# iS Clinical Youth Eye Complex for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [iS Clinical](https://lovi.care/skincare/es/brands/is-clinical)
Category: [Eye care and eye patches](https://lovi.care/skincare/es/best/eye-creams)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best eye cares for mature skin.

## Why this fit

- Excellent suitability for your normal skin, as Acetyl Octapeptide-3 and Hyaluronic Acid work synergistically to plump and minimize fine lines, while Centella Asiatica Extract and Dipotassium Glycyrrhizate provide soothing benefits.
- The inclusion of Tripeptide-1 and Tripeptide-10 further enhances the peptide technology for targeting wrinkles and fine lines, complemented by Sodium Hyaluronate and Glycerin for humectant action.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of beneficial soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Acetyl Octapeptide-3, Centella Asiatica Extract, Retinyl Palmitate, Glycosaminoglycans

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate. ([Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical treatment with sphingolipids and glycosaminoglycans attenuated clinical worsening and reduced CADESI and PVAS scores compared to the untreated control group in house dust mite-allergic beagle dogs. ([BMC Veterinary Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32197613/))
- Glycosaminoglycans restored type I collagen synthesis, reduced matrix metalloproteinase-1 levels, upregulated tissue inhibitor of metalloproteinase-1, and attenuated apoptosis in tumor necrosis factor-alpha-stimulated human dermal fibroblasts by inhibiting extracellular signal-regulated kinase/activator protein-1 signaling. ([International Journal of Molecular Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/29436595/))
- Fraction 3 of glycosaminoglycans from Liparis tessellatus eggs showed 20.1% tyrosinase inhibition at 50mg/mL and effective skin regeneration activities at 200mg/mL against skin fibroblast CCD-986sk cell lines. ([International Journal of Biological Macromolecules, 2017](https://pubmed.ncbi.nlm.nih.gov/28917941/))

## What reviewers say

Users frequently praise this eye cream for its lightweight, fast-absorbing texture that layers well under makeup, effectively smoothing fine lines and reducing puffiness. A small number of users with sensitive eyes reported irritation, and some found the hydration insufficient for very dry or mature skin types, especially considering the price.

- Liked: Excellent under makeup (mostly mentioned)
- Liked: Lightweight hydration (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Reduces puffiness (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: Not moisturizing enough (rarely noted)

## Questions and answers

### What makes iS Clinical Youth Eye Complex one of the best fits for mature skin?

iS Clinical Youth Eye Complex is one of the best fits for mature skin because Acetyl Octapeptide-3 and sodium hyaluronate work together to plump and smooth fine lines, while Centella Asiatica extract helps keep the delicate eye area calm. It is unlikely to cause irritation and features a safe formula that uses peptides and soothing ingredients to target signs of aging.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this cream a good fit for mature skin?

This cream is an exceptional fit for mature skin because Acetyl Octapeptide-3 and Sodium Hyaluronate work together to plump and smooth out fine lines. Centella Asiatica Extract and Dipotassium Glycyrrhizate also help calm the skin, while Tripeptide-1 and Tripeptide-10 target wrinkles.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Acetyl Octapeptide-3 do for mature skin?

Acetyl Octapeptide-3 helps smooth mature skin and reduce the look of fine lines by relaxing the muscle movements that cause wrinkles. It is unlikely to irritate your face and works well to keep skin looking firm and youthful.
Sources: [International Journal of Cosmetic Science, 2002](https://pubmed.ncbi.nlm.nih.gov/18498523/), [Frontiers in Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/41924746/)

### Where does this cream go in a skincare routine for mature skin?

This eye cream goes in the treatment step of your evening routine, after cleansing and before moisturizing. Putting active treatments in the evening keeps things simple and protects your skin from extra sun exposure.

### Can I use this cream with retinol, and in what order?

You can use this eye cream alongside retinol by applying the retinol first, letting it absorb, and then following with this cream to help keep your eye area calm and smooth. This product is unlikely to irritate mature skin, and using a soothing formula can help your skin comfortably adjust to retinol.

### How often should I use this cream?

This eye cream is a great fit for mature skin, helping to smooth fine lines and keep the delicate eye area calm and soft. It is unlikely to cause irritation and can be used daily as part of your regular morning and evening routine.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This eye cream is unlikely to clog pores or cause breakouts on mature skin, as it has a safe profile with gentle, soothing ingredients that do not irritate. It helps keep the skin smooth and calm without heavy oils.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol and cetearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for mature skin

- [ELEMIS Pro-Collagen Eye Renewal](https://lovi.care/skincare/es/p/elemis/pro-collagen-eye-renewal/for/mature-skin) — Superior fit — €42.50 at Amazon
- [RoC Retinol Correxion Eye Cream](https://lovi.care/skincare/es/p/roc/retinol-correxion-line-smoothing-eye-cream/for/mature-skin) — High fit — €19.99 at Amazon
- [MARY & MAY Tranexamic Acid + Glutathione Eye Cream](https://lovi.care/skincare/es/p/mary-and-may/tranexamic-acid-glutathione-eye-cream/for/mature-skin) — Average fit — €13.17 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Shiseido Benefiance Wrinkle Smoothing Cream](https://lovi.care/skincare/es/p/shiseido/benefiance-wrinkle-smoothing-cream-enriched/for/mature-skin) — Superior fit — €57.95 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Hyaluronate, Caprylic Capric Triglyceride, Glycerin, Acetyl Octapeptide-3, Glyceryl Dilaurate, Pseudoalteromonas Extract Ferment, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide-10, Citrulline, Tripeptide-1, Lecithin, Silica Dimethyl Silylate, Dimethicone, Cetyl Alcohol, Cetearyl Alcohol, Ceteareth-20, Glyceryl Stearate, Peg-100 Stearate, Glycosaminoglycans, Urea, Glucose, Guanidine Hcl, Dipalmitoyl Hydroxyproline, Panthenol, Centella Asiatica Extract, Retinyl Palmitate, Tocopheryl Acetate, Ascorbyl Palmitate, Pantothenic Acid, Phytonadione, Dipotassium Glycyrrhizate, Butylene Glycol, Xanthan Gum, Carbomer, Triethanolamine, Pvp, Ethylhexyl Palmitate, Disodium Edta, 1,2-Hexanediol, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/youth-eye-complex/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/youth-eye-complex/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/youth-eye-complex/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/youth-eye-complex/for/mature-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/youth-eye-complex/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/youth-eye-complex/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/youth-eye-complex/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/is-clinical/youth-eye-complex/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/youth-eye-complex/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/youth-eye-complex/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/youth-eye-complex/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/youth-eye-complex/for/mature-skin