# La Roche-Posay Toleriane Dermallergo Night Cream for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [La Roche-Posay](https://lovi.care/skincare/es/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin, this product effectively addresses wrinkles and fine lines with Acetyl Dipeptide-1 Cetyl Ester to support collagen production and improve elasticity.
- Glycerin and squalane provide excellent humectant and emollient actions, enhancing your skin's barrier resilience and hydration.
- The formulation is safe for your skin, containing no harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/oily-acne-prone-skin): High

## Key ingredients

Thermal Water, Niacinamide, Squalane, Shea Butter, Allantoin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Cosmetic products containing 4-t-butylcyclohexanol demonstrated a faster and more pronounced soothing effect on capsaicin-induced burning compared to those containing acetyl dipeptide-1 cetyl ester in volunteers with sensitive skin. ([Journal of the European Academy of Dermatology and Venereology, 2016](https://pubmed.ncbi.nlm.nih.gov/26805418/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Users with ultra-sensitive, reactive, and allergy-prone skin frequently praise this night cream for its ability to instantly soothe redness and irritation without causing breakouts. While many appreciate the lightweight, gel-cream texture that absorbs quickly, those with extremely dry skin sometimes find it insufficiently moisturizing on its own, requiring an additional layer.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Safe for sensitive skin (often mentioned)
- Liked: Soothing and calming (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Hygienic packaging (sometimes noted)
- Disliked: Not hydrating enough (sometimes noted)
- Disliked: Adverse reactions (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes La Roche-Posay Toleriane Dermallergo Night Cream a great fit for mature skin?

This night cream is a great fit for mature skin because it uses Acetyl Dipeptide-1 Cetyl Ester to help smooth out wrinkles and fine lines by supporting firmness and elasticity. Glycerin and squalane team up to deeply hydrate and strengthen your skin barrier, keeping it soft and resilient.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Which ingredients make this cream a good fit for mature skin?

Acetyl Dipeptide-1 Cetyl Ester helps smooth wrinkles and fine lines by supporting collagen production, while glycerin and squalane deeply hydrate and strengthen your skin barrier. These ingredients work together to keep mature skin soft, plump, and resilient.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### What does Thermal Water do for mature skin?

Thermal water helps calm and soothe the skin while strengthening its natural barrier against daily environmental stress. It is unlikely to irritate mature skin and may help keep it comfortable and resilient.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2011](https://pubmed.ncbi.nlm.nih.gov/21175867/), [Journal of the European Academy of Dermatology and Venereology, 2022](https://pubmed.ncbi.nlm.nih.gov/34979589/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this cream go in a skincare routine for mature skin?

This cream fits into your routine as an evening moisturizing treatment, applied after your cleanser and toner. Using a nourishing moisturizer helps keep mature skin hydrated and supports a smooth, firm feel.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following it with this moisturizer to help keep your skin comfortable and hydrated. Using a barrier-supporting moisturizer alongside active treatments like retinol helps reduce dryness and supports overall skin tolerance.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your morning and evening routine to help smooth fine lines and keep your skin hydrated. Regular use is unlikely to cause irritation and supports your skin barrier over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin because it contains no harsh ingredients that could cause irritation and features hydrating and softening ingredients that keep skin balanced and calm. It does not contain ingredients that typically trigger purging.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream around the eyes or on my body?

This cream is safe for the body and around the eyes, though thinner areas like eyelids require gentle application. Its soothing ingredients and moisturizers help hydrate and protect delicate skin without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/es/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €59.99 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/mature-skin) — Superior fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €11.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Bioré UV Perfect Milk SPF 50+ PA++++](https://lovi.care/skincare/es/p/biore/uv-face-milk-spf50-pa/for/mature-skin) — Superior fit — €25.88 at Amazon

## Where to buy

- Amazon.de: €21.35 (https://www.amazon.de/dp/B09XJWJM44?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €26.00 (https://www.notino.es/la-roche-posay/toleriane-dermallergo-crema-hidratante-para-pieles-sensibles/p-16095544/)
- Lookfantastic: €28.18 (https://www.lookfantastic.es/p/la-roche-posay-toleriane-dermallergo-soothing-cream-for-sensitive-skin-40ml/12932546/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Propanediol, Butyrospermum Parkii Butter, Shea Butter, Pentylene Glycol, Squalane, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Pyridoxine Hcl, Polysorbate 20, Zea Mays Starch, Salvia Miltiorrhiza Root Extract, Allantoin, Glyceryl Acrylate, Acrylic Acid Copolymer, Sodium Hydroxide, Sphingomonas Extract Ferment, Hydroxyacetophenone, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Acetyl Dipeptide-1 Cetyl Ester, Xanthan Gum, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin
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- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin
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