# Medicube Zero Exosome Shot for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Medicube](https://lovi.care/skincare/es/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for normal skin, as niacinamide and gluconolactone work to even skin tone and smooth texture, while glycerin provides humectant action. However, the formula lacks targeted anti-inflammatory or barrier-repairing ingredients to effectively address your redness and irritation concerns.
- Panthenol is included for hydration, but the emollient support is not robust enough to fully counteract potential dryness for your normal skin with sensitivity.
- The product is safe for your normal skin with sensitivity, as it contains no harsh or prohibited ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/oily-acne-prone-skin): High

## Key ingredients

Lacto Exosome, Niacinamide, Betaine Salicylate, Adenosine, Hydrolyzed Sponge

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation. ([Biological & Pharmaceutical Bulletin, 2019](https://pubmed.ncbi.nlm.nih.gov/31257296/))
- Lactobacillus-derived exosome therapy combined with microneedling reduced acne severity, post-inflammatory hyperpigmentation, and atrophic scarring in three patients, with high satisfaction and minimal adverse effects. ([The Journal of Craniofacial Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/40257450/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- A nano-encapsulated spicule system delivering Wharton's Jelly MSC secretome enhanced transdermal penetration, promoted cell proliferation and collagen synthesis in vitro, and reduced wrinkles and pigmentation in clinical evaluation. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41155317/))
- Marine sponge spicules enhanced the skin delivery of human umbilical cord-derived mesenchymal stem cell exosomes by a factor of 5.87 and combined with them produced significant anti-photoaging effects in mice compared to exosomes alone. ([International Journal of Nanomedicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32368058/))
- The topical combination of Sph12-38 and sponge spicules achieved a 100% cure rate in rabbit ear acne treatment over two weeks compared to 40% for SHS alone, 0% for Sph12-38 alone, and 0% for the control group. ([Drug Delivery and Translational Research, 2025](https://pubmed.ncbi.nlm.nih.gov/39107673/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Users describe this ampoule as a potent texturizing treatment that delivers a glass skin finish by minimizing pores and smoothing roughness. While highly effective for many in tightening pores and boosting radiance, the sensation is polarizing, often described as a prickly or tingling feeling that can be intense for sensitive skin.

- Liked: Smoother texture (mostly mentioned)
- Disliked: Prickly sensation (mostly mentioned)
- Liked: Pore minimization (often mentioned)
- Liked: Radiance and glow (often mentioned)
- Liked: Enhanced absorption (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Unpleasant texture (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does MEDICUBE Zero Exosome Shot work for sensitive skin?

This treatment works moderately well for sensitive skin, helping to smooth texture and even tone while keeping your skin safe from harsh ingredients. However, it lacks targeted anti-inflammatory and stronger barrier-repairing ingredients to properly soothe redness and irritation. Treatments that fit sensitive skin better need calming plant extracts and soothing barrier supporters to comfortably calm redness and irritation.

### Which ingredients make this treatment a good fit for sensitive skin?

Niacinamide and gluconolactone help even skin tone and smooth texture, while glycerin and panthenol provide moisture. However, because this treatment lacks targeted anti-inflammatory and barrier-repairing ingredients to calm redness and irritation, sensitive skin needs a product with soothing and barrier-strengthening additions.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Lacto Exosome do for sensitive skin?

Lacto Exosome helps strengthen the skin barrier by boosting key proteins that keep dry or sensitive skin protected and hydrated. It is unlikely to irritate and may improve how well your skin holds onto moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40356846/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in your evening routine, placed after your soothing toner and before your moisturizer. Treatments with active ingredients are kept to the evening for simplicity and extra safety around sun exposure. Because this formula lacks targeted soothing or strong barrier-repairing ingredients for sensitive skin, a product of this type needs calming plant extracts, gentle hydrators, and skin-repairing ceramides to fully comfort redness and dryness.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol, but because it may cause dryness and irritation on sensitive skin, apply your retinol on a separate night or use gentle soothing ingredients and barrier-repairing support to keep skin calm and smooth.

### How often should I use it?

This treatment should be used once a week in your evening routine to help your sensitive skin adjust safely. Sensitive skin of this type needs products with soothing, anti-inflammatory, and strong barrier-repairing ingredients to calm redness and irritation while preventing dryness.

### Can it clog pores, cause breakouts or purging for sensitive skin?

MEDICUBE Zero Exosome Shot is unlikely to clog pores or cause breakouts for sensitive skin, though it may cause a prickly sensation or skin irritation for some people. A product of this type needs soothing and barrier-repairing ingredients to calm redness and protect sensitive skin effectively.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.80 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/es/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.13 at Amazon

## Where to buy

- Amazon.de: €15.60 (https://www.amazon.de/dp/B0D137TMRB?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-exosome-shot/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-exosome-shot/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-exosome-shot/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-exosome-shot/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-exosome-shot/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-exosome-shot/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-exosome-shot/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-exosome-shot/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-exosome-shot/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-exosome-shot/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/sensitive-skin