# NATURIUM Niacinamide Serum 12% Plus Zinc 2% for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [NATURIUM](https://lovi.care/skincare/es/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Offers excellent pore cleansing and oil control for your dry skin, as niacinamide and zinc PCA work to decongest pores and mattify oily areas, while glycerin and sodium hyaluronate provide essential hydration.
- The serum's formulation includes niacinamide and glycerin, which are beneficial for dry or flaky skin by offering humectant action to improve moisture retention.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Zinc Pca, Sodium Hyaluronate, Tocopheryl Acetate Vitamin E, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Zinc PCA inhibits UVA-induced matrix metalloproteinase-1 production through suppressed AP-1 activation and enhances type I collagen synthesis by increasing SVCT2 mRNA expression in cultured normal human dermal fibroblasts. ([International Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/21834944/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective for oily and acne-prone skin, with users frequently reporting minimized pores, controlled oil production, and smoother skin texture. Some users, particularly those with sensitive skin, experience irritation, stinging, or breakouts due to the high concentration of niacinamide. A small number of users also noted a sticky residue or saw no visible results.

- Liked: Controls oil (mostly mentioned)
- Liked: Lightweight, absorbs fast (often mentioned)
- Liked: Minimizes pores (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Brightens tone (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Too strong (sometimes noted)
- Disliked: Causes irritation (rarely noted)
- Disliked: No results (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Naturium Niacinamide Serum 12% Plus Zinc 2% a great fit for dry skin?

This serum is a great fit for your dry skin because it pairs deep hydration from glycerin and sodium hyaluronate with pore-cleansing niacinamide and zinc PCA. It helps improve moisture retention and leaves your skin feeling comfortable without any irritation, thanks to its very safe and soothing formula.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for dry skin because it contains glycerin and sodium hyaluronate to bring in moisture, alongside niacinamide to help keep that moisture locked in. These ingredients work together to give you smooth, comfortable skin while keeping irritation away with very low risk.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### What does Zinc PCA do for dry skin?

Zinc PCA helps oily skin by keeping oil levels balanced, but it is not typically used for dry skin. Dry skin needs ingredients that add moisture and soothe dryness, rather than ingredients meant to control oil.

### Where does this serum go in a skincare routine for dry skin?

This serum goes in your evening routine after cleansing and before moisturizing, which keeps things simple and safe. It is unlikely to cause irritation for your dry skin because it leaves out harsh ingredients and includes soothing components.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first and following with your retinol, or alternating nights if your skin feels sensitive. This helps manage dryness while keeping your skin calm, as the formula is unlikely to cause irritation and includes hydrating ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### How often should I use this serum?

Apply this treatment in the evening as part of your routine. It is unlikely to irritate dry skin and helps improve moisture retention.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin, as its safe formula includes soothing components and lacks harsh ingredients. However, some reviewers do mention breakouts, and vitamin E derivatives in the formula have a low risk of forming microcomedones.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/dry-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €8.85 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/dry-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/es/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

- Amazon.de: €23.90 (https://www.amazon.de/dp/B07WSS5M4Z?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Niacinamide, Propanediol, Glycerin, Zinc Pca, Polyacrylate Crosspolymer-11, Sodium Hyaluronate, Dimethicone, Caprylyl Glycol, Phenoxyethanol, Xanthan Gum, Potassium Sorbate, Glyceryl Polyacrylate, Tocopheryl Acetate, Hexylene Glycol, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- France: https://lovi.care/skincare/fr/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin