# Clinique Dramatically Different Moisturizing Lotion+ for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Clinique](https://lovi.care/skincare/es/brands/clinique)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration for your normal skin, as glycerin and sodium hyaluronate provide humectant action, while urea offers mild exfoliation and hydration.
- While beneficial for general skin health, the formula lacks specialized ingredients like niacinamide or centella asiatica to directly target your redness and irritation.
- The product is safe for your sensitive skin, with no harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/oily-skin): Caution
- [Dry skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/combination-skin): Caution
- [Sensitive skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/oily-acne-prone-skin): Caution

## Key ingredients

Glycerin, Sodium Hyaluronate, Sesamum Indicum Oil, Cucumis Sativus Fruit Extract, Hordeum Vulgare Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Sesame-derived cosmetic ingredients are safe and not skin irritants, sensitizers, teratogens, or carcinogens at exposures resulting from cosmetic use. ([International Journal of Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21772026/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of sesame oil combined with standard care significantly reduced infusion-related phlebitis in adults compared to a control condition, with a risk ratio of 0.54. ([Complementary Therapies in Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39743002/))
- Sesamol loaded silver nanoparticles gel showed a twofold increase in skin permeation and higher antioxidant activity compared to conventional formulations, demonstrating potential for topical wound healing delivery. ([Current Pharmaceutical Design, 2024](https://pubmed.ncbi.nlm.nih.gov/39192646/))
- Treatment with moderately ozonated sesame oil accelerates cutaneous wound closure and enhances cell response, angiogenesis, and VEGF and cyclin D1 expression in SKH1 mice compared to oil with lower or higher peroxide values and controls. ([Wound Repair and Regeneration, 2011](https://pubmed.ncbi.nlm.nih.gov/21134039/))
- Transgenic cucumber expressing poly-γ-glutamic acid synthesis genes increased water content by 6-14%, reduced water loss by 11-12%, decreased facial wrinkles and roughness by 19.58% and 24.97%, decreased skin melanin by 5.27%, and improved facial elasticity in human skin and zebrafish compared to controls. ([International Journal of Biological Macromolecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38336313/))
- Copper Oxide nanoparticles synthesized using cucumber extract exhibited antibacterial, antifungal, UV protection, and reactive-oxygen species inhibition properties with low cellular toxicity and skin-rejuvenating effects when incorporated into skin cream. ([Endocrine, Metabolic & Immune Disorders Drug Targets, 2021](https://pubmed.ncbi.nlm.nih.gov/32628604/))
- Topical treatment with Holothuria parva extract gel showed significant wound contraction compared to the negative control in full-thickness wounded rats. ([The International Journal of Lower Extremity Wounds, 2024](https://pubmed.ncbi.nlm.nih.gov/34791922/))

## Why other moisturizers fit sensitive skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A dexpanthenol-containing cream accelerated skin barrier repair, increased stratum corneum hydration, reduced skin roughness, and decreased skin redness compared to vehicle and untreated controls in sodium lauryl sulphate-irritated skin. ([The Journal of Dermatological Treatment, 2002](https://pubmed.ncbi.nlm.nih.gov/19753737/))

## What reviewers say

Based on a very large amount of data, this lotion is a highly regarded staple for dry and combination skin, frequently praised for restoring the moisture barrier and leaving a soft, non-greasy finish. Most users report improved hydration and a healthy glow. A moderate number of users experienced breakouts or found the texture too heavy for oily areas.

- Liked: Effective hydration (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Gentle/fragrance-free (sometimes noted)
- Liked: Makeup compatibility (sometimes noted)
- Disliked: Caused breakouts (sometimes noted)
- Disliked: Formula change (rarely noted)
- Disliked: Greasy residue (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Clinique Dramatically Different Moisturizing Lotion work for sensitive skin?

Clinique Dramatically Different Moisturizing Lotion+ is an average fit for sensitive skin, offering gentle hydration while lacking specialized calming ingredients to directly target redness. To better suit sensitive skin, a moisturizer of this type needs soothing ingredients like fermented centella asiatica, cica ceramide, and nourishing oils to calm irritation and strengthen the skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21772026/)

### Which ingredients make this moisturizer a good fit for sensitive skin?

Glycerin, sodium hyaluronate, and urea make this moisturizer a good fit by providing hydration and mild exfoliation while being safe for your skin. However, to truly fit sensitive skin, a moisturizer of this type needs soothing ingredients like centella asiatica or cica ceramide to calm redness and irritation.

### What does Glycerin do for sensitive skin?

Glycerin helps keep sensitive skin soft and deeply hydrated while supporting the skin barrier. It is unlikely to cause irritation and may protect against dryness and roughness.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Acta Dermato-venereologica, 1999](https://pubmed.ncbi.nlm.nih.gov/10598752/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does it go in a skincare routine for sensitive skin?

This moisturizer goes last in your evening routine, and just before your sunscreen in the morning. It is safe for sensitive skin, but to properly care for redness and irritation, this skin type needs specialized ingredients like niacinamide or centella asiatica.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this moisturizer with retinol, and in what order?

You can use this moisturizer with retinol by applying it after your retinol treatment to help keep your skin soft and comfortable. This type of product needs soothing and calming ingredients like niacinamide or centella asiatica to better care for sensitive skin and reduce redness.

### How often should I use it?

You can use this moisturizer daily in your morning and evening routines. Regular application helps keep sensitive skin comfortable and hydrated.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/)

### Can this moisturizer clog pores, cause breakouts or purging for sensitive skin?

This moisturizer may cause breakouts for some people with sensitive skin, as moderate reviewer complaints report this issue. Mineral oil and petrolatum are included in the formula, which can feel heavy or trap oil on certain skin types.

### Can I use it around the eyes or on my body?

This moisturizer is safe to use around the eyes and on the body, as it has a gentle formula that is unlikely to cause irritation on sensitive areas. Skin on the eyelids is among the thinnest on the body, meaning gentle and well-tolerated hydration is especially important there.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this moisturizer fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/es/p/belif/the-true-cream-aqua-bomb/for/sensitive-skin) — High fit — €35.00 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/sensitive-skin) — High fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/sensitive-skin) — High fit — €11.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.80 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/es/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €23.99 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/es/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.13 at Amazon

## Where to buy

- Amazon.de: €20.97 (https://www.amazon.de/dp/B00CVZ3NJ2?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €18.90 (https://www.notino.es/clinique/dramatically-different-moisturizing-lotion-spf50-crema-facial-hidratante/p-16311736/)
- Lookfantastic: €60.95 (https://www.lookfantastic.es/p/clinique-dramatically-different-moisturising-lotion-200ml/13221005/)
Prices checked 15 Oct – 6 Nov 2026.

## Ingredients

Water, Mineral Oil, Paraffinum Liquidum, Huile Minérale, Glycerin, Petrolatum, Stearic Acid, Glyceryl Stearate, Sesamum Indicum Oil, Urea, Lanolin Alcohol, Triethanolamine, Hordeum Vulgare Extract, Extrait Dorge, Cucumis Sativus Fruit Extract, Helianthus Annuus Seedcake Sunflower Seedcake, Propylene Glycol Dicaprate, Sodium Hyaluronate, Butylene Glycol, Pentylene Glycol, Trisodium Edta, Phenoxyethanol, Ci 15985, Yellow 5 Ci 19140, Red 33 Ci 17200
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin