# Biossance Squalane + Copper Peptide Rapid Plumping Serum for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Biossance](https://lovi.care/skincare/es/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- This serum offers excellent plumping and hydration for your oily skin, with squalane and sodium hyaluronate improving elasticity and balancing moisture without exacerbating oiliness.
- While beneficial for general skin health, the formula's primary focus is not on directly addressing your acne, blemishes, and breakouts.
- The product is safe for your skin, featuring soothing ingredients like Ectoin and Aloe Barbadensis Flower Extract that prevent irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Squalane, Copper Peptides, Sodium Hyaluronate, Acmella Oleracea Extract, Panthenol

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))

## What reviewers say

Based on a very large amount of data, this serum is widely praised for its ability to deliver instant hydration and a visible plumping effect, making it a favorite for users with dry, dehydrated, or aging skin. The majority of users report a lightweight texture that absorbs well and improves skin bounce. A minority experience stickiness or find the high price point unjustifiable for the results achieved.

- Liked: Intense hydration (mostly mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Visible plumping (often mentioned)
- Liked: Improved texture (sometimes noted)
- Liked: Soothing properties (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Paradoxical drying (rarely noted)
- Disliked: Sticky after-feel (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Copper Peptide Rapid Plumping Serum a great fit for oily acne-prone skin?

This serum is a great fit for your oily skin because it uses squalane and sodium hyaluronate to improve elasticity and balance moisture without making your face greasy. It also includes soothing ingredients like Ectoin and aloe flower that help prevent irritation and keep your skin calm.

### Which ingredients make this serum a good fit for oily acne-prone skin?

Squalane and sodium hyaluronate make this serum a great fit for your oily skin by balancing moisture and improving elasticity without making you greasy. Soothing ingredients like ectoin and aloe flower extract are also included, which help prevent irritation.

### What does Squalane do for oily acne-prone skin?

Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### What do Copper Peptides do for oily acne-prone skin?

Copper peptides help calm oily, acne-prone skin by reducing redness and soothing inflammation while supporting the skin barrier. They are unlikely to clog pores and may improve overall skin texture.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/29986520/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine as a treatment step before your moisturizer. It helps balance moisture on oily skin without clogging pores, while soothing ingredients like ectoine and aloe flower may help prevent irritation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate your skin and then following with your retinol. Using a moisturizing treatment with barrier-supporting ingredients may help reduce the dryness and irritation often caused by retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

This serum is used in the evening as part of your routine. It helps balance moisture and improve elasticity without making your oily skin feel greasy, and includes soothing ingredients that are unlikely to cause irritation.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit and is unlikely to cause breakouts or clog pores on oily acne-prone skin. It balances moisture without making your skin oily, and it features soothing ingredients that help prevent irritation.

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes, where the skin is particularly thin, as it provides safe hydration and plumping with a very good skin tolerance. While you can apply it on your body, its targeted formula is mainly designed for facial use to improve elasticity and balance moisture without feeling heavy.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/oily-acne-prone-skin) — High fit — €39.50 at Notino
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/es/p/missha/super-aqua-ultra-hyalron-ampoule/for/oily-acne-prone-skin) — Average fit — €20.00 at Notino

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- SPF: [Dear, Klairs All-day Airy Sunscreen](https://lovi.care/skincare/es/p/dear-klairs/all-day-airy-sunscreen/for/oily-acne-prone-skin) — Superior fit — €21.00 at Amazon

## Where to buy

- Lookfantastic: €47.44 (https://www.lookfantastic.es/p/biossance-squalane-and-copper-peptide-rapid-plumping-serum-50ml/13643574/)
Prices checked 17 Oct 2026.

## Ingredients

Water, Glycerin, Propanediol, Squalane, Sodium Hyaluronate, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Copper Tripeptide-1, Acmella Oleracea Extract, Ectoin, Tetrapeptide-30, Palmitoyl Hexapeptide-52, Copper Pca, Panthenol, Sodium Polyglutamate, Camellia Sinensis Leaf Extract, Aloe Barbadensis Flower Extract, Passiflora Incarnata Flower Extract, Melia Azadirachta Leaf Extract, Solanum Melongena Fruit Extract, Curcuma Longa Root Extract, Ocimum Basilicum Leaf Extract Flower, Coccinia Indica Fruit Extract, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
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- France: https://lovi.care/skincare/fr/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin
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