# Manyo Factory Bifida Biome Complex Ampoule for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Manyo Factory](https://lovi.care/skincare/es/brands/manyo-factory)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your oily skin due to the presence of niacinamide for seboregulation and multiple fermented ingredients for barrier repair, but lacks stronger oil-controlling agents for optimal results.
- The product provides excellent barrier resilience through Bifida Lysate Ferment and Bifida Ferment Filtrate, and general hydration from Sodium Hyaluronate and Glycerin, which are supportive for oily skin.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing components like Bifida Lysate Ferment and Niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Copper Tripeptide-1, Sodium Hyaluronate, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## Why other serums fit oily skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users widely praise this ampoule for its ability to strengthen the skin barrier and provide deep hydration without feeling heavy. Many report achieving a healthy, radiant glow and appreciate its lightweight, fast-absorbing texture, with some finding it soothing for redness and irritation. A small number of users experienced breakouts, and some felt the watery consistency was not moisturizing enough on its own or that the results did not justify the price.

- Liked: Strengthens barrier (mostly mentioned)
- Liked: Hydration and glow (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Soothing and calming (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Price vs. value (rarely noted)
- Disliked: Too watery (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Manyo Bifida Biome Complex Ampoule work for oily skin?

This ampoule offers moderate suitability for oily skin because niacinamide helps balance oil and fermented ingredients repair the barrier, but other products fit this skin type better. To work best for oily skin, a product of this type needs stronger oil-controlling ingredients, such as zinc PCA or ferulic acid, alongside balancing and soothing components.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this serum a good fit for oily skin?

Niacinamide helps balance oil, while fermented ingredients like Bifida Lysate Ferment repair your skin barrier. Sodium Hyaluronate and glycerin also provide lightweight moisture without clogging pores. Oily skin of this type needs stronger oil-controlling agents and ingredients like zinc PCA or ferulic acid for optimal results.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bifida Ferment Lysate do for oily skin?

Bifida Ferment Lysate helps strengthen the outer skin layer and calm redness, making it a good fit for oily skin that gets easily irritated. It also provides antioxidant support and helps keep skin defenses balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for oily skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Oily skin of this type needs stronger oil-controlling ingredients for optimal results.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying this product first in your evening routine, as it is very unlikely to cause irritation on oily skin. Following it with a moisturizer helps keep your skin calm and hydrated while you use retinol.

### How often should I use this serum?

This serum is used in the evening for simplicity and extra safety around sun exposure, though some versions can also be used in the morning or twice a day. Oily skin works with this product, but needs stronger oil-controlling ingredients like salicylic acid or clay for optimal results.

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to cause breakouts or clog pores on oily skin because it has a very safe formula free of harsh ingredients, though a small number of users have reported breakouts. It helps balance oil and soothe skin with niacinamide and fermented ingredients, but an oily skin type needs stronger oil-controlling ingredients for best results.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — €169.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — €29.76 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/oily-skin) — Superior fit — €17.49 at Amazon

## Where to buy

- Amazon.de: €18.50 (https://www.amazon.de/dp/B08DTTL17D?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Extract Ferment Filtrate, Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao Seed Extract, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- France: https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin