# Neora Advanced SIG-1273 Concentrated Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Neora](https://lovi.care/skincare/es/brands/neora)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Moderate hydration is offered due to the presence of glycerin and sodium hyaluronate, which are highly suitable for your combination skin by providing humectant action.
- While these ingredients offer general skincare benefits, they are mostly supportive and irrelevant for your primary concerns of acne, blemishes, and breakouts.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Glycerin, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentylene Glycol, Citric Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone. ([Dermatologic Surgery, 1997](https://pubmed.ncbi.nlm.nih.gov/9256916/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on limited data, users describe the serum as a lightweight, hydrating formula that leaves skin feeling smooth and looking radiant. While many report improvements in skin texture and a healthy glow, some users feel the anti-aging results are subtle rather than dramatic, especially when weighed against the product's premium price point.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating effect (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Radiant glow (sometimes noted)
- Liked: Smoother skin (sometimes noted)
- Disliked: MLM model (sometimes noted)
- Disliked: Subtle results (sometimes noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Neora SIG-1273 Concentrated Serum work for acne-prone skin?

This serum offers moderate hydration, but its ingredients are mostly supportive and do not target acne, blemishes, or breakouts. It has a very safe profile with no harsh ingredients, though a treatment for acne-prone skin needs effective ingredients like niacinamide, propolis, or zinc PCA that help control oiliness and breakouts without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum offers moderate hydration for your acne-prone skin because it contains glycerin and sodium hyaluronate, which help keep your skin soft and smooth. However, these ingredients are mostly supportive and do not target breakouts, meaning this product needs ingredients like niacinamide, propolis, or zinc PCA to truly fit acne-prone skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [International Journal of Toxicology, 2019](https://pubmed.ncbi.nlm.nih.gov/31840548/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in your evening routine, as treatments with active ingredients are typically used then for simplicity and extra safety around sun exposure. While it provides moderate hydration, an acne-prone skin type needs targeted ingredients like salicylic acid or benzoyl peroxide to effectively manage breakouts.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin light hydration, followed by your retinol. This product is unlikely to cause irritation because it avoids harsh ingredients, but acne-prone skin needs treatments that specifically target breakouts and blemishes.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Products of this type for acne-prone skin need targeted ingredients that clear breakouts and soothe blemishes.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or clog pores because it lacks harsh or irritating ingredients. However, it does not actively target acne, so acne-prone skin needs a treatment containing ingredients like salicylic acid or benzoyl peroxide to truly clear and prevent blemishes.

## Alternatives for acne-prone skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — €29.76 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €17.49 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin