# AXIS-Y Spot The Difference Blemish Treatment for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [AXIS-Y](https://lovi.care/skincare/es/brands/axis-y)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers excellent treatment for blemishes on your combination skin due to salicylic acid and glycolic acid, which effectively exfoliate and decongest pores to manage oily shine.
- The formulation is well-suited for your combination skin type, regulating desquamation and providing moderate exfoliation without causing irritation.
- The safety profile is excellent, with soothing ingredients like Centella Asiatica Extract and Aloe Barbadensis Leaf Extract ensuring no risks of irritation for your skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Salicylic Acid Bha, Glycolic Acid Aha, 4-Terpineol, Ceramide Np

## What the research says

- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- The use of a salicylic acid-based dermocosmetic significantly reduces the needed quantity of benzoyl peroxide without impacting efficacy in mild to moderate acne, and as maintenance post-benzoyl peroxide allows a significant reduction of acne relapse compared to vehicle. ([Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- A foam formulation of 2% 4-terpineol killed common ocular microorganisms within 60 seconds and at 14 and 28 days without causing skin or ocular irritation in human subjects. ([BMJ Open Ophthalmology, 2018](https://pubmed.ncbi.nlm.nih.gov/30123842/))
- Topical tea tree oil and terpinen-4-ol produce good clinical outcomes in the management of Demodex blepharitis. ([Cornea, 2022](https://pubmed.ncbi.nlm.nih.gov/34743107/))
- Topical treatment with Australian tea tree oil and terpinen-4-ol effectively moderates human demodicosis by lowering mite counts, relieving symptoms, and modulating the inflammatory immune response. ([Parasitology, 2018](https://pubmed.ncbi.nlm.nih.gov/29667560/))

## What reviewers say

Users with acne-prone, oily, and sensitive skin praise this lightweight gel for effectively reducing redness and calming active breakouts without drying out the skin. While many experience fast results and appreciate the hydrating ceramide capsules, some find the bottle size too small and note that it may take time to see significant changes on stubborn blemishes.

- Liked: Gentle & non-drying (mostly mentioned)
- Liked: Effective acne relief (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Small product size (often mentioned)
- Liked: Good for sensitive skin (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Absorption issues (rarely noted)
- Disliked: Scent/applicator (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes AXIS-Y Spot The Difference Blemish Treatment a great fit for combination skin?

This treatment is a great fit because salicylic acid and glycolic acid clear out pores and keep oily shine under control. Soothing ingredients like Centella Asiatica and aloe help keep the skin calm and comfortable without irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Which ingredients make this treatment a good fit for combination skin?

Salicylic acid and glycolic acid make this treatment a great fit by exfoliating and clearing pores to manage oily shine. Soothing ingredients like Centella asiatica extract and aloe vera help ensure it provides moderate exfoliation safely without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Salicylic Acid do for combination skin?

Salicylic acid helps clear clogged pores and balance oily areas while remaining gentle enough for dry spots on combination skin. It reduces breakouts and oiliness effectively with a low likelihood of irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in your evening routine, as treatments with active ingredients are placed at night for simplicity and extra safety around sun exposure. Soothing ingredients like Centella Asiatica extract help ensure a very low risk of irritation while managing blemishes.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol, but apply them on alternating nights to keep your skin calm and smooth. Using both strong ingredients at the same time may lead to dryness or irritation.

### How often should I use this treatment?

You can use this treatment in your evening routine, starting once a week to see how your skin responds. If your skin handles it well, you may carefully use it more often.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to clog pores or cause breakouts for your combination skin because salicylic acid and glycolic acid clear out pores while soothing ingredients like centella asiatica and aloe vera help calm the skin.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €333.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €169.99 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — €97.52 at Amazon

## Where to buy

- Amazon.de: €10.85 (https://www.amazon.de/dp/B09HX96NKV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €15.00 (https://www.lookfantastic.es/p/axis-y-spot-the-difference-blemish-treatment-15ml/17735051/)
Prices checked 14 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Propanediol, 1,2-Hexanediol, Glycereth-26, Niacinamide, Caprylic Capric Triglyceride, Aloe Barbadensis Leaf Extract, Althaea Rosea Flower Extract, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Camellia Sinensis Leaf Extract, Monarda Didyma Leaf Extract, Hydrangea Macrophylla Leaf Extract, Mentha Aquatica Extract, Sasa Quelpaertensis Extract, Melaleuca Alternifolia Tree Leaf Extract, Melia Azadirachta Leaf Extract, Eclipta Prostrata Extract, Camphor Leaf Extract, Cryptomeria Japonica Leaf Extract, Pinus Pinaster Bud Extract Bark, Rosmarinus Officinalis Oil Leaf Rosemary Oil Leaf, Hydrogenated Lecithin, Chamaecyparis Obtusa Water, Trehalose, Octyldodeceth-16, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, C12-14 Pareth-12, Butylene Glycol, Xanthan Gum, Disodium Edta, Ceramide Np, Fructooligosaccharides, Beta-Glucan, Hydrolyzed Hyaluronic Acid, 4-Terpineol, Glycyrrhiza Glabra Root Rhizome Licorice Root Rhizome, Moringa Oleifera Seed Oil, Glycolic Acid, Salicylic Acid, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- France: https://lovi.care/skincare/fr/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin