# Medicube Zero Pore One-Day Cream for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Medicube](https://lovi.care/skincare/es/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin, this product effectively minimizes pores and moisturizes with niacinamide and hyaluronic acid, while salicylic acid offers mild exfoliation.
- Peptides and hyaluronic acid provide moderate benefits for your wrinkles and fine lines by supporting skin hydration and elasticity.
- The safety profile is excellent, with panthenol and allantoin providing soothing benefits and no risk of irritation for your normal skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/oily-acne-prone-skin): High

## Key ingredients

Panthenol, Bha, Glycerin, Niacinamide, Sodium Hyaluronate

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users with oily and combination skin appreciate this cream's lightweight, non-sticky texture that effectively balances moisture and controls sebum. Many report smoother skin texture and a reduction in the appearance of pores over time, though some find the "one-day" pore-shrinking claims to be exaggerated, suggesting it functions better as a daily moisturizer than a rapid treatment.

- Liked: Lightweight texture (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Oil control (sometimes noted)
- Liked: Skin smoothing (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Unsanitary packaging (sometimes noted)
- Liked: Pore maintenance (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes medicube Zero Pore One-Day Cream a great fit for mature skin?

This cream is a great fit because niacinamide and hyaluronic acid help smooth fine lines while keeping your skin plump and hydrated. Salicylic acid gently exfoliates, and panthenol soothes your skin without any risk of irritation.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for mature skin?

Niacinamide, hyaluronic acid, and peptides make this cream a great fit for mature skin by supporting hydration and smoothing fine lines. Salicylic acid also provides mild exfoliation while panthenol and allantoin soothe.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Panthenol do for mature skin?

Panthenol helps mature skin by increasing moisture and reducing water loss, which makes the skin feel softer and smoother. It also improves elasticity and reduces the appearance of wrinkles while soothing irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29577586/), [Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/)

### What does Bha do for mature skin?

BHA helps mature skin by smoothing out fine lines and increasing collagen to keep the face firm and elastic. Clinical studies show that regular use of ingredients like salicylic acid can improve skin thickness and reduce visible signs of aging.
Sources: [Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883290/), [Aesthetic Plastic Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/38926250/)

### Where does this cream go in a skincare routine for mature skin?

This treatment cream goes in the evening routine after your cleansing toner and before your moisturizer. Putting it in the evening keeps things simple and gives extra safety around sun exposure.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the treatment first and following with your moisturizer in the evening routine. Using a barrier-enhancing moisturizer helps reduce irritation and supports your skin while using retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment in the evening as part of your mature skin routine. Twice-daily application helps improve skin hydration, fine lines, and overall texture.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores, cause breakouts, or lead to purging on mature skin. Its ingredients help minimize pores while providing hydration and soothing benefits without adding heavy oils that trap debris.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this cream around the eyes or on my body?

You can use this cream on your body, but you should avoid applying it directly to the very thin skin around your eyes. The skin on your body is much thicker than the delicate eyelid area, making it better suited to handle active ingredients like salicylic acid without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin) — Superior fit — €19.75 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/es/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/mature-skin) — Superior fit — €92.00 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/es/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/mature-skin) — High fit — €60.90 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Bioré UV Perfect Milk SPF 50+ PA++++](https://lovi.care/skincare/es/p/biore/uv-face-milk-spf50-pa/for/mature-skin) — Superior fit — €25.88 at Amazon

## Where to buy

- Notino: €24.90 (https://www.notino.es/medicube/zero-pore-one-day-cream-crema-hidratante-ligera-para-cerrar-los-poros/p-16299752/)
Prices checked 17 Oct 2026.

## Ingredients

Water, Glycerin, Witch Hazel Extract, Panthenol, Allantoin, Melaleuca Alternifolia Tree Leaf Extract, Butylene Glycol, 12-Hexanediol, Hyaluronic Acid, Salicylic Acid, Niacinamide, Vitis Vinifera Fruit Extract Grape Fruit Extract, Camellia Sinensis Leaf Extract, Peptides, Sorbitan Olivate, Beta-Glucan
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-one-day-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-one-day-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-one-day-cream/for/mature-skin