# Mediheal A:PE Protain Mask for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Mediheal](https://lovi.care/skincare/es/brands/mediheal)
Category: [Face masks](https://lovi.care/skincare/es/best/face-masks)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best nourishing masks for acne-prone skin.

## Why this fit

- Offers moderate benefits for your acne, blemishes, and breakouts due to niacinamide and willow bark extract, which help regulate sebum and provide mild exfoliation, complementing your combination skin by balancing oily and dry areas.
- The formulation provides excellent nourishment and anti-aging effects with high concentrations of milk protein and acetyl hexapeptide-8, enhancing skin conditioning.
- It is safe for your acne-prone skin, as it contains soothing Centella Asiatica Extract and lacks harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Hydrolyzed Collagen, Sodium Hyaluronate, Centella Asiatica Extract, Squalane

## What the research says

- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users with dry, sensitive, or compromised skin barriers report excellent outcomes, praising the mask for its rich, creamy essence that deeply moisturizes and calms redness. While highly effective for soothing irritation and flattening pimples, the heavy, milky texture can be too rich or sticky for those with oily or acne-prone skin.

- Liked: Rich hydration (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Soft adherent sheet (often mentioned)
- Disliked: Heavy sticky finish (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Disliked: Artificial fragrance (rarely noted)
- Disliked: Fit issues (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start using your sheet mask 3 times a week, and build up to daily use if your skin likes it.
- Apply your sheet mask after cleansing and toning, but before putting on your moisturizer. Relax with it on for ten to fifteen minutes.
- Take the sheet mask out and gently smooth it over your face so it fits well. Pat any leftover essence into your skin without rubbing.
- Put the sheet mask on clean and dry skin for the best comfort. This helps your pores take in all the good ingredients.
- Avoid getting the product too close to your sensitive eye area. Do a small patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/cf9cbc1593b43309df7ca9cfe4fbbdae.mp4

## Questions and answers

### What makes Mediheal A:PE Protain Mask a great fit for acne-prone skin?

This mask is a great fit because it helps calm breakouts and balance oily and dry areas with ingredients like niacinamide and willow bark extract. It is very safe for acne-prone skin, as it contains soothing centella asiatica extract and lacks harsh ingredients that may cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this mask a good fit for acne-prone skin?

This mask is a great fit for your acne-prone skin because it contains niacinamide and willow bark extract, which help balance oil and calm breakouts, along with soothing Centella Asiatica extract. It is safe for this skin type and is unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Hydrolyzed Collagen do for acne-prone skin?

Hydrolyzed Collagen is unlikely to treat acne directly, but it may help improve overall skin hydration and elasticity as part of your routine. This type of product needs added ingredients like niacinamide or soothing plant extracts to effectively calm breakouts and care for acne-prone skin.
Sources: [International Journal of Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33742704/)

### Where does this mask go in a skincare routine for acne-prone skin?

This nourishing mask is a great fit for your acne-prone skin and is best used as an extra weekly step after cleansing and toning. It helps balance oily and dry areas and keeps skin calm while offering nourishing and anti-aging benefits.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can I use this mask with retinol, and in what order?

You can use this nourishing mask with retinol to help keep your skin calm and moisturized. Apply the mask after your retinol treatment, or use it on nights you skip retinol to help your skin stay soft and smooth.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this mask?

This nourishing mask is a great fit for your acne-prone skin and can be used regularly to help balance oily and dry areas while providing soothing care. It is safe and unlikely to cause irritation due to its calming ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can this mask clog pores, cause breakouts or purging for acne-prone skin?

This mask is safe for your acne-prone skin because it contains soothing Centella Asiatica extract and is free from harsh ingredients that could cause irritation. It helps balance oily and dry areas while providing nourishment without clogging pores.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this mask fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [Pyunkang Yul Ceramide Calming Mask Pack](https://lovi.care/skincare/es/p/pyunkang-yul/ceramide-calming-mask-pack/for/acne-prone-skin) — High fit — €17.99 at Amazon
- [Dr. Jart+ Ceramidin Facial Barrier Mask](https://lovi.care/skincare/es/p/dr-jart/ceramidin-facial-barrier-mask/for/acne-prone-skin) — High fit — €5.77 at Amazon
- [Numbuzin No.2 Water Collagen 65% Voluming Sheet Mask](https://lovi.care/skincare/es/p/numbuzin/no-2-water-collagen-65-voluming-sheet-mask/for/acne-prone-skin) — High fit — €14.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €17.49 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Dipropylene Glycol, Niacinamide, Propylene Glycol, Cetearyl Alcohol, Squalane, Glycerin, Hydrogenated Lecithin, C12-16 Alcohols, Palmitic Acid, Dipotassium Glycyrrhizate, Lactobacillus Eriodictyon Californicum Extract Ferment, Lactobacillus Soybean Extract Ferment, Centella Asiatica Extract, Origanum Vulgare Leaf Extract, Cinnamomum Cassia Bark Extract, Vitex Agnus Castus Extract, Chamomilla Recutita Extract Matricaria Extract, Chamaecyparis Obtusa Leaf Extract, Peg-12 Dimethicone, Hydroxyethyl Urea, Willow Bark Extract, Scutellaria Baicalensis Root Extract, Betaine, Bifida Ferment Filtrate, Pentylene Glycol, Xylitylglucoside, Adenosine, Anhydroxylitol, Leontopodium Alpinum Callus Culture Extract, Xylitol, Dimethicone, Extract Milk Protein, Tocopheryl Acetate, Hydrolyzed Collagen, Sodium Hyaluronate, Glucose, Portulaca Oleracea Extract, Butylene Glycol, Glycine, Serine, Glutamic Acid, Aspartic Acid, Leucine, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Valine, Threonine, Proline, Isoleucine, Histidine, Methionine, Cysteine, Acetyl Hexapeptide-8, Phenoxyethanol, Copper Tripeptide-1, Ethylhexylglycerin, Disodium Edta, Carbomer, 1,2-Hexanediol, Zanthoxylum Piperitum Fruit Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/a-pe-protain-mask/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/a-pe-protain-mask/for/acne-prone-skin