# IOPE Pro Peeling Enzyme Wash for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [IOPE](https://lovi.care/skincare/es/brands/iope)
Category: [Exfoliants](https://lovi.care/skincare/es/best/exfoliators)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few products fit it even better.

## Why this fit

- Offers excellent exfoliation for your oily skin, as papain and protease work to smooth texture and regulate desquamation with lemon fruit extract and saccharum officinarum extract.
- Lipase further aids in enzymatic cleansing, addressing oily shine effectively.
- The formula is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin): High

## Key ingredients

Papain, Squalane, Acetyl Glucosamine, Betaine, Vaccinium Myrtillus Fruit Extract

## What the research says

- Combined sequential treatment with microneedling and 35% glycolic acid peels caused a significant improvement in superficial and moderately deep acne scars, skin texture, and postacne pigmentation in thirty patients compared to thirty patients receiving microneedling alone. ([Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151943/))
- A combination of dermapen and glycolic acid peel significantly decreased acne scar grades and resulted in higher patient satisfaction compared to either monotherapy in 30 patients. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30548170/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- Enzymatic hydrolysis of codfish skin using SM9913 extracellular protease yielded over 66% of collagen oligopeptide-rich hydrolysates with high bioactivity, including moisture-retention, antioxidant activity, and promotion of human dermal fibroblast cell viability, while proving to be nontoxic and nonirritating. ([Scientific Reports, 2017](https://pubmed.ncbi.nlm.nih.gov/29146927/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Mixed surfactant systems of sodium dodecyl sulfate and dimethyl dodecyl amido betaine significantly reduce acute skin irritation potential in human volunteers compared with the individual surfactants, demonstrating that irritation potential cannot be predicted by simple summation. ([Food and Chemical Toxicology, 1998](https://pubmed.ncbi.nlm.nih.gov/9609395/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))

## What reviewers say

Based on limited data, users find this enzyme wash effectively exfoliates and smooths skin, leaving it feeling soft and clean without dryness, making it suitable for sensitive skin. However, the product is considered expensive for the quantity provided, and the powder format can lead to clumping and dispensing difficulties.

- Liked: Improved skin texture (mostly mentioned)
- Liked: Gentle exfoliation (often mentioned)
- Liked: Non-stripping cleanse (often mentioned)
- Disliked: Expensive for amount (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Effective deep clean (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your enzyme powder cleanser as part of your AM or PM weekly routine. Start using it 1x per week and increase to daily use if your skin tolerates it well.
- Apply this enzyme powder cleanser in your routine after the regular cleanser and before the hydrating toner, serum, and moisturizer.
- Gently mix the enzyme powder cleanser with water in your hands to create a lather. Massage it softly over your face without rubbing .
- Apply the enzyme powder cleanser to clean, slightly damp skin for the best results .
- Avoid the sensitive eye area and do a patch test before your first use to ensure your skin is happy.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes IOPE Pro Peeling Enzyme Wash a great fit for oily skin?

IOPE Pro Peeling Enzyme Wash is a great fit because it offers excellent exfoliation with papain and protease to smooth texture and reduce oily shine. The formula is also very safe and is unlikely to cause irritation on your skin.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/), [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### Which ingredients make this cleanser a good fit for oily skin?

Papain, protease, and lipase make this cleanser a great fit because they smooth texture and help control oily shine. Lemon fruit extract and saccharum officinarum extract also support this fit by helping clear away buildup safely.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### What does Papain do for oily skin?

Papain helps clear oily skin by gently lifting away dead cells and surface buildup to leave your face feeling smooth. This ingredient helps reduce clogged pores and flakes, though it may occasionally cause mild irritation if your skin barrier is sensitive.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Archives of Dermatological Research, 2001](https://pubmed.ncbi.nlm.nih.gov/11820726/)

### What does Squalane do for oily skin?

Squalane helps keep oily skin soft and smooth without feeling heavy, though oxidized forms may sometimes trigger irritation. To work well for oily skin, this type of product needs lightweight, non-clogging ingredients that balance moisture without adding excess grease.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### Where does this cleanser go in a skincare routine for oily skin?

This enzyme powder cleanser goes into your weekly routine as an exfoliating step, used once a week to help smooth texture and reduce oily shine. People who tolerate it well and see good results can carefully use it more often. The formula is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients.

### Can I use it with retinol, and in what order?

You can use this enzyme wash in your routine alongside retinol, but apply them at different times to keep your skin calm. Use this cleanser as part of your weekly routine, and save your retinol for your evening treatment steps on other days.

### How often should I use this cleanser?

Use this enzyme powder cleanser once a week as part of your weekly routine. People who tolerate it well and see good results can carefully use it more often.

### Can it clog pores, cause breakouts or purging for oily skin?

It is unlikely to clog pores or cause breakouts on oily skin, as it gently sweeps away dead skin cells to keep pores clear and calm. The formula is safe for your skin with no harsh ingredients.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/), [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### Is this cleanser fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (ethanol).

## Alternatives for oily skin

- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/es/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/oily-skin) — High fit — €17.32 at Amazon
- [Fancl Deep Clear Washing Powder](https://lovi.care/skincare/es/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit — €19.99 at Amazon
- [VT Cica Mild Powder Wash](https://lovi.care/skincare/es/p/vt/cica-mild-powder-wash/for/oily-skin) — High fit — €5.60 at Notino

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/oily-skin) — Superior fit — €17.49 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Microcrystalline Cellulose, Sodium Cocoyl Glycinate, Sodium Lauroyl Glutamate, Silica, Papain, Protease, Lipase, Lemon Fruit Extract, Saccharum Officinarum Extract, Sugar Maple Extract, Vaccinium Myrtillus Fruit Extract, Citrus Aurantium Dulcis Fruit Extract, Betaine, Squalane, Acetyl Glucosamine, Allantoin, Chitosan, Alpha-Glucan Oligosaccharide, Ethyl Cellulose, Ethanol, Xanthan Gum, Water, Butylene Glycol, Polycaprolactone, Peg-75, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- France: https://lovi.care/skincare/fr/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/oily-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pro-peeling-enzyme-wash/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pro-peeling-enzyme-wash/for/oily-skin