# Cetaphil Ceramide Serum for acne-prone skin

**Lovi Fit: Superior fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Cetaphil](https://lovi.care/skincare/es/brands/cetaphil)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for acne-prone skin.

## Why this fit

- Excellent suitability for your combination skin as ceramides, cholesterol, and hyaluronic acid work synergistically to enhance your skin barrier and provide optimal hydration, while panthenol and allantoin soothe inflammation. This formulation effectively addresses your acne and blemishes by delivering essential moisture and calming effects without irritation.
- The presence of ceramides, hyaluronic acid, and panthenol in moderate concentrations ensures effective barrier repair and humectant action, contributing to overall skin health and comfort.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/acne-prone-skin): Superior (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ceramides, Hyaluronic Acid, Glycerin, Phytosphingosine, Cholesterol

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Phytosphingosine demonstrates anti-microbial and anti-inflammatory activity with excellent clinical results in acne vulgaris. ([International Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/18489348/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of an emulsion containing a complete mixture of ceramides III, IIIB, VI, phytosphingosine, cholesterol, and linoleic acid significantly accelerated barrier recovery after SLS damage and improved skin hydration after acetone treatment in human volunteers compared to an emulsion containing only two types of ceramides. ([Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/))
- Phytosphingosine increased filaggrin metabolism and skin hydration in human skin by stimulating filaggrin biosynthesis and degradation leading to natural moisturizing factor formation. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28936777/))
- Phytosphingosine inhibits melanin synthesis in cultured melan-a cells and a reconstructed human skin model by modulating MITF through suppression of gene expression and induction of protein degradation. ([Journal of Dermatological Science, 2017](https://pubmed.ncbi.nlm.nih.gov/28390782/))
- Botulinum toxin-A encapsulated in phosphatidylcholine/cholesterol nanoliposomes delivered transdermally achieved a diffusion depth of 380 μm and showed a nonsignificant advantage in relieving post-acne scarring compared to hyaluronic acid hydrogel treatment in 12 facial patients. ([Journal of Materials Science. Materials in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39073502/))
- Topical application of cholesterol sulfate increases stratum corneum thickness and inhibits protease-induced cell dissociation by competitively inhibiting serine proteases in mice and human stratum corneum. ([The Journal of Investigative Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9699715/))
- Topical lovastatin treatment impairs the recovery of cutaneous permeability barrier function and stratum corneum cholesterol levels after acetone disruption in mice, an effect normalized by simultaneous treatment with mevalonate or cholesterol. ([The Journal of Clinical Investigation, 1990](https://pubmed.ncbi.nlm.nih.gov/2243142/))

## What reviewers say

Users with dry, sensitive, and combination skin praise this serum for its ability to repair the moisture barrier and calm redness without causing irritation. The lightweight, fragrance-free formula is frequently noted for improving skin texture and providing long-lasting hydration, though some users with oily skin find it leaves a slight tackiness.

- Liked: Lightweight & non-greasy (mostly mentioned)
- Liked: Effective hydration (often mentioned)
- Liked: Soothing & gentle (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Price vs. size (sometimes noted)
- Disliked: Insufficient for very dry (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Cetaphil Ceramide Serum one of the best fits for acne-prone skin?

Cetaphil Ceramide Serum is an exceptional fit for acne-prone skin because ceramides, cholesterol, and hyaluronic acid strengthen your skin barrier while panthenol and allantoin soothe inflammation. This combination delivers essential moisture and calming effects without irritation, effectively addressing breakouts while keeping your skin feeling soft and comfortable.
Sources: [International Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/18489348/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because ceramides, cholesterol, and hyaluronic acid strengthen your skin barrier while phytosphingosine and panthenol help calm inflammation and fight blemishes without irritation. These ingredients deliver essential moisture and soothing effects that keep your skin feeling smooth and comfortable.
Sources: [International Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/18489348/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What do Ceramides do for acne-prone skin?

Ceramides help acne-prone skin by restoring a damaged water barrier, reducing dryness and redness from acne treatments, and lowering inflammation. Because acne-prone skin often lacks these key fats, products for this skin type need ceramides to soothe irritation and keep the barrier strong.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [Archives of Dermatological Research, 1995](https://pubmed.ncbi.nlm.nih.gov/7763094/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin calm and hydrated while helping it adjust to the retinol. This product is an excellent fit for acne-prone skin because ceramides, cholesterol, and hyaluronic acid strengthen your skin barrier while panthenol and allantoin soothe inflammation without causing irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### How often should I use this serum?

You can use this serum daily in your evening routine for best results and extra safety around sun exposure. Daily application helps keep your skin calm and hydrated while supporting barrier health without irritation.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on acne-prone skin because it avoids harsh ingredients and includes soothing components that calm inflammation. Its formulation delivers essential moisture without irritation, making it an excellent fit for keeping your skin clear and comfortable.
Sources: [International Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/18489348/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum around the eyes or on my body?

You can use this serum around your eyes and on your body because its gentle blend of moisturizers and calming ingredients is safe for delicate skin. The skin around the eyes and on certain body areas is very thin, so soothing formulas like this help keep it soft and comfortable without causing irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/es/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/acne-prone-skin) — Superior fit — €6.30 at Notino
- [SkinCeuticals Hydrating B5 Gel](https://lovi.care/skincare/es/p/skinceuticals/hydrating-b5-gel/for/acne-prone-skin) — High fit — €101.20 at Lookfantastic
- [SK-II LXP Ultimate Revival Essence](https://lovi.care/skincare/es/p/sk-ii/ultimate-revival-essence/for/acne-prone-skin) — High fit — €347.00 at Notino

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- SPF: [SKIN1004 Madagascar Centella Air-Fit Suncream Plus](https://lovi.care/skincare/es/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/acne-prone-skin) — Superior fit — €12.94 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Cetearyl Alcohol, Ceteareth-20, Ceramide Np, Ceramide Ap, Ceramide Eop, Phytosphingosine, Cholesterol, Hyaluronic Acid, Tocopheryl Acetate, Panthenol, Allantoin, Xanthan Gum, Carbomer, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cetaphil/ceramide-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/cetaphil/ceramide-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/cetaphil/ceramide-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/cetaphil/ceramide-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/cetaphil/ceramide-serum/for/acne-prone-skin