# Medicube Zero Pore Serum 2.0 for oily acne-prone skin

**Lovi Fit: Caution fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Concerning.

Page: https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Medicube](https://lovi.care/skincare/es/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A poor match for oily acne-prone skin; the serums alongside fit it better.

## Why this fit

- Offers moderate pore treatment for your oily skin due to Cinnamomum Zeylanicum Bark Extract and Fomes Officinalis Extract, which help decongest pores and regulate sebum. Mentha Rotundifolia Leaf Extract and Citrus Aurantifolia Peel Extract provide additional cleansing benefits, supporting your goal of managing oiliness.
- While the formula offers general hydration and soothing effects, its primary benefits are not directly targeted at your acne, blemishes, and breakouts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin): Caution (this page)

## Key ingredients

Dimethicone, Mentha Rotundifolia Leaf Extract, Citrus Aurantifolia Peel Extract, Fomes Officinalis Extract Mushroom Extract

## What the research says

- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- Aqueous extracts of apple mint leaves inhibited heat shock-induced production of reactive oxygen species, matrix metalloproteinases, interleukin-8, and mitogen-activated protein kinases in human dermal fibroblasts. ([Evidence-based Complementary and Alternative Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/30254686/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## What reviewers say

Users with oily and combination skin frequently report that this serum effectively regulates sebum and improves overall skin texture, creating a smoother base for makeup. While many users noticed a visible tightening of pores and a "glass skin" effect, results regarding actual pore size reduction are mixed, with some finding it highly effective and others seeing no significant change.

- Liked: Smoother skin texture (mostly mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Oil & sebum control (often mentioned)
- Disliked: Sticky texture (often mentioned)
- Liked: Pore tightening (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Unpleasant fragrance (sometimes noted)
- Disliked: Price vs. quantity (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why does Lovi advise caution with Medicube Zero Pore Serum for oily acne-prone skin?

Lovi advises caution because this serum focuses mainly on pores and oil rather than targeting acne and breakouts directly. An effective choice for this skin type needs safe, non-irritating ingredients that tackle blemishes clearly while keeping skin calm and non-greasy.
Sources: [Ostomy/wound Management, 2005](https://pubmed.ncbi.nlm.nih.gov/16439809/), [Evidence-based Complementary and Alternative Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/30254686/)

### Which ingredients make this serum a poor fit for oily acne-prone skin?

This serum is a poor fit for oily acne-prone skin because it contains dimethicone and other heavy texture ingredients that can overwhelm skin prone to breakouts, as these silicones have shown limited performance in barrier and protection tests compared to lighter options. A treatment for this skin needs effective, non-irritating ingredients like niacinamide and soothing fermented extracts that clear blemishes and enhance clarity without adding heaviness.
Sources: [Ostomy/wound Management, 2005](https://pubmed.ncbi.nlm.nih.gov/16439809/)

### What does Water do for oily acne-prone skin?

Water helps keep oily, acne-prone skin hydrated without making it greasy. Keeping skin hydrated is important because acne treatments can dry it out and irritate the skin barrier.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40196957/)

### What does Dimethicone do for oily acne-prone skin?

Dimethicone helps protect oily, acne-prone skin from irritation, but it shows varying performance in keeping skin hydrated compared to other protectants. Because it can feel heavy, this type of skin often needs lighter ingredients like natural plant oils with a higher linoleic acid to oleic acid ratio to keep pores clear and the skin barrier strong.
Sources: [Ostomy/wound Management, 2005](https://pubmed.ncbi.nlm.nih.gov/16439809/), [Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Because it is a poor match for your oily acne-prone skin, a product of this type needs ingredients that directly target acne, blemishes, and breakouts.

### Can I use this serum with niacinamide, and in what order?

You can use this serum with niacinamide, applying the niacinamide first and letting it absorb before layering this treatment on top. This order helps keep your oily skin balanced while minimizing irritation. Oily acne-prone skin needs a treatment that directly targets breakouts and blemishes with proven acne-fighting ingredients alongside pore-clearing extracts.

### How often should I use this serum?

This serum is a poor match for your oily acne-prone skin, as it lacks targeted ingredients for breakouts; oily acne-prone skin needs acne-fighting ingredients like salicylic acid, benzoyl peroxide, or retinoids to clear blemishes and prevent clogged pores. When used on this skin, apply it in the evening as a treatment step, starting once a week and only increasing frequency if your skin tolerates it well.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum may not cause purging since it does not contain exfoliating acids, but its heavy silicones can sometimes clog pores on blemish-prone skin. A product of this type needs lightweight, non-greasy hydrators and targeted blemish-fighting ingredients to properly care for oily skin.
Sources: [Ostomy/wound Management, 2005](https://pubmed.ncbi.nlm.nih.gov/16439809/), [Evidence-based Complementary and Alternative Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/30254686/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [SKIN1004 Madagascar Centella Asiatica Ampoule](https://lovi.care/skincare/es/p/skin1004/madagascar-centella-asiatica-ampoule/for/oily-acne-prone-skin) — High fit — €13.88 at Amazon
- [Purito Galacto Niacin 97 Power Essence](https://lovi.care/skincare/es/p/purito/galacto-niacin-97-power-essence/for/oily-acne-prone-skin) — High fit — €18.95 at Amazon

## Routine for oily acne-prone skin

### AM

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- SPF: [Dear, Klairs All-day Airy Sunscreen](https://lovi.care/skincare/es/p/dear-klairs/all-day-airy-sunscreen/for/oily-acne-prone-skin) — Superior fit — €21.00 at Amazon

### PM

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/es/p/pyunkang-yul/deep-cleansing-oil/for/oily-acne-prone-skin) — Superior fit — €18.99 at Amazon
- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €20.50 at Amazon
- Cleansing Toner: [Caudalie Vinopure Clear Skin Purifying Toner](https://lovi.care/skincare/es/p/caudalie/vinopure-purifying-toner/for/oily-acne-prone-skin) — Superior fit — €16.90 at Amazon
- Serum or Treatment: [The Ordinary Niacinamide 10% + Zinc 1%](https://lovi.care/skincare/es/p/the-ordinary/niacinamide-10-zinc-1/for/oily-acne-prone-skin) — Superior fit — €5.20 at Amazon

### Weekly

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/es/p/pyunkang-yul/deep-cleansing-oil/for/oily-acne-prone-skin) — Superior fit — €18.99 at Amazon
- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €20.50 at Amazon
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/es/p/dermalogica/daily-microfoliant/for/oily-acne-prone-skin) — Superior fit — €48.55 at Amazon
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/es/p/vt-cosmetics/cica-purifying-mask/for/oily-acne-prone-skin) — High fit — €16.79 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Serum or Treatment: [The Ordinary Niacinamide 10% + Zinc 1%](https://lovi.care/skincare/es/p/the-ordinary/niacinamide-10-zinc-1/for/oily-acne-prone-skin) — Superior fit — €5.20 at Amazon

## Where to buy

- Amazon.de: €21.99 (https://www.amazon.de/dp/B09G267W27?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €24.50 (https://www.notino.es/medicube/zero-pore-serum-2-0-serum-para-pieles-grasas-y-problematicas-para-reducir-la-piel-grasa-del-rostro/p-16329871/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Cyclopentasiloxane, Cetyl Ethylhexanoate, Cyclohexasiloxane, Polysorbate 60, Bis-Peg-18 Methyl Ether Dimethyl Silane, Glyceryl Stearate, Dimethicone, Peg-100 Stearate, Phenoxyethanol, Tromethamine, Chlorphenesin, Polyacrylate-13, Ethylhexylglycerin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isoceteth-10, Caprylyl Glycol, Isoceteth-25, Carbomer, Polyisobutene, Disodium Edta, Mentha Rotundifolia Leaf Extract, Citrus Aurantifolia Peel Extract, Cymbopogon Schoenanthus Extract, Polysorbate 20, Sorbitan Isostearate, Camellia Japonica Flower Extract, Fomes Officinalis Extract Mushroom Extract, 1,2-Hexanediol, Cinnamomum Zeylanicum Bark Extract, Uncaria Gambir Extract, Nelumbo Nucifera Flower Extract, Pelargonium Graveolens Extract, Sanguisorba Officinalis Root Extract, Bht, Pinus Palustris Leaf Extract, Pueraria Lobata Root Extract, Ulmus Davidiana Root Extract, Oenothera Biennis Flower Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin