# iS Clinical Super Serum Advance+ for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [iS Clinical](https://lovi.care/skincare/es/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry skin.

## Why this fit

- Excellent for your dry skin, this formula features Ascorbic Acid and Arbutin to effectively brighten and even your skin tone while providing antioxidant benefits.
- Sodium Hyaluronate and Glycerin work synergistically to deliver exceptional hydration, addressing your dry or flaky skin concerns.
- The product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Sodium Hyaluronate, Arbutin, Tripeptide-1, Madecassic Acid

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))

## What reviewers say

This serum is highly regarded for its ability to brighten skin and reduce the appearance of scars and stretch marks. It is often described as a lightweight, fast-absorbing treatment suitable for acne-prone and aging skin, although its high price is a frequent concern among users.

- Liked: Brightens skin tone (mostly mentioned)
- Liked: Anti-aging effects (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces scars/marks (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Non-irritating (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Application sensation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Packaging/Value (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes iS Clinical Super Serum Advance+ one of the best fits for dry skin?

iS Clinical Super Serum Advance+ is an excellent fit for your dry skin because Sodium Hyaluronate and Glycerin work together to deliver exceptional hydration and fix flaky skin. It also features Ascorbic Acid and Arbutin to brighten and smooth your skin tone while providing antioxidant benefits.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for dry skin?

Sodium Hyaluronate and glycerin are the key ingredients that make this serum a great fit by delivering exceptional hydration to address flaky skin. Ascorbic acid and arbutin also help brighten and even out your skin tone while providing antioxidant benefits.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for dry skin?

Vitamin C helps dry skin by boosting moisture and keeping the surface smooth and soft. It may also improve skin hydration and support the outer protective barrier over time.
Sources: [Skin Research and Technology, 2008](https://pubmed.ncbi.nlm.nih.gov/19159387/), [Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for dry skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, keeping things simple and safe around sun exposure. It is unlikely to irritate dry skin and helps deliver deep hydration while brightening your skin tone.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum in your morning routine and your retinol at night. Using them at different times of day helps your skin absorb both ingredients safely without causing irritation.

### How often should I use this serum?

You can use this treatment in your evening routine, applying it after cleansing and before your moisturizer. It is unlikely to cause irritation and helps keep dry skin hydrated and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts on dry skin because it is free of heavy, pore-clogging ingredients and harsh substances that typically trigger irritation. It relies on lightweight hydrators to keep your skin smooth without feeling greasy.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/dry-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €8.85 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/dry-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/es/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Ascorbic Acid, Sodium Hyaluronate, Pentylene Glycol, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine Hcl, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/super-serum-advance/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/super-serum-advance/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/super-serum-advance/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/super-serum-advance/for/dry-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/super-serum-advance/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/super-serum-advance/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/dry-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/super-serum-advance/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/super-serum-advance/for/dry-skin