# Numbuzin No.2 Protein 43% Creamy Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Numbuzin](https://lovi.care/skincare/es/brands/numbuzin)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for oily skin as ceramide NP and cholesterol help repair the skin barrier, but it lacks sufficient sebum-regulating ingredients for optimal results on your oily skin.
- The protein ingredients provide general conditioning and hydration, which are beneficial but do not directly address your primary concerns of acne, blemishes, and breakouts.
- The product is safe for your oily skin, with no risk of irritation due to the absence of harsh ingredients and the inclusion of soothing components like hydrolyzed corn protein and ceramide NP.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Content Protein, Rice Seed Protein, Hydrolyzed Protein, Ceramide Np, Cholesterol

## What the research says

- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion. ([International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/))
- Topical application of oyster protein hydrolysates peptides protected against UVB-induced skin photodamage in mice by alleviating moisture loss, epidermal hyperplasia, and fiber degradation through antioxidant and anti-inflammatory mechanisms. ([Marine Drugs, 2020](https://pubmed.ncbi.nlm.nih.gov/32486363/))
- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Combined treatment with human umbilical cord mesenchymal stem cell-derived exosomes and hydrolyzed collagen oligopeptides enhanced proliferation and migration, reduced reactive oxygen species and senescence-associated beta-galactosidase activity, increased type I and type III collagen expression, and decreased metalloproteinases, inflammatory cytokines, and senescence markers in human skin fibroblasts compared to either treatment alone. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/))
- Collagen peptides induced cell proliferation and pro-collagen-1α expression, increased TGF-β and VEGF, and suppressed the LPS-induced inflammatory response in human skin fibroblasts and keratinocytes. ([Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/))
- Botulinum toxin-A encapsulated in phosphatidylcholine/cholesterol nanoliposomes delivered transdermally achieved a diffusion depth of 380 μm and showed a nonsignificant advantage in relieving post-acne scarring compared to hyaluronic acid hydrogel treatment in 12 facial patients. ([Journal of Materials Science. Materials in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39073502/))
- Topical application of cholesterol sulfate increases stratum corneum thickness and inhibits protease-induced cell dissociation by competitively inhibiting serine proteases in mice and human stratum corneum. ([The Journal of Investigative Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9699715/))
- Topical lovastatin treatment impairs the recovery of cutaneous permeability barrier function and stratum corneum cholesterol levels after acetone disruption in mice, an effect normalized by simultaneous treatment with mevalonate or cholesterol. ([The Journal of Clinical Investigation, 1990](https://pubmed.ncbi.nlm.nih.gov/2243142/))

## Why other moisturizers fit oily acne-prone skin better

- A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31347768/))
- Epigallocatechin-3-gallate significantly improved acne in patients compared to the control side during an 8-week clinical trial. ([The Journal of Investigative Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23096708/))
- A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28342238/))

## What reviewers say

This serum is widely praised as a "winter savior" for dry, sensitive, and dehydrated skin, effectively repairing damaged barriers and alleviating flakiness. Users consistently report a plump, healthy glow and deep "inner" hydration, though its rich, protein-heavy formula can be too heavy or potentially pore-clogging for oily or acne-prone skin types.

- Liked: Deep barrier repair (mostly mentioned)
- Liked: Long-lasting hydration (often mentioned)
- Liked: Rich creamy texture (often mentioned)
- Liked: Glowy finish (sometimes noted)
- Disliked: Not for oily skin (sometimes noted)
- Disliked: Potential breakouts (sometimes noted)
- Disliked: Stickiness/tackiness (sometimes noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Numbuzin No.2 Protein 43% Creamy Serum work for oily acne-prone skin?

This moisturizing treatment works moderately well for your oily acne-prone skin, as ceramide NP and cholesterol help repair your skin barrier, though it lacks sufficient oil-controlling ingredients. While the proteins provide general conditioning, an option for this skin needs ingredients that regulate oil production and provide anti-inflammatory benefits for acne and blemishes.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Ceramide NP and cholesterol help repair the skin barrier, while proteins provide general conditioning and hydration. However, a product for oily acne-prone skin needs ingredients that help regulate oil, calm breakouts, and provide lightweight hydration without heavy oils.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/), [International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/)

### What does Content Protein do for oily acne-prone skin?

Content Protein helps calm oily, acne-prone skin by improving skin barrier function and reducing acne symptoms like blemishes and excess oil. It is unlikely to cause irritation and works to keep the skin smooth and balanced.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32697858/), [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41329150/)

### What does Rice Seed Protein do for oily acne-prone skin?

Rice Seed Protein helps calm oily, acne-prone skin by soothing irritation and supporting a smooth, soft feel without clogging pores. This ingredient is unlikely to cause heavy buildup, making it a great addition to lightweight daily routines.

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in the evening routine as a treatment step before your moisturizer, keeping things simple and safe around sun exposure. While ceramide NP and cholesterol help repair the skin barrier, this skin type needs oil-balancing ingredients and blemish-targeting actives for optimal results.

### Can I use this serum with niacinamide, and in what order?

Yes, you can use this serum with niacinamide by applying niacinamide first to target blemishes and oil, followed by this serum to hydrate and calm the skin. This product works well for your skin type, though oily acne-prone skin needs ingredients that control oil and target breakouts for the best results.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### How often should I use this serum?

You can use this serum twice a day as part of your morning and evening routine, though a product for oily acne-prone skin also needs oil-controlling and breakout-targeting ingredients to work best.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum may cause breakouts on oily acne-prone skin, as reviewers moderately report this issue. While ceramide NP and cholesterol help repair the skin barrier safely without irritation, the formula lacks sufficient oil-controlling ingredients to manage breakouts properly.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Can I use this serum around the eyes or on my body?

You can safely use this moisturizing treatment on the body and around the eyes, where the skin is particularly thin. Ceramide NP and cholesterol help repair the skin barrier and maintain hydration in these areas without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/es/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/oily-acne-prone-skin) — Superior fit — €6.30 at Notino
- [SkinCeuticals Hydrating B5 Gel](https://lovi.care/skincare/es/p/skinceuticals/hydrating-b5-gel/for/oily-acne-prone-skin) — High fit — €101.20 at Lookfantastic

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- SPF: [Dear, Klairs All-day Airy Sunscreen](https://lovi.care/skincare/es/p/dear-klairs/all-day-airy-sunscreen/for/oily-acne-prone-skin) — Superior fit — €21.00 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Voat Extract Protein, Water, Cyclopentasiloxane, Butylene Glycol, Cetearyl Ethyl Hexanoate, Cyclohexasiloxane, Phenyl Trimethicone, Cetyl Pg, Sebum-10 1 Dimethicone, Hydrogenate Tid Poly, Rice Seed Protein, Prunus Amygdalus Dulcis Protein, Hydrolyzed Corn Protein, Hydrolyzed Protein, Hydrolyzed Pea Protein, Hydrolyzed Milk Protein, Glycine Soja Protein Soybean Protein, Hydrolyzed Lupine Protein, Ceramide Np, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-acne-prone-skin
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