# Derma E Anti-Wrinkle Renewal Cream for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Derma E](https://lovi.care/skincare/es/brands/derma-e)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and anti-aging benefits for your normal skin, as glycerin provides hydration and retinol smooths texture, while Bakuchiol supports collagen stimulation.
- The inclusion of Panthenol Vitamin B5 and Allantoin offers supportive benefits for your redness and irritation, though additional humectants would enhance overall hydration.
- The product is safe for your sensitive skin, featuring soothing ingredients like Panthenol Vitamin B5 and Allantoin and lacking harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Bakuchiol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Carthamus Tinctorius Seed Oil

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Safflower oil body-human epidermal growth factor microgel emulsions mixed with xanthan gum enhance transdermal absorption, regulate inflammation, accelerate angiogenesis, and promote re-epithelialization and remodeling in full-layer skin wounds in rats. ([International Journal of Biological Macromolecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36126813/))

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Derma-E Anti-Wrinkle Renewal Cream work for sensitive skin?

This cream works for sensitive skin, though other products fit it better because they offer stronger hydration and barrier repair without overwhelming your skin. It helps calm redness and smooth texture using soothing ingredients and retinol, while a product of this type needs extra hydrators like glycerin or hyaluronic acid and soothing plant extracts for the best results.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for sensitive skin?

Panthenol Vitamin B5 and Allantoin make this cream a good fit for sensitive skin by helping calm redness and irritation. Panthenol acts as a moisturizer that improves hydration and helps soothe irritated skin.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Retinol do for sensitive skin?

Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### What does Bakuchiol do for sensitive skin?

Bakuchiol helps improve barrier function, reduces redness and sensitivity, and softens fine lines in sensitive skin with a very low likelihood of scaling and stinging.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/)

### Where does this cream go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your toner and before your moisturizer. Putting it in the evening keeps it simple and provides extra safety around sun exposure.

### Can I use this cream with vitamin C, and in what order?

You can use this cream with vitamin C by applying vitamin C in the morning and this cream at night, as using active ingredients at different times helps prevent irritation on sensitive skin. To make a product of this type fit sensitive skin better, it needs extra soothing humectants and barrier-restoring ingredients.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this cream?

You can use this cream in the evening, as Lovi routines put treatments in the PM for simplicity and safety around sun exposure. Applying it daily helps improve skin moisture and texture, though a product of this type for sensitive skin needs extra hydrating ingredients to feel fully comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to clog pores or cause breakouts for your sensitive skin, as it features soothing ingredients like Panthenol and Allantoin and lacks harsh or prohibited substances. Because it contains retinol, it may occasionally cause mild purging or irritation as it smooths your texture. To work best for sensitive skin, this type of product needs additional hydrating ingredients to keep skin comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this cream around the eyes or on my body?

You can use this cream on your body, but the skin around your eyes is much thinner and may be more easily irritated by the active ingredients. A product of this type needs extra soothing ingredients and deep hydrators to safely care for thin or delicate areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/es/p/belif/the-true-cream-aqua-bomb/for/sensitive-skin) — High fit — €35.00 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/sensitive-skin) — High fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/sensitive-skin) — High fit — €11.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.80 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/es/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.13 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Carthamus Tinctorius Seed Oil, Stearic Acid, Glycerin, Glyceryl Stearate Se, Cetyl Alcohol, Microcrystalline Cellulose, Cellulose Gum, Persea Gratissima Oil Avocado Oil, Sesamum Indicum Seed Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Bakuchiol, Retinol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Allantoin, Phenoxyethanol, Ethylhexylglycerin, Oils
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin