# AXIS-Y Artichoke Intensive Skin Barrier Ampoule for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [AXIS-Y](https://lovi.care/skincare/es/brands/axis-y)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for normal skin, as glycerin and sodium hyaluronate provide humectant action for hydration, but it lacks sufficient emollients for complete nourishment.
- The ampoule provides excellent moisturizing and barrier support with sodium hyaluronate and beta-glucan, which hydrate and enhance barrier resilience.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Cynara Scolymus Extract, Sodium Hyaluronate, Centella Asiatica Extract, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of an aqueous gel containing 0.1% w/w naringenin demonstrated in vitro safety, significantly reduced UV-induced stratum corneum lipid peroxidation, and showed in vivo anti-inflammatory efficacy against methyl nicotinate-induced inflammation in human participants compared to a blank gel and untreated area, while chlorogenic acid, apigenin, and kaempferol displayed pro-oxidant profiles. ([Frontiers in Chemistry, 2024](https://pubmed.ncbi.nlm.nih.gov/38831914/))
- An artichoke extract cosmetic formulation enhanced skin roughness by 19.74% and elasticity by 11.45% in human subjects compared to a placebo cream, alongside exhibiting antioxidant, anti-inflammatory, and anti-aging cellular effects. ([Molecules, 2018](https://pubmed.ncbi.nlm.nih.gov/30360471/))
- Luteolin inhibited the mRNA expression of antimicrobial peptides and increased cornified envelope proteins in TNF-alpha/IL-17A/IFN-gamma-stimulated HaCaT cells by regulating the TRAF6/IkappaB/NF-kappaB signaling pathway. ([Food Science and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40655288/))
- Antioxidants and luteolin topically applied decrease UV-B induced apoptosis and downregulate pro-inflammatory cytokines in kindler syndrome keratinocyte cultures. ([Human Molecular Genetics, 2016](https://pubmed.ncbi.nlm.nih.gov/27798104/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))

## Why other moisturizers fit mature skin better

- Daily consumption of fermented pomegranate extract drinks and serums improved skin moisture, brightness, elasticity, and collagen density while reducing spots in healthy subjects compared to baseline. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34416060/))
- Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo. ([Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38606717/))
- Aged Punica granatum extract significantly reduced UV-induced erythema and melanin levels while improving skin hydration and lightness compared to placebo in 60 women. ([Food Science & Nutrition, 2025](https://pubmed.ncbi.nlm.nih.gov/40755496/))

## What reviewers say

This ampoule is widely praised as a lightweight, fast-absorbing treatment that excels at soothing irritated skin and repairing a damaged moisture barrier, particularly for oily, acne-prone, and sensitive skin types. Users frequently note that while it provides excellent hydration and redness relief without stickiness, those with very dry skin often need to layer it with a heavier moisturizer.

- Liked: Soothing & calming (mostly mentioned)
- Liked: Hydrating (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Small size/price (sometimes noted)
- Disliked: Alcohol content (rarely noted)
- Disliked: Breakouts/reaction (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does AXIS-Y Artichoke Ampoule work for mature skin?

This ampoule works moderately well for mature skin because it hydrates with sodium hyaluronate and glycerin, but it lacks sufficient richer softening ingredients for complete nourishment. A product for mature skin needs deeper nourishment and targeted anti-aging actives to truly optimize results.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

This moisturizing treatment works for mature skin because sodium hyaluronate and glycerin help pull in moisture while beta-glucan supports skin barrier strength. To be a better fit for mature skin, this type of product needs extra nourishing emollients and specific anti-wrinkle actives like peptides.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Artichoke Extract do for mature skin?

Artichoke extract helps smooth out rough patches and makes mature skin feel firmer and more elastic. It may also provide antioxidant and anti-aging benefits to support overall skin health.
Sources: [Molecules, 2018](https://pubmed.ncbi.nlm.nih.gov/30360471/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine before your moisturizer. Mature skin needs rich nourishing ingredients and richer emollients to fully support it.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate your skin before following with retinol. This type of product needs rich nourishing ingredients and protective oils to properly support mature skin.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in your evening routine for simplicity and extra safety around sun exposure. A product of this type needs rich moisturizing ingredients and oils to keep mature skin properly nourished and smooth.

### Can this serum clog pores, cause breakouts or purging for mature skin?

AXIS-Y Artichoke Intensive Skin Barrier Ampoule is unlikely to clog pores or cause breakouts for mature skin, as it has an excellent safety profile without harsh ingredients. However, because it provides only moderate moisture, mature skin usually needs richer creams with added nourishing oils to stay fully soft and smooth.

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, as it has a very safe formula with no harsh ingredients. However, mature skin needs a product of this type to include rich smoothing oils and butters for complete nourishment.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for mature skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/es/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/mature-skin) — High fit — €6.30 at Notino

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Bioré UV Perfect Milk SPF 50+ PA++++](https://lovi.care/skincare/es/p/biore/uv-face-milk-spf50-pa/for/mature-skin) — Superior fit — €25.88 at Amazon

## Where to buy

- Amazon.de: €16.00 (https://www.amazon.de/dp/B08CBP84MR?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Aloe Barbadensis Leaf Water, Butylene Glycol, Sodium Hyaluronate, Centella Asiatica Extract, Glycerin, Betaine, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Alcohol, Cynara Scolymus Extract, Sorbitol, Sorbitan Sesquioleate, Hieracium Pilosella Extract, Rheum Palmatum Root Extract, Althaea Rosea Flower Extract, Aloe Barbadensis Leaf Extract, Dimethyl Sulfone, Chlorphenesin, Xanthan Gum, Peg-60 Hydrogenated Castor Oil, Ethylhexylglycerin, Polyglutamic Acid, Beta-Glucan, Arginine, Linum Usitatissimum Seed Extract, Hibiscus Esculentus Fruit Extract, Aloe Barbadensis Leaf Juice, Arctium Lappa Root Extract, Hibiscus Mutabilis Flower Extract, Corchorus Olitorius Leaf Extract, Allantoin, Carbomer, Adenosine, Melaleuca Alternifolia Tree Oil Leaf
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin