# NATURIUM Multi-Peptide Advanced Serum for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [NATURIUM](https://lovi.care/skincare/es/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Offers moderate benefits for your dry or flaky skin due to the presence of squalane and hydrolyzed collagen, which hydrate and support your skin barrier. Acetyl hexapeptide-8 and copper palmitoyl heptapeptide-14 also work to minimize fine lines and wrinkles.
- Butyrospermum parkii butter shea butter provides emollient action and barrier repair, making it highly suitable for your dry skin type.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the presence of soothing agents like sunflower and rosemary leaf extracts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Multi-Peptide Blend, Ferulic Acid, Hydrolyzed Collagen, Squalane, Acetyl Hexapeptide-8

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects. ([Dermatology and Therapy, 2026](https://pubmed.ncbi.nlm.nih.gov/42322532/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))

## What reviewers say

Users with dry, mature, and sensitive skin frequently praise this serum for its ability to visibly plump fine lines and deliver a "glass-skin" radiance without irritation. Many report smoother texture and improved hydration, while a minority of users experienced breakouts or frustration with the packaging design.

- Liked: Elegant texture (often mentioned)
- Liked: Hydrating and plumping (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Great value (sometimes noted)
- Liked: Visible anti-aging (sometimes noted)
- Disliked: Poor pump design (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Runs out quickly (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Naturium Multi-Peptide Advanced Serum a great fit for dry skin?

This serum is a great fit because it contains squalane, hydrolyzed collagen, and shea butter, which help hydrate and repair your skin barrier. It also features peptides that may smooth out fine lines and wrinkles while keeping your skin calm and soft.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for dry skin?

Squalane, hydrolyzed collagen, and shea butter make this serum a great fit by hydrating dry skin, supporting the skin barrier, and providing soothing moisture. Peptides like acetyl hexapeptide-8 also help smooth out fine lines.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What do Peptides do for dry skin?

Peptides help boost skin hydration and elasticity while reducing dryness and smoothing the skin. Daily use of a peptide serum may improve moisture levels and help keep dry skin soft and firm.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/)

### What does Ferulic Acid do for dry skin?

Ferulic acid helps keep dry skin hydrated and supports the skin barrier. It helps lock in moisture to reduce dryness and keep the skin feeling soft and smooth.
Sources: [International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie Et de Nutrition, 2023](https://pubmed.ncbi.nlm.nih.gov/33973806/), [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31213870/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening provides simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first, letting it absorb, and then following with your retinol. This approach helps minimize potential dryness while delivering peptides and soothing ingredients to your skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### How often should I use this serum?

You can use this serum in your evening routine, applying it after cleansing and before your moisturizer. It is unlikely to irritate dry skin and helps smooth fine lines while keeping your skin hydrated.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin, as it has an excellent safety profile and only a low risk of breakouts reported by reviewers. Soothing plant extracts help keep your skin calm while peptides and squalane hydrate and smooth without heavy clogging.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/dry-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €8.85 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/dry-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/es/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Caprylic Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter Shea Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract Sunflower Extract, Rice Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Hexapeptide-13 Serine Sp Amide, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Lactic Acid Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/dry-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/multi-peptide-advanced-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/dry-skin