# iS Clinical Hydra-Cool Serum for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [iS Clinical](https://lovi.care/skincare/es/brands/is-clinical)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your dry and sensitive skin, this serum leverages sodium hyaluronate and pantothenic acid to provide excellent hydration and support barrier repair. The inclusion of menthol offers a refreshing, soothing sensation that complements the moisturizing benefits.
- Asiaticoside and mushroom extract further enhance the calming and hydrating properties, making it a good choice for managing dryness and flakiness.
- The formulation is safe for your skin, containing no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Asiaticoside, Madecassic Acid, Menthol, Pantothenic Acid

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Cooling skin temperature or applying topical menthol reduced histamine-induced itch intensity and flare diameters in healthy male volunteers. ([Neuroscience Letters, 1995](https://pubmed.ncbi.nlm.nih.gov/7624016/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Coadministration of 40% topical L-menthol with 10% trans-cinnamaldehyde reduced spontaneous pain intensity, neurogenic inflammation, primary and secondary mechanical hyperalgesia, and heat hyperalgesia, but not cold hyperalgesia, in 14 healthy volunteers. ([The Journal of Pain, 2016](https://pubmed.ncbi.nlm.nih.gov/27260636/))
- Topical application of menthol-based cooling gel decreased intramuscular temperature by 1.9 °C and increased cutaneous blood flow by 0.3 ml/min in healthy males compared to placebo gel. ([International Journal of Sports Physical Therapy, 2018](https://pubmed.ncbi.nlm.nih.gov/30038834/))
- Topical L-menthol and trans-cinnamaldehyde administered individually and in combination on the volar forearm of healthy volunteers induced distinct somatosensory and vasomotor effects, where L-menthol reduced the axon-reflex-flare and altered the mechanical hyperalgesia caused by trans-cinnamaldehyde. ([European Journal of Pain, 2014](https://pubmed.ncbi.nlm.nih.gov/24664788/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol following PicoWay laser treatment decreased transepidermal water loss, increased hydration and skin elasticity, reduced wrinkles and redness, and improved skin tone in 88 Chinese females compared to a standard care control group. ([Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/))
- Formulations containing 1.0% and 5.0% panthenol decreased transepidermal water loss after 30-day applications on healthy subjects compared to control and vehicle. ([Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21982351/))

## What reviewers say

This serum is widely praised as a "drink of water" for the skin, excelling at soothing irritation, redness, and sunburns while providing lightweight hydration. It is particularly favored by users with acne-prone and sensitive skin for its ability to calm inflammation without clogging pores, though some find it insufficient for extremely dry skin types.

- Liked: Soothing & Cooling (mostly mentioned)
- Liked: Lightweight Hydration (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Acne-Safe (sometimes noted)
- Liked: Versatile Use (sometimes noted)
- Disliked: Insufficient moisture (rarely noted)
- Disliked: Menthol sensitivity (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes iS Clinical Hydra-Cool Serum a great fit for dry sensitive skin?

iS Clinical Hydra-Cool Serum is a great fit because it uses sodium hyaluronate and pantothenic acid to deeply quench dryness and support your skin barrier. Asiaticoside and mushroom extract help calm your skin, while menthol adds a refreshing, soothing feel without harsh irritants.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Sodium hyaluronate and pantothenic acid make this serum a great fit by deeply hydrating dry skin and supporting the moisture barrier. Asiaticoside and madecassic acid further help calm irritation, while menthol provides a refreshing, soothing sensation that makes it gentle and comfortable for sensitive skin.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Hyaluronic Acid do for dry sensitive skin?

Hyaluronic acid is a great fit for dry, sensitive skin because it brings a large boost in hydration, making the skin feel soft and smooth while improving barrier function. It helps calm tightness and dryness, and is unlikely to cause irritation.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/)

### What does Asiaticoside do for dry sensitive skin?

Asiaticoside helps calm dry sensitive skin by reducing redness and soothing irritation while supporting the skin barrier. It is unlikely to cause irritation and works to keep the skin feeling comfortable and hydrated.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34764648/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to calm and hydrate your skin before layering retinol on top. This routine helps keep dry sensitive skin comfortable and supports barrier repair while using stronger active ingredients.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. Daily application of a moisturizing treatment helps improve skin moisture and manage dryness and flakiness.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is a great fit for your dry sensitive skin because it uses sodium hyaluronate and pantothenic acid to deeply hydrate without heavy, pore-clogging oils. The formula is safe and free of harsh ingredients, so it is unlikely to cause breakouts or purging.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum around the eyes and on your body because its gentle formula is safe and well-tolerated for sensitive areas. The ingredients help boost moisture and calm dry patches while keeping the skin feeling soft and comfortable.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [Kiehl's Midnight Recovery Concentrate](https://lovi.care/skincare/es/p/kiehl-s/midnight-recovery-concentrate/for/dry-sensitive-skin) — High fit — €54.78 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €8.85 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/dry-sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/es/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €16.99 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Hyaluronate, Pantothenic Acid, Pentylene Glycol, Menthol, Phenoxyethanol, Asiaticoside, Polyporus Umbellatus Extract Mushroom Extract, Asiatic Acid, Madecassic Acid, Blue 1 Ci 42090
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin