Clé de Peau Beauté Hydro-Clarifying Lotion for skin with dark spots

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Questions and answers

What the research says

• Tremella fuciformis polysaccharides effectively alleviate UVA-induced photodamage in human dermal fibroblasts by reducing ROS and MDA, increasing antioxidant enzyme activities, up-regulating Nrf2 while down-regulating Keap1 expression, and increasing collagen I, elastin, and hyaluronic acid content.

  Journal of Cosmetic Dermatology, 2021

• Tremella fuciformis polysaccharides protect primary human skin keratinocytes and chronic UV-irradiated mouse skin against UV-induced apoptosis, reactive oxygen species production, and cellular damage by regulating thioredoxin interacting protein and thioredoxin reductase 2.

  Photochemical & Photobiological Sciences, 2023

• Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.

  Journal of Pharmacy & Pharmaceutical Sciences, 2015

• A nighttime topical antioxidant containing resveratrol, baicalin, and vitamin E significantly improved fine lines, wrinkles, firmness, elasticity, laxity, hyperpigmentation, radiance, roughness, and dermal thickness in subjects with mild to moderately photodamaged skin over 12 weeks.

  Journal of Drugs in Dermatology, 2014

• Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

  Journal of Cosmetic Dermatology, 2026

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Snow mushroom alcohol-based hand rub gel significantly improved skin moisture better than the placebo through 180 minutes while maintaining comparable antiseptic efficacy in 20 human volunteers.

  Journal of Cosmetic Dermatology, 2021

• Tremella fuciformis extract demonstrates potential cutaneous benefits including skin antiaging, photoprotection, wound healing, and barrier protection based on in vitro and animal models.

  Archives of Dermatological Research, 2023

• Tremella fuciformis inhibits melanogenesis by decreasing melanin content and tyrosinase expression in B16F10 cells while promoting wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts.

  In Vivo, 2022

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Oral and topical botanical products containing ingredients like ashwagandha, saffron, l-theanine, and tocopherol reduced facial redness and pigmentation and improved sleep and certain mood parameters in healthy females with sensitive skin compared to baseline.

  Journal of Clinical Medicine, 2022

• Topical l-theanine pretreatment suppresses TPA-induced acute skin inflammation, ear edema, erythema, vascular permeability, and hyperplasia in mice by downregulating endothelial PECAM-1 and neutrophil infiltration and activation.

  Chemico-biological Interactions, 2018

Ingredients

Water, Dipropylene Glycol, Glycerin, Peg-8, Peg Ppg-14 7 Dimethyl Ether, Trehalose, Butylene Glycol, Xylitol, Phenoxyethanol, Theanine, Peg-60 Hydrogenated Castor Oil, Methylparaben, Hydrogenated Polydecene, Disodium Edta, Erythritol, Isostearyl Alcohol, Isostearic Acid, Sodium Citrate, Dipotassium Glycyrrhizate, Polyquaternium-51, Polyglyceryl-2 Diisostearate, Tremella Fuciformis Polysaccharide, Parfum, Citric Acid, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Angelica Acutiloba Root Extract, Paeonia Albiflora Root Extract, Serine, Glycine, Scutellaria Baicalensis Root Extract, Rosmarinus Officinalis Leaf Water Rosemary Leaf Water, Hydrolyzed Silk, Perilla Ocymoides Leaf Extract, Benzoic Acid, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Fructose, Isodonis Japonicus Stalk Extract Leaf, Hydrolyzed Conchiolin Protein, Tocopherol, Peg-30 Phytosterol, Hydrogenated Lecithin, Trisodium Edta

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.