# DRMTLGY Needle-less Serum for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [DRMTLGY](https://lovi.care/skincare/es/brands/drmtlgy)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry skin.

## Why this fit

- Excellent suitability for your dry skin is provided by Glycerin and Sodium Hyaluronate for humectant action and Ceramides, Phytosphingosine, and Cholesterol for barrier repair, addressing your dry or flaky skin concerns.
- The serum offers excellent plumping and firming benefits due to the moderate concentrations of Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, and Palmitoyl Tripeptide-5, further enhancing your skin's texture.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the presence of soothing components like Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Niacinamide, Palmitoyl Tripeptide-1, Ceramide Eop, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of an emulsion containing a complete mixture of ceramides III, IIIB, VI, phytosphingosine, cholesterol, and linoleic acid significantly accelerated barrier recovery after SLS damage and improved skin hydration after acetone treatment in human volunteers compared to an emulsion containing only two types of ceramides. ([Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

While many report softer fine lines and improved texture, critical reviews often note that the "needle-less" claim is marketing hyperbole, as the product functions more as a high-quality hydrating peptide serum than a true alternative to injectables.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Excellent texture (often mentioned)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Softens fine lines (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Price point (rarely noted)
- Disliked: Scent and packaging (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes DRMTLGY Needle-less Serum one of the best fits for dry skin?

This serum is one of the best fits because glycerin and sodium hyaluronate draw in moisture while ceramides, phytosphingosine, and cholesterol help repair the skin barrier to address dry or flaky skin. It also helps plump and firm the skin and has a very safe profile with soothing panthenol that is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin and Sodium Hyaluronate draw moisture into dry skin, while ceramides, phytosphingosine, and cholesterol help repair the skin barrier. Peptides like Palmitoyl Tripeptide-1 also smooth and firm the skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Where does it go in a skincare routine for dry skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. Putting it in the evening keeps things simple and adds extra safety around sun exposure, though it is unlikely to cause irritation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help keep your dry skin calm and comfortable while the retinol works. It is unlikely to cause irritation when used this way because the formula includes soothing ingredients and lacks harsh components.

### How often should I use it?

This serum fits into your evening routine as a treatment step. It helps keep dry or flaky skin feeling soft and smooth while improving firmness without irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on dry skin. It has a very safe formula with soothing ingredients that avoid irritation.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/dry-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €8.85 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/dry-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/es/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

- Amazon.de: €59.31 (https://www.amazon.de/dp/B0CJK22LNX?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum Extract, Bambusa Vulgaris Stem Extract Leaf, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide Eop, Glucosamine Hcl, Glycosaminoglycans, Ceramide Np, Palmitoyl Tripeptide-5, Ceramide Ap, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate Prolinate, Panthenol, Phenoxyethanol, Ethylhexylglycerin, Polysorbate 20, Disodium Edta, Butylene Glycol, Carbomer, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drmtlgy/needle-less-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/drmtlgy/needle-less-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/drmtlgy/needle-less-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/drmtlgy/needle-less-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/drmtlgy/needle-less-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/drmtlgy/needle-less-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/drmtlgy/needle-less-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/dry-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/drmtlgy/needle-less-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/drmtlgy/needle-less-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/drmtlgy/needle-less-serum/for/dry-skin