# numbuzin Pantothenic B5 Active Soothing Cream for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [numbuzin](https://lovi.care/skincare/es/brands/numbuzin)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration and soothing for your normal skin, as Panthenol and Glycerin provide humectant action, while Centella Asiatica Extract calms the skin.
- While the formulation is generally safe and beneficial for normal skin, it does not specifically target your main concern of pigmentation.
- The product has a good safety profile with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/oily-acne-prone-skin): High

## Key ingredients

Pantothenic Acid Vitamin B5, Niacinamide, Centella Asiatica Extract, Aloe Barbadensis Flower Extract, Glycerin

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol following PicoWay laser treatment decreased transepidermal water loss, increased hydration and skin elasticity, reduced wrinkles and redness, and improved skin tone in 88 Chinese females compared to a standard care control group. ([Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other moisturizers fit skin with dark spots better

- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## What reviewers say

Based on a very large amount of data, this lightweight gel-cream is widely celebrated by users with oily and acne-prone skin for its ability to hydrate without clogging pores or leaving a greasy residue. While it effectively soothes redness and controls excess sebum, users with dry or dehydrated skin often find it lacks sufficient moisture, particularly during colder months.

- Liked: Lightweight gel texture (mostly mentioned)
- Liked: Soothing & calming (often mentioned)
- Disliked: Insufficient moisture (often mentioned)
- Liked: Non-comedogenic (sometimes noted)
- Liked: Sebum/oil control (sometimes noted)
- Disliked: Breakouts/Reactions (rarely noted)
- Disliked: Packaging concerns (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Numbuzin Pantothenic B5 Cream work for skin with dark spots?

This cream works moderately well for your skin, though other products fit it better because it does not specifically target dark spots. A product for this skin needs effective brightening ingredients that align with your pigmentation goals along with moisturizing components.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this cream a good fit for skin with dark spots?

This cream is an average fit for skin with dark spots because it focuses on hydration and calming rather than fading pigmentation. To better target dark spots, a product of this type needs effective brightening ingredients alongside soothing and moisturizing components.

### What does Pantothenic Acid do for skin with dark spots?

Pantothenic acid, often used as panthenol, helps improve skin tone evenness and lightens hyperpigmentation when included in daily skincare routines. Clinical studies show that formulations containing this ingredient significantly reduce dark spots and improve overall facial skin texture over several weeks of consistent use.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2010](https://pubmed.ncbi.nlm.nih.gov/20061726/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this cream go in a skincare routine for skin with dark spots?

This cream goes in the morning after your hydrating toner and before your sunscreen, and in the evening as the final step after your treatment. Skincare for skin with dark spots needs targeted brighteners like vitamin C or niacinamide and gentle exfoliants to help fade discoloration and even out skin tone.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first, letting it absorb, and then following with this moisturizer to help soothe the skin and keep it calm. Using a gentle moisturizer alongside retinol is unlikely to cause irritation and helps support the skin barrier while you use stronger treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily to help keep your skin soft and calm. Regular daily application helps improve moisture levels and supports the skin barrier. Skin with dark spots needs a dedicated brightening treatment with ingredients like vitamin C, alpha-arbutin, or retinol.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for skin with dark spots?

This cream is unlikely to clog pores or cause breakouts on skin with dark spots, as user complaints about breakouts and reactions are low and it contains gentle, soothing ingredients. Skin with dark spots needs brightening ingredients like vitamin C or niacinamide to specifically fade spots while providing hydration.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because the skin around the eyes is among the thinnest while body skin is thicker, and this cream features a gentle formula with soothing components like panthenol and glycerin that provide safe hydration. For the thin skin around the eyes and on the body, a product of this type needs lightweight hydration, calming plant extracts, and barrier-supporting ingredients to maintain moisture without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/dark-spots) — High fit — €11.50 at Amazon
- [LANEIGE Water Bank Moisture Cream](https://lovi.care/skincare/es/p/laneige/water-bank-moisture-cream/for/dark-spots) — High fit — €56.63 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/es/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €11.30 at Amazon
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/es/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dark-spots) — Superior fit — €16.99 at Amazon

## Where to buy

- Amazon.de: €19.30 (https://www.amazon.de/dp/B0CXSM1K2F?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €24.15 (https://www.lookfantastic.es/p/numbuzin-no.1-pantothenic-b5-active-cream-80ml/17750370/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Butylene Glycol, Glycerin, Niacinamide, Cetyl Ethylhexanoate, Dicaprylyl Carbonate, 1,2-Hexanediol, Pentylene Glycol, Vinyl Dimethicone, Centella Asiatica Extract, Caprylyl Methicone, Erythritol, Panthenol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethiconol, Polymethylsilsesquioxane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Chlorella Vulgaris Extract, Glucose, Tromethamine, Silica, Fructooligosaccharides, Fructose, Sophora Angustifolia Root Extract, Ethylhexylglycerin, Xanthan Gum, Sodium Phytate, Glyceryl Acrylate Acrylic Acid Copolymer, Caprylic Capric Triglyceride, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Hydrogenated Lecithin, Ocimum Sanctum Leaf Extract, Tocopherol, Curcuma Longa Root Extract, Aloe Barbadensis Flower Extract, Solanum Melongena Fruit Extract, Decyl Glucoside, Corallina Officinalis Extract, Pantothenic Acid, Polyglyceryl-4 Caprate, Polyglyceryl-6 Caprylate, Camellia Sinensis Leaf Extract, Centella Asiatica Leaf Extract, Cladosiphon Okamuranus Extract, Willow Bark Extract, Houttuynia Cordata Extract, Coffea Arabica Seed Extract Coffee Seed Extract, Bergamot Leaf Extract, Pinus Densiflora Leaf Extract, Alpha-Arbutin, Zinc Pca, Argania Spinosa Kernel Oil, Methyl Diisopropyl Propionamide, Sesamum Indicum Seed Oil, Serenoa Serrulata Fruit Extract, Beta-Sitosterol, Glycyrrhiza Glabra Root Extract Licorice Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- France: https://lovi.care/skincare/fr/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots (this page)
- Canada: https://lovi.care/skincare/ca/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuzin/pantothenic-b5-active-soothing-cream/for/dark-spots