# La Roche-Posay Hyalu B5 Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [La Roche-Posay](https://lovi.care/skincare/es/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your combination skin, as glycerin and panthenol provide hydration and enhance barrier resilience without exacerbating oiliness.
- While it offers general hydration benefits, the formula is not specialized for managing oily shine.
- The product is safe for your combination skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Vitamin B5, Madecassoside, Thermal Spring Water

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol following PicoWay laser treatment decreased transepidermal water loss, increased hydration and skin elasticity, reduced wrinkles and redness, and improved skin tone in 88 Chinese females compared to a standard care control group. ([Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))

## Why other moisturizers fit combination skin better

- A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28342238/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its intense hydration and ability to visibly plump the skin, leading to immediate improvements in bounce and a reduction in fine dehydration lines. While many users with sensitive skin find it gentle and soothing, a significant number dislike its strong floral fragrance and sticky finish.

- Liked: Intense hydration (mostly mentioned)
- Liked: Smoothes fine lines (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Gentle on sensitive skin (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Sticky texture (sometimes noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does La Roche-Posay Hyalu B5 Serum work for combination skin?

La Roche-Posay Hyalu B5 Serum works reasonably well for combination skin by providing moderate hydration and supporting the skin barrier without causing excess oiliness or irritation. However, a product of this type needs additional oil-controlling ingredients and specialized shine management to truly master both the dry and oily areas of combination skin.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for combination skin?

Glycerin and panthenol make this serum a good fit because they hydrate dry areas and help keep the skin barrier strong without adding extra oiliness. To suit combination skin even better, a moisturizing treatment also needs ingredients that help control oily shine.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Panthenol do for combination skin?

Panthenol helps balance combination skin by boosting moisture while keeping redness and irritation calm. It is unlikely to cause breakouts and may help repair the skin barrier safely.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29577586/)

### Where does this serum go in a skincare routine for combination skin?

Put this treatment in your evening routine after cleansing and before your moisturizer. It is unlikely to irritate your combination skin, but a product for this skin type also needs ingredients that help manage oily shine.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate your skin and then following with retinol. This helps keep your skin soft and smooth while reducing the dryness that retinol may cause. To truly fit combination skin best, a product of this type also needs ingredients that manage oily shine.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Daily application helps keep your skin soft and hydrated while supporting your natural moisture barrier.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts or clog pores for your combination skin since it has a very safe formula with no harsh or irritating ingredients. However, because it is not specialized for managing oily shine, combination skin generally needs lightweight hydrators and oil-balancing ingredients to keep the T-zone clear.

### Can I use this serum around the eyes or on my body?

This serum is safe to use around the eyes and on the body because it is gentle and well-tolerated. However, because combination skin needs extra help to manage oily shine, a product of this type needs specialized ingredients that balance oil while keeping skin hydrated.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/es/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/combination-skin) — High fit — €6.30 at Notino
- [SK-II LXP Ultimate Revival Essence](https://lovi.care/skincare/es/p/sk-ii/ultimate-revival-essence/for/combination-skin) — Average fit — €347.00 at Notino

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — €97.52 at Amazon

## Where to buy

- Amazon.de: €41.49 (https://www.amazon.de/dp/B0F1G1FLGX?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €41.40 (https://www.lookfantastic.es/p/la-roche-posay-hyalu-b5-suractivated-serum-30ml/17222049/)
- Notino: €43.50 (https://www.notino.es/la-roche-posay/hyalu-b5-suractivated-serum-serum-concentrado-antiarrugas/p-16328156/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Alcohol Denat, Propylene Glycol, Panthenol, Pentylene Glycol, Dimethicone, Peg-6 Caprylic Capric Glycerides, Ppg-6-Decyltetradeceth-30, Glyceryl Isostearate, Madecassoside, Sodium Hyaluronate, Ammonium Polyacryloyldimethyl Taurate, Disodium Edta, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Citric Acid, Xanthan Gum, Butylene Glycol, Tocopherol, Phenoxyethanol, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/hyalu-b5-serum/for/combination-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-roche-posay/hyalu-b5-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/hyalu-b5-serum/for/combination-skin