# NATURIUM Multi-Peptide Moisturizer for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [NATURIUM](https://lovi.care/skincare/es/brands/naturium)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- This formulation is highly suitable for your normal skin, as glycerin and sodium hyaluronate provide excellent humectant action, while squalane and jojoba seed oil offer emollient benefits that hydrate and plump your skin.
- The inclusion of peptides like Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1, and Palmitoyl Tetrapeptide-7 supports collagen production and skin elasticity, directly addressing your concerns about wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/oily-acne-prone-skin): High

## Key ingredients

Multi-Peptide Blend, 3-O-Ethyl Ascorbic Acid Ethylated Vitamin C, Panthenol Vitamin B5, Squalane, Niacinamide

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects. ([Dermatology and Therapy, 2026](https://pubmed.ncbi.nlm.nih.gov/42322532/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## What reviewers say

This moisturizer is highly praised for its lightweight and absorbent texture, making it suitable for oily and combination skin types. It effectively plumps fine lines and improves skin texture, providing a smooth base for makeup. However, users with very dry skin may find it insufficient for their hydration needs and might require additional layering. A small number of reviews mention issues with the pump packaging or experiencing breakouts.

- Liked: Lightweight & Absorbent (mostly mentioned)
- Liked: Makeup Compatibility (often mentioned)
- Liked: Sanitary Packaging (sometimes noted)
- Liked: Skin Texture & Plumping (sometimes noted)
- Liked: Value for Money (sometimes noted)
- Disliked: Not hydrating enough (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Packaging malfunctions (rarely noted)
- Disliked: Pilling issues (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Naturium Multi-Peptide Moisturizer a great fit for mature skin?

This moisturizer is a great fit because it contains peptides like palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 that help support collagen production and skin elasticity to address wrinkles and fine lines. It also includes ingredients like glycerin and sodium hyaluronate to hydrate and plump your skin.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because its multi-peptide blend supports collagen production and firmness, while ingredients like squalane and glycerin hydrate and plump the skin. These components help smooth fine lines and wrinkles while keeping the skin soft and calm.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### What do Peptides do for mature skin?

Peptides help smooth fine lines and make mature skin feel firmer and more elastic by encouraging collagen production. They also improve skin hydration and help repair signs of aging.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/), [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19570099/)

### What does 3-O-Ethyl Ascorbic Acid do for mature skin?

3-O-Ethyl Ascorbic Acid helps keep mature skin firm and bright by supporting collagen production and improving overall skin tone. It may also protect skin cells from everyday environmental stress and damage.
Sources: [The Journal of Investigative Dermatology, 1994](https://pubmed.ncbi.nlm.nih.gov/7518857/), [Life, 2021](https://pubmed.ncbi.nlm.nih.gov/33946734/)

### Where does this cream go in a skincare routine for mature skin?

NATURIUM Multi-Peptide Moisturizer goes in the morning routine after a hydrating toner and before SPF, and in the evening routine after your treatment. This helps lock in hydration and supports your skin with soothing ingredients that are unlikely to cause irritation.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol, and applying it before your retinol helps soothe your skin and keeps it calm while the retinol works. A moisturizer with barrier-supporting ingredients is unlikely to cause irritation and may make it easier for your skin to adjust to retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your morning and evening routine to keep your mature skin hydrated and smooth. Regular daily application helps improve skin texture and firmness while reducing the look of fine lines and wrinkles over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause breakouts or irritation, as it has a very safe profile and soothing ingredients. It features a gentle formulation that helps hydrate and plump your skin without harsh additives.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because its gentle formulation has a very low likelihood of irritation. Its rich blend of peptides and hydrating ingredients helps soften and smooth delicate areas safely.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol and stearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/es/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €59.99 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/mature-skin) — Superior fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €11.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Bioré UV Perfect Milk SPF 50+ PA++++](https://lovi.care/skincare/es/p/biore/uv-face-milk-spf50-pa/for/mature-skin) — Superior fit — €25.88 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Dimethicone, Jojoba Seed Oil, Squalane, Glyceryl Stearate, Cetyl Alcohol, Niacinamide, Stearyl Alcohol, Palmitoyl Tripeptide-5, Pantolactone, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydrolyzed Plukenetia Volubilis Seed Extract, Dunaliella Salina Extract, Sodium Hyaluronate, 3-O-Ethyl Ascorbic Acid, Panthenol, Caryodendron Orinocense Seed Oil, Honokiol, Magnolol, Palmitic Acid, Sorbitan Oleate, Aluminum Octenylsuccinate Starch, Hydroxyacetophenone, Stearic Acid, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Polyglyceryl-6 Laurate, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Polyglyceryl-10 Oleate, Isohexadecane, Butylene Glycol, Chlorphenesin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tocopheryl Acetate, Polysorbate 80, Sorbitan Palmitate, Sodium Hydroxide, Sodium Benzoate, Carbomer, Sodium Lactate, Phenoxyethanol, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Potassium Sorbate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/multi-peptide-moisturizer/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/naturium/multi-peptide-moisturizer/for/mature-skin
- France: https://lovi.care/skincare/fr/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/multi-peptide-moisturizer/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/multi-peptide-moisturizer/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/multi-peptide-moisturizer/for/mature-skin