# Neora Advanced SIG-1273 Concentrated Serum for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Neora](https://lovi.care/skincare/es/brands/neora)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- This product offers moderate hydration for your normal skin, as glycerin and sodium hyaluronate provide humectant action to retain moisture.
- While suitable for normal skin, the ingredients do not directly address your primary concern of pigmentation.
- The formula is safe for your skin, with no harsh ingredients or irritation risks.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Glycerin, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentylene Glycol, Citric Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone. ([Dermatologic Surgery, 1997](https://pubmed.ncbi.nlm.nih.gov/9256916/))

## Why other serums fit skin with dark spots better

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on limited data, users describe the serum as a lightweight, hydrating formula that leaves skin feeling smooth and looking radiant. While many report improvements in skin texture and a healthy glow, some users feel the anti-aging results are subtle rather than dramatic, especially when weighed against the product's premium price point.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating effect (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Radiant glow (sometimes noted)
- Liked: Smoother skin (sometimes noted)
- Disliked: MLM model (sometimes noted)
- Disliked: Subtle results (sometimes noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Neora Advanced SIG-1273 Concentrated Serum work for skin with dark spots?

This serum works moderately well for your skin, providing nice moisture with sodium hyaluronate and glycerin, but it does not directly target dark spots. A treatment for this skin needs effective antioxidants and soothing ingredients like niacinamide and propolis to fade dark spots without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum is only an average fit for skin with dark spots because its ingredients do not directly address dark spots, though it does provide moisture with glycerin and sodium hyaluronate. A treatment for dark spots needs a blend of effective antioxidants, soothing ingredients, and brightening components like niacinamide and propolis to fade dark spots and boost radiance without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for skin with dark spots?

Hyaluronic acid is unlikely to directly fade dark spots, but it helps keep dry and uneven skin plump and deeply hydrated. To effectively target dark spots, this type of skin needs brightening ingredients like vitamin C or niacinamide alongside your hydrator.

### What does Glycerin do for skin with dark spots?

Glycerin helps keep dry skin hydrated and supports a healthy skin barrier, which makes skin feel soft and smooth. While it does not directly fade dark spots on its own, it is often added to spot-fading products to keep the skin comfortable while other ingredients work.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine, after cleansing and before moisturizing, for simplicity and extra safety around sun exposure. Skin with dark spots needs brightening ingredients like vitamin C, retinoids, or targeted peptides to effectively fade discoloration.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin moisture, followed by your retinol. The formula is unlikely to irritate your skin, but since it does not target dark spots, this skin also needs ingredients that fade discoloration and brighten uneven tone.

### How often should I use this serum?

This serum works best in your evening routine, as treatments fit best there for simplicity and extra safety around sun exposure. Since it offers moderate moisture and is safe for your skin but does not directly target dark spots, this skin needs ingredients and products that actively fade pigmentation.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts since its formula is safe with no harsh ingredients or irritation risks. It provides moderate moisture for normal skin, but a product for dark spots needs targeted brightening ingredients to properly fade discoloration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/es/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €122.90 at Amazon
- [The Ordinary Buffet + Copper Peptides 1%](https://lovi.care/skincare/es/p/the-ordinary/buffet-copper-peptides-1/for/dark-spots) — High fit — €29.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/es/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €11.30 at Amazon
- Moisturizer: [Torriden DIVE-IN Low Molecule Hyaluronic Acid Multi Pad](https://lovi.care/skincare/es/p/torriden/dive-in-low-molecule-hyaluronic-acid-multi-pad/for/dark-spots) — Superior fit — €17.90 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots (this page)
- Canada: https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots