# Cetaphil Healthy Renew Face Serum for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Cetaphil](https://lovi.care/skincare/es/brands/cetaphil)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your oily skin, as niacinamide and panthenol enhance barrier resilience and provide humectant action, though it lacks targeted ingredients for oil control.
- The formula is generally safe for your oily skin, with no harsh ingredients that would cause irritation.
- While it provides general hydration and soothing effects, the absence of ingredients like salicylic acid or zinc PCA means it does not directly address your concern of oily shine.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin): High

## Key ingredients

Peptides, Niacinamide, Panthenol, Rice Extract Lees Extract, Leontopodium Alpinum Extract

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Daily application of a cream containing niosomes loaded with purple glutinous rice extract in 20 human volunteers for 28 days resulted in a significant decrease in melanin index and skin roughness by -14.05% and -9.95%, and increases in skin hydration and elastic recovery by +48.73% and +35.98% compared to initial values. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32812663/))
- The iontophoretic delivery of hyaluronic acid nanogel-loaded Saccharomyces/Rice Ferment Filtrate significantly reduced advanced glycation end products and mitigated skin stiffening in an ex vivo skin tissue glycation model. ([International Journal of Nanomedicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40989892/))
- Red rice extract suppressed UVB-induced inflammation and skin aging in human skin fibroblasts by inhibiting the MAPK signaling pathway, leading to decreased NF-kappa B and AP-1 activation, reduced ECM degradation, and increased ECM synthesis compared to UVB-irradiated controls. ([Natural Product Communications, 2016](https://pubmed.ncbi.nlm.nih.gov/30508356/))
- Leontopodium alpinum callus culture extract improved anti-periorbital wrinkles, skin elasticity, dermal density, skin thickness, antioxidant activity, and moisturizing activity while suppressing inflammation and wrinkling compared to placebo and in response to UVB treatment. ([Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/))
- Leontopodium alpinum callus culture extract at 10-15 mg/mL promoted COL-I production and inhibited MMP-1, OPN3, ROS, and calcium influx in a blue-light-induced human foreskin fibroblast damage model, indicating an anti-blue-light-damage effect through the OPN3-calcium pathway. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/36903418/))
- A concentrated ethanol extract of Edelweiss callus culture (ECC55) protected primary human keratinocytes and endotheliocytes against various inflammatory and oxidative stimuli by inhibiting chemokine release, restoring sirtuin-inhibited cellular markers, and suppressing inflammation-related gene expression. ([Mediators of Inflammation, 2012](https://pubmed.ncbi.nlm.nih.gov/23093820/))

## Why other serums fit oily skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users with sensitive and aging skin frequently praise this serum as a gentle, effective alternative to retinol that improves skin texture without irritation. Many report a noticeable glow, increased hydration, and softer skin within weeks. Some users feel the anti-aging results are subtle compared to stronger treatments.

- Liked: Gentle on sensitive skin (mostly mentioned)
- Liked: Improves texture and glow (often mentioned)
- Liked: Lightweight and absorbent (often mentioned)
- Liked: Hydrating and softening (sometimes noted)
- Disliked: Packaging and pump issues (sometimes noted)
- Disliked: Small quantity / Low value (sometimes noted)
- Disliked: Lack of dramatic results (rarely noted)
- Disliked: Sticky or tacky finish (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Cetaphil Healthy Renew Face Serum work for oily skin?

Cetaphil Healthy Renew Face Serum works moderately well for oily skin by providing gentle hydration and soothing effects through niacinamide and panthenol, but it lacks targeted ingredients for oil control. Treatments that fit oily skin better need ingredients like salicylic acid, zinc PCA, or ferulic acid to manage excess oil and shine.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for oily skin?

This serum fits oily skin because it contains niacinamide and panthenol, which help strengthen the skin barrier and provide gentle moisture without causing irritation. However, a product for oily skin also needs targeted ingredients like salicylic acid or zinc PCA to directly control excess oil and shine.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What do Peptides do for oily skin?

Peptides help support skin health and may improve the look of oily skin, but this type of skin needs formulas with ingredients that balance oil production and keep pores clear.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for oily skin?

This serum goes in the evening routine, after cleansing and toning and before moisturizing, for simplicity and extra safety around sun exposure. It is safe for oily skin, but an oily skin product also needs ingredients like salicylic acid or zinc PCA to directly address oily shine.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate your skin, followed by your retinol. The gentle and safe formula is unlikely to cause irritation when paired this way.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this serum?

You can use this serum in the evening. Oily skin works best with products that contain oil-controlling ingredients like salicylic acid or zinc PCA.

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to cause breakouts or clog pores on oily skin because it contains no harsh ingredients that would irritate your face. While it provides good moisture and soothing care, oily skin also needs ingredients like salicylic acid or zinc PCA to help control excess shine.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — €169.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — €29.76 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/oily-skin) — Superior fit — €17.49 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Glycerin, Panthenol, 2-Hexanediol, Niacinamide, Cetyl Ethylhexanoate, Hydrogenated Polydecene, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Rice Extract Lees Extract, Leontopodium Alpinum Extract, Calcium Alginate, Propanediol, Hydrolyzed Soy Flour, Ethylhexylglycerin, Agar, Adenosine, Trisodium Ethylenediamine Disuccinate, Synthetic Fluorphlogopite, Caprylyl Glycol, Iron Oxides, Citric Acid, Sodium Benzoate, Potassium Sorbate, Buddleja Davidii Extract, Thymus Vulgaris Extract, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- France: https://lovi.care/skincare/fr/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/oily-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/cetaphil/healthy-renew-face-serum/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/cetaphil/healthy-renew-face-serum/for/oily-skin