Biossance Squalane + Ectoin Overnight Rescue for acne-prone skin
Squalane
Ectoin
Glycerin
Shorea Stenoptera Seed Butter
Acetyl Hexapeptide-8
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for acne-prone skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate moisturizing for your combination skin, as squalane and glycerin hydrate and enhance barrier resilience, though it lacks stronger ingredients for oil control.
- The formula provides general skincare benefits supportive for acne-prone skin, but it does not contain targeted ingredients to effectively address acne, blemishes, and breakouts.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like ectoine and glycerin.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
People Say
★4.6Overall rating based on 2.0k+ reviewsMost users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.
Highlights
Deeply hydrating Mostly Mentioned
- “My skin loves and drinks this right up.”
- “It keeps my face hydrated until morning.”
- “This is the first cream that has helped with my dry skin.”
- “Hydrates me very well overnight.”
Absorbs well Often Mentioned
- “Absorbs right in without the need to overly blend it in.”
- “It is not greasy at all like serums can be.”
- “Melts into your skin so easily and effortlessly.”
- “Absorbs quickly and leaves no greasy residue or film.”
Plumps and softens Often Mentioned
- “Wake up with plump, moisturized, healthy-looking skin.”
- “Makes my skin look super plump, glowing, and helps it to feel very soft.”
- “I wake up in the morning to baby smooth skin.”
- “Always makes my skin feeling so soft as soon as I put it on.”
Soothes sensitive skin Often Mentioned
- “There is no stinging, irritation or redness when using this product.”
- “I have very sensitive skin and this has been great for my skin.”
High price point Sometimes Noted
- “Seventy dollars for one small jar is a steep ask.”
- “Seventy dollars buys a single fifty-milliliter jar.”
- “Asks you to pay a premium.”
Heavy or greasy Rarely Noted
- “Consistency leaves a greasy feel to the skin.”
- “The overnight rescue is by far one of the thickest creams I have ever used.”
- “Heaviness, or a greasy feel may occur for some users.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Jar packaging Rarely Noted
- “As always, a jar means scooping.”
- “Which is a small hygiene knock.”
- “The frosted glass jar is attractive but... a jar means scooping.”
May cause breakouts Rarely Noted
- “A few reviews mention that breakouts... may occur for some users.”
- “Not formulated to be fungal-acne safe.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Sources: lovi.care, sephora.com, biossance.com, influenster.com, dermapproved.com, cultbeauty.co.uk, and more
Questions and answers
How well does Biossance Squalane + Ectoin Overnight Rescue work for acne-prone skin?
Biossance Squalane + Ectoin Overnight Rescue works reasonably well for acne-prone skin, providing moderate hydration and a safe profile without harsh ingredients, though it lacks targeted components to manage breakouts. Acne-prone skin requires products that combine oil control and targeted blemish-fighting ingredients alongside soothing hydration.
Which ingredients make this cream a good fit for acne-prone skin?
Squalane, glycerin, and ectoin make this cream a good fit by providing gentle hydration and calming dry areas without causing irritation. However, acne-prone skin needs targeted ingredients to effectively address breakouts and control oil.
What does Squalane do for acne-prone skin?
Squalane may help keep acne-prone skin soft and smooth, but peroxidated forms can trigger inflammation in skin cells. For a better fit on acne-prone skin, products need non-clogging, soothing ingredients that balance oil without causing irritation.
What does Ectoin do for acne-prone skin?
Ectoin helps acne-prone skin by acting as a protective agent that calms irritation and strengthens the skin barrier. It is unlikely to clog pores and may help keep skin smooth and comfortable while you manage breakouts. Acne-prone skin of this type needs lightweight hydrators and soothing ingredients to balance moisture without feeling heavy or greasy.
Clinics in Dermatology, 2008Arhiv Za Higijenu Rada I Toksikologiju, 2016
Where does it go in a skincare routine for acne-prone skin?
This moisturizing treatment goes in the evening routine as the final step after your treatment serum. This type of product works for acne-prone skin by providing gentle hydration, but to properly manage blemishes it needs targeted ingredients for oil control and breakouts.
Can I use this cream with retinol, and in what order?
You can use this moisturizing treatment with retinol to keep your skin soft and calm while reducing dryness. Apply your retinol first, let it absorb, and then smooth on this cream to help buffer potential irritation.
How often should I use it?
You can use this moisturizing treatment in your evening routine, applying it daily as your last step or after your serum. Daily application of moisturizers of this type helps keep skin soft and supports barrier function.
Health Science Reports, 2021Journal of Cosmetic Dermatology, 2020
Can this cream clog pores, cause breakouts or purging for acne-prone skin?
This cream is unlikely to cause breakouts or clog pores on acne-prone skin, as it has a very low risk of heavy or greasy feel and contains soothing ingredients like ectoin and glycerin. However, because it lacks targeted ingredients for oil control and blemishes, acne-prone skin needs a product with specialized blemish-fighting ingredients.
Can I use it around the eyes or on my body?
This product is safe to use around the eyes and on the body, though it is formulated primarily as a facial moisturizing treatment. Because the skin on the eyelids is among the thinnest on the entire body, gentle and well-tolerated formulas like this one are well-suited for delicate areas without causing irritation.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas.
Journal of Cosmetic Dermatology, 2024Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control.
Biomedicines, 2026Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance.
Polymers, 2023The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017
Why other moisturizers fit acne-prone skin better
Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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