# IOPE Pro Peeling Enzyme Wash for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [IOPE](https://lovi.care/skincare/es/brands/iope)
Category: [Exfoliants](https://lovi.care/skincare/es/best/exfoliators)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few products fit it even better.

## Why this fit

- Offers excellent exfoliation for your combination skin, as papain and protease enzymes effectively smooth texture and regulate desquamation. Betaine and squalane further support hydration and skin barrier function, enhancing overall skin health.
- The presence of lemon fruit extract and saccharum officinarum extract provides additional gentle exfoliation and brightening benefits, complementing the primary enzymatic action.
- This formulation is safe for your skin, with no reported risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin): High

## Key ingredients

Papain, Squalane, Acetyl Glucosamine, Betaine, Vaccinium Myrtillus Fruit Extract

## What the research says

- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- L-ascorbic acid and betaine-based therapeutic deep eutectic system significantly enhanced transdermal delivery through porcine skin compared to ascorbic acid alone or physical mixture, and reduced aging markers while inducing an even skin tone in humans. ([Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38794349/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Combined sequential treatment with microneedling and 35% glycolic acid peels caused a significant improvement in superficial and moderately deep acne scars, skin texture, and postacne pigmentation in thirty patients compared to thirty patients receiving microneedling alone. ([Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151943/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- Mixed surfactant systems of sodium dodecyl sulfate and dimethyl dodecyl amido betaine significantly reduce acute skin irritation potential in human volunteers compared with the individual surfactants, demonstrating that irritation potential cannot be predicted by simple summation. ([Food and Chemical Toxicology, 1998](https://pubmed.ncbi.nlm.nih.gov/9609395/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))

## What reviewers say

Based on limited data, users find this enzyme wash effectively exfoliates and smooths skin, leaving it feeling soft and clean without dryness, making it suitable for sensitive skin. However, the product is considered expensive for the quantity provided, and the powder format can lead to clumping and dispensing difficulties.

- Liked: Improved skin texture (mostly mentioned)
- Liked: Gentle exfoliation (often mentioned)
- Liked: Non-stripping cleanse (often mentioned)
- Disliked: Expensive for amount (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Effective deep clean (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Could be used as part of your PM routine once a week. Start 3x/week and build up to daily use if your skin tolerates it well.
- Apply the enzyme powder cleanser after your regular cleanser and toner, but before your moisturizer.
- Pour a small amount into wet hands and rub together to create a creamy foam, then massage gently onto the face.
- Apply the enzyme powder cleanser on slightly damp skin to help activate the gentle exfoliating enzymes.
- Avoid the eye area and do a patch test before your first use to ensure your skin feels comfortable.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes IOPE Pro Peeling Enzyme Wash a great fit for combination skin?

IOPE Pro Peeling Enzyme Wash is a great fit because its papain and protease enzymes gently smooth your texture while betaine and squalane keep your skin hydrated. It also includes fruit extracts that brighten your look without any harsh ingredients that might cause irritation.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/)

### Which ingredients make this cleanser a good fit for combination skin?

Papain and protease enzymes make this cleanser a great fit by effectively smoothing texture and regulating shedding for your combination skin. Betaine and squalane further support hydration and your skin barrier, while lemon fruit and sugar cane extracts provide gentle exfoliation and brightening benefits.

### What does Papain do for combination skin?

Papain gently exfoliates the skin by breaking down dead surface proteins, which helps keep oily and dry areas balanced and smooth. It is unlikely to cause severe irritation when used properly, though mild tingling may occur.
Sources: [International Journal of Cosmetic Science, 2022](https://pubmed.ncbi.nlm.nih.gov/35892222/)

### What does Squalane do for combination skin?

Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.
Sources: [Skin Health and Disease, 2024](https://pubmed.ncbi.nlm.nih.gov/39355739/), [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/)

### Where does this cleanser go in a skincare routine for combination skin?

This enzyme powder cleanser goes into your weekly routine for combination skin. It is used once a week as an exfoliating step after your makeup remover and cleanser, and before your cleansing mask, hydrating toner, treatment, and moisturizer.

### Can I use this cleanser with retinol, and in what order?

You can use this enzyme powder cleanser alongside retinol by keeping them on separate days or times, since this formula offers strong exfoliation. Using both at the same time may make your skin sensitive, so alternate them or use the cleanser weekly to keep your skin smooth and calm.

### How often should I use this cleanser?

This enzyme powder is a great fit for your combination skin and should be used once a week to start. You can carefully use it more often if your skin tolerates it well and you see good results.

### Can this cleanser clog pores, cause breakouts or purging for combination skin?

IOPE Pro Peeling Enzyme Wash is unlikely to clog pores or cause breakouts for combination skin because it is formulated with safe, non-irritating ingredients that effectively smooth texture and regulate shedding. The inclusion of betaine and squalane further supports your skin barrier without heavy residues.
Sources: [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/)

### Is this cleanser fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (ethanol).

## Alternatives for combination skin

- [Fancl Deep Clear Washing Powder](https://lovi.care/skincare/es/p/fancl/deep-clear-washing-powder/for/combination-skin) — High fit — €19.99 at Amazon
- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/es/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/combination-skin) — Average fit — €17.32 at Amazon
- [VT Cica Mild Powder Wash](https://lovi.care/skincare/es/p/vt/cica-mild-powder-wash/for/combination-skin) — High fit — €5.60 at Notino

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — €97.52 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Microcrystalline Cellulose, Sodium Cocoyl Glycinate, Sodium Lauroyl Glutamate, Silica, Papain, Protease, Lipase, Lemon Fruit Extract, Saccharum Officinarum Extract, Sugar Maple Extract, Vaccinium Myrtillus Fruit Extract, Citrus Aurantium Dulcis Fruit Extract, Betaine, Squalane, Acetyl Glucosamine, Allantoin, Chitosan, Alpha-Glucan Oligosaccharide, Ethyl Cellulose, Ethanol, Xanthan Gum, Water, Butylene Glycol, Polycaprolactone, Peg-75, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- France: https://lovi.care/skincare/fr/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/combination-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pro-peeling-enzyme-wash/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pro-peeling-enzyme-wash/for/combination-skin