# Medicube Zero Pore Cream 2.0 for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Medicube](https://lovi.care/skincare/es/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers moderate benefits for your acne, blemishes, and breakouts as niacinamide and centella asiatica extract help minimize pores and support skin health for your combination skin.
- Glycerin and panthenol provide humectant action and soothing effects, contributing to overall skin comfort.
- The formulation is safe for your skin due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Salicylic Acid, Sodium Hyaluronate, Willow Bark Extract, Oil Tree

## What the research says

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- Topical lycopene-enriched virgin olive oil provides effective pain relief similar to a placebo in patients with burning mouth syndrome, showing a strong placebo effect. ([Journal of Oral Rehabilitation, 2014](https://pubmed.ncbi.nlm.nih.gov/24612248/))

## What reviewers say

Based on a very large amount of data, users with combination and oily skin frequently praise this cream for its ability to balance sebum production while providing deep hydration without a sticky finish. Many report smoother skin texture and a fresh feeling. However, a significant number of reviewers note that visible reduction in pore size is subtle or non-existent despite the product's claims.

- Liked: Excellent hydration (mostly mentioned)
- Liked: Pleasant texture (often mentioned)
- Disliked: Ineffective on pores (often mentioned)
- Liked: Sebum control (sometimes noted)
- Liked: Skin smoothing (sometimes noted)
- Disliked: Strong scent (sometimes noted)
- Disliked: Heavy for some (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes medicube Zero Pore Cream 2.0 a great fit for acne-prone skin?

This cream is a great fit for your acne-prone skin because niacinamide and centella asiatica extract help minimize pores and support skin health. Glycerin and panthenol provide soothing comfort while keeping the formula safe and gentle.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for acne-prone skin?

This cream is a great fit for your acne-prone skin because niacinamide and centella asiatica extract help minimize pores and support skin health, while glycerin and panthenol provide soothing effects for skin comfort. The absence of harsh ingredients and the inclusion of calming components make the formulation safe for your skin.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Salicylic Acid do for acne-prone skin?

Salicylic acid helps clear acne-prone skin by reducing pimples and calming redness without causing many side effects. It works by dipping deep into pores to clear out blockages and control oil, making it a reliable choice for keeping skin smooth and clear.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Where does this cream go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, as niacinamide and centella asiatica extract help minimize pores and support skin health for acne-prone skin.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying it after your retinol product to help keep your skin calm and comfortable. The formula includes soothing ingredients that are unlikely to cause irritation when combined with active routines.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this cream?

You can use this treatment in the evening as part of your routine. It is gentle enough for regular use, helping to keep your skin calm and clear.

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to clog pores or cause breakouts on acne-prone skin because it avoids harsh ingredients and includes soothing components. Niacinamide and centella asiatica extract help minimize pores and support skin health, while glycerin and panthenol provide soothing comfort.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — €29.76 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €17.49 at Amazon

## Where to buy

- Amazon.de: €19.39 (https://www.amazon.de/dp/B0DKXDGMLZ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €36.90 (https://www.notino.es/medicube/zero-pore-cream-2-0-crema-facial-hidratante-para-minimizar-los-poros/p-16359270/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Niacinamide, Butylene Glycol, Cyclopentasiloxane, Dimethicone, Cyclohexasiloxane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Polysorbate 80, Squalane, Tocopheryl Acetate, Panthenol, Allantoin, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Portulaca Oleracea Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Scutellaria Baicalensis Root Extract, Polygonum Cuspidatum Root Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Coptis Japonica Root Extract, Adenosine, Ethylhexylglycerin, Caprylyl Glycol, 1,2-Hexanediol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin