# Avène Cleanance Comedomed Anti-Blemish Concentrate for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Avène](https://lovi.care/skincare/es/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for your acne-prone skin as isopropyl alcohol and silybum marianum fruit extract help reduce acne lesions and blemishes, while also providing excellent suitability for your oily skin through seboregulation and mild astringent effects.
- Avène Thermal Spring Water further soothes your skin, contributing to a balanced and comfortable experience.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Avène Thermal Spring Water, Silybum Marianum Fruit Extract, Glycerin, Isopropyl Alcohol, Silica

## What the research says

- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- A formulation containing vitamin C, biopeptides, hyaluronic acid, and mineralizing water accelerated cell turnover to 17.1 days versus 19.2 days for untreated skin, and reduced crow's-feet, forehead, and nasolabial folds by 9%, 11%, and 5% respectively after 28 days in female subjects. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/33038010/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers. ([The Journal of Bone and Joint Surgery. American Volume, 2005](https://pubmed.ncbi.nlm.nih.gov/15866960/))
- Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38826967/))
- Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis. ([Skinmed, 2016](https://pubmed.ncbi.nlm.nih.gov/27871345/))
- A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities. ([Antioxidants, 2020](https://pubmed.ncbi.nlm.nih.gov/32224894/))
- Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers. ([European Journal of Pharmaceutical Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/28546105/))
- Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18312388/))

## What reviewers say

Based on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Reduces blemishes (mostly mentioned)
- Disliked: Strong alcohol scent (mostly mentioned)
- Liked: Controls oil (often mentioned)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying or peeling (sometimes noted)
- Disliked: Initial skin purging (rarely noted)
- Disliked: Stinging sensation (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Avène Cleanance Comedomed work for oily acne-prone skin?

Avène Cleanance Comedomed Anti-Blemish Concentrate works moderately well for oily acne-prone skin, as it helps reduce blemishes and control excess oil while soothing your skin with a very low risk of irritation. To fit this skin type even better, a treatment needs effective ingredients like niacinamide, propolis, or vitamin C that provide balanced hydration and targeted acne care without heavy components.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### Which ingredients make this treatment a good fit for oily acne-prone skin?

Isopropyl alcohol and silybum marianum fruit extract make this treatment a fit by helping reduce acne lesions and blemishes while balancing your oily skin. Treatments that fit this skin best also need effective ingredients like niacinamide and propolis, along with antioxidants and hydrating agents that control excess oil and keep skin comfortable.

### What does Avène Thermal Spring Water do for oily acne-prone skin?

Avène Thermal Spring Water helps calm oily acne-prone skin by reducing dryness and stinging when used alongside standard acne treatments. It also has a very safe profile that makes it comfortable for sensitive skin.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### What does Milk Thistle Fruit Extract do for oily acne-prone skin?

Milk thistle fruit extract helps calm oily, acne-prone skin by reducing both inflamed breakouts and clogged pores while keeping the skin comfortable. It may also improve overall skin clarity and texture with minimal irritation.
Sources: [Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/), [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38564394/)

### Where does it go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, as Lovi routines put treatments in the evening for simplicity and extra safety around sun exposure. To care for this skin even better, an oily acne-prone product needs ingredients like salicylic acid, niacinamide, or retinoids to clear pores and balance oil more effectively.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first and following with your moisturizer before adding a retinol product on separate nights to keep your skin calm and comfortable.

### How often should I use it?

You can use this treatment in your evening routine, applying it after cleansing and before moisturizing. This product of this type needs balancing hydration and soothing ingredients to effectively manage acne while keeping your oily skin comfortable.

### Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment is unlikely to clog pores, but initial breakouts and mild peeling may happen as it works on your acne-prone skin. A product of this type needs ingredients that clear blemishes and balance oil without causing irritation.

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (isopropyl alcohol).

## Alternatives for oily acne-prone skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €29.76 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €29.76 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €20.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- SPF: [Dear, Klairs All-day Airy Sunscreen](https://lovi.care/skincare/es/p/dear-klairs/all-day-airy-sunscreen/for/oily-acne-prone-skin) — Superior fit — €21.00 at Amazon

## Where to buy

- Amazon.de: €15.19 (https://www.amazon.de/dp/B0FGK543DF?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €18.90 (https://www.notino.es/avene/cleanance-comedomed-cuidado-intensivo-para-imperfecciones-de-la-piel-con-acne/p-16322754/)
- Lookfantastic: €19.79 (https://www.lookfantastic.es/p/avene-cleanance-comedomed-intensive-anti-blemish-care-30ml/17308720/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin