# Kiehl's Ultra Pure High-Potency Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Kiehl's](https://lovi.care/skincare/es/brands/kiehl-s)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this serum leverages glycerin and hyaluronic acid for excellent hydration, which can support the appearance of fine lines and wrinkles.
- The formula's humectant action is beneficial for maintaining skin moisture, though it does not offer specialized treatments for deeper wrinkles.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing hyaluronic acid.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Hyaluronic Acid, Glycerin

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this collection of minimalist serums is widely praised for its fast-absorbing, non-sticky textures and efficacy in targeting specific skin concerns like dryness, excess oil, and uneven texture. The Hyaluronic Acid version is lauded for immediate plumping, the Niacinamide serum is a favorite for controlling shine without irritation, and the Glycolic Acid variant is effective for smoothing skin, though it requires caution for sensitive types.

- Liked: Fast-absorbing texture (mostly mentioned)
- Liked: Effective oil control (often mentioned)
- Liked: Gentle minimalist formula (often mentioned)
- Liked: Immediate hydration (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Visible skin smoothing (sometimes noted)
- Disliked: Lack of dramatic results (sometimes noted)
- Disliked: Packaging concerns (rarely noted)
- Disliked: Potential irritation (rarely noted)
- Disliked: Texture preference (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Kiehl's Ultra Pure High-Potency Serum a great fit for mature skin?

This serum is a great fit for mature skin because it uses glycerin and hyaluronic acid to give your skin deep hydration, which helps smooth out the look of fine lines and wrinkles. It is very gentle and safe for daily use since it leaves out harsh ingredients that could cause irritation.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Glycerin and hyaluronic acid make this serum a great fit for mature skin by delivering deep hydration that helps smooth the look of fine lines and wrinkles. Because the formula lacks harsh ingredients and includes soothing components, it is gentle on the skin while maintaining daily moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine, applied after cleansing and before your moisturizer. It is unlikely to cause irritation and helps keep your skin hydrated while supporting the look of fine lines and wrinkles.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to give your skin a boost of moisture and help keep it calm. The formula is very safe and gentle, making it unlikely to cause irritation when layered with other active ingredients.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in your evening routine, and some of them may also be used in the morning or twice a day. It has a great safety profile for your mature skin with no risks of irritation.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause clogged pores, breakouts, or purging on mature skin. Its formula avoids harsh ingredients and relies on hydrating components that maintain moisture without heavy oils, keeping your skin safe from irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €169.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Shiseido Benefiance Wrinkle Smoothing Cream](https://lovi.care/skincare/es/p/shiseido/benefiance-wrinkle-smoothing-cream-enriched/for/mature-skin) — Superior fit — €57.95 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Hyaluronic Acid, Phenoxyethanol, Chlorphenesin, Tetrasodium Glutamate Diacetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/kiehl-s/ultra-pure-high-potency-serum/for/mature-skin