# Derma E Anti-Wrinkle Renewal Cream for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Derma E](https://lovi.care/skincare/es/brands/derma-e)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and anti-aging benefits for your dry skin, as glycerin and panthenol vitamin B5 provide hydration while retinol smooths texture.
- The inclusion of bakuchiol and vitamin E offers additional antioxidant support, though more potent emollient and occlusive ingredients could enhance results for your dry or flaky skin.
- The product is generally safe for your dry skin, with a low risk of irritation from retinol in moderate concentrations.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Bakuchiol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Carthamus Tinctorius Seed Oil

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Safflower oil body-human epidermal growth factor microgel emulsions mixed with xanthan gum enhance transdermal absorption, regulate inflammation, accelerate angiogenesis, and promote re-epithelialization and remodeling in full-layer skin wounds in rats. ([International Journal of Biological Macromolecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36126813/))

## Why other moisturizers fit dry skin better

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss. ([Acta Biochimica Polonica, 2012](https://pubmed.ncbi.nlm.nih.gov/22428137/))

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Derma-E Anti-Wrinkle Renewal Cream work for dry skin?

This cream works moderately well for dry skin, as glycerin and panthenol vitamin B5 add hydration while retinol helps smooth texture. It is generally safe with a low risk of irritation, but a product of this type needs richer heavy oils and sealing ingredients to truly lock in moisture and soften dry or flaky skin.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for dry skin?

Glycerin and panthenol vitamin B5 help make this cream a good fit by providing hydration for your dry skin. Retinol also smooths texture while vitamin E and bakuchiol offer additional antioxidant support.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Retinol do for dry skin?

Retinol is a poor fit for dry skin because it frequently causes scaling, stinging, and dryness. To care for dry skin properly, a product needs gentle, hydrating ingredients like ceramides, glycerin, and hyaluronic acid to lock in moisture and keep the skin barrier calm and smooth.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### What does Bakuchiol do for dry skin?

Bakuchiol helps soothe sensitive dry skin while keeping it soft and smooth. It improves skin moisture content and barrier function while reducing redness and irritation.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346506/)

### Where does it go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps it simple and lowers the risk of sun sensitivity. A consistent routine featuring hydrating ingredients helps improve overall dry skin.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this cream with vitamin C, and in what order?

You can use this cream with vitamin C by applying your vitamin C product in the morning and saving this cream for your evening routine. Using them at different times of day helps avoid mixing strong active ingredients that may irritate dry skin. To get better results for dry skin, this type of product needs heavier nourishing ingredients to lock in moisture.

### How often should I use it?

You can use this treatment in your evening routine, applying it after cleansing and before moisturizing. The retinol in moderate concentrations is generally safe for dry skin with a low risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for dry skin?

This cream is unlikely to clog pores or cause breakouts on dry skin, though the retinol in it may cause mild initial purging or flaking as your skin adjusts. A product for this skin needs richer moisturizing and sealing ingredients to deeply soften and lock in hydration.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use it around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, but dry skin needs richer oils and butters to stay soft and smooth.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/es/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/dry-skin) — High fit — €92.00 at Amazon
- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-tox-cream/for/dry-skin) — High fit — €19.75 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/es/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/dry-skin) — High fit — €60.90 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €8.85 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/dry-skin) — Superior fit — €34.00 at Amazon
- SPF: [Purito Daily Soft Touch Sunscreen](https://lovi.care/skincare/es/p/purito/daily-soft-touch-sunscreen/for/dry-skin) — Superior fit — €12.98 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Carthamus Tinctorius Seed Oil, Stearic Acid, Glycerin, Glyceryl Stearate Se, Cetyl Alcohol, Microcrystalline Cellulose, Cellulose Gum, Persea Gratissima Oil Avocado Oil, Sesamum Indicum Seed Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Bakuchiol, Retinol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Allantoin, Phenoxyethanol, Ethylhexylglycerin, Oils
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- France: https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin