply this serum in your evening routine for simplicity and extra safety around sun exposure. It helps smooth fine lines and plump mature skin with a very low likelihood of irritation.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Cureus, 2026](https://pubmed.ncbi.nlm.nih.gov/42500768/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin. It features a gentle formulation with soothing ingredients that keep the skin calm and comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €169.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Shiseido Benefiance Wrinkle Smoothing Cream](https://lovi.care/skincare/es/p/shiseido/benefiance-wrinkle-smoothing-cream-enriched/for/mature-skin) — Superior fit — €57.95 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Dimethicone, Niacinamide, Glycerin, Panthenol, Palmitoyl Pentapeptide-4, Tremella Fuciformis Sporocarp Extract, Hydroxyacetophenone, C13-14 Isoparaffin, Laureth-4, Polysorbate 20, Laureth-7, Disodium Edta, Polyacrylamide, Dimethicone Crosspolymer, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/olay-regenerist/collagen-peptide-24-serum/for/mature-skin