# APLB Glutathione Niacinamide Ampoule Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [APLB](https://lovi.care/skincare/es/brands/aplb)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- This serum offers moderate brightening and evening of skin tone for your combination skin, as niacinamide and ascorbic acid work to address dullness and discoloration. Centella Asiatica Extract and Sodium Hyaluronate provide supportive hydration and soothing benefits, which can help manage oily shine.
- The formula is highly suitable for combination skin due to the presence of niacinamide and centella asiatica extract, offering seboregulation and anti-inflammatory action.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the inclusion of soothing agents like Centella Asiatica Extract and Dipotassium Glycyrrhizate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/oily-acne-prone-skin): High

## Key ingredients

Glutathione, Niacinamide, Centella Asiatica Extract, Sodium Hyaluronate, Squalane

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Based on a very large amount of data, users with sensitive, acne-prone, and combination skin frequently praise this serum for its lightweight, non-sticky hydration and ability to calm redness while gradually evening out skin tone. While it effectively delivers a "glass skin" glow and smooths texture, many users note that brightening hyperpigmentation is a slow process requiring consistent long-term use.

- Liked: Lightweight & absorbent (mostly mentioned)
- Liked: Brightens skin tone (often mentioned)
- Liked: Soothes sensitive skin (often mentioned)
- Liked: Hydrating & plumping (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Cheap packaging feel (rarely noted)
- Disliked: Insufficient for dryness (rarely noted)
- Disliked: Rare skin irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does APLB Glutathione Niacinamide Ampoule Serum work for combination skin?

This serum works moderately well for your combination skin, offering basic brightening and soothing hydration that helps manage oily shine. A treatment of this type needs effective ingredients like niacinamide and propolis or zinc PCA that regulate oiliness, enhance radiance, and provide optimal hydration and balance without excess oiliness or dryness.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for combination skin?

Niacinamide and centella asiatica extract make this serum a good fit for combination skin by helping manage oily shine while providing soothing benefits. To match the best fits for combination skin, this type of product also needs ingredients like propolis or zinc PCA to regulate oiliness and enhance radiance without causing irritation or imbalance.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Glutathione do for combination skin?

Glutathione helps brighten sun-exposed areas and reduce dark spots for combination skin, while also improving moisture and smoothness. It is unlikely to cause irritation and maintains a safe profile for regular use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [International Journal of Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39444151/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Combination skin needs products with ingredients like niacinamide and lightweight hydrators to balance oil and add moisture without feeling heavy.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol treatment. A combination product of this type for your combination skin needs ingredients like niacinamide and centella asiatica extract to manage oily shine while keeping the skin calm.

### How often should I use this serum?

This serum works well as an evening treatment for your combination skin. To get better results for this skin type, a product of this type needs balancing ingredients like niacinamide to control oily shine along with soothing hydrators like centella asiatica extract.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts or clog pores for your combination skin. Its safe formula includes soothing agents like Centella Asiatica Extract and Dipotassium Glycyrrhizate, which help keep skin calm without heavy oils.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €333.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €169.99 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — €97.52 at Amazon

## Where to buy

- Amazon.de: €11.99 (https://www.amazon.de/dp/B0C2P4LLXX?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Centella Asiatica Extract, Butylene Glycol, Propanediol, Glycerin, Diethoxyethyl Succinate, Panthenol, Sodium Hyaluronate, Allantoin, Sodium Polyacryloyldimethyl Taurate, Glyceryl Acrylate Acrylic Acid Copolymer, Nelumbo Nucifera Extract, Artemisia Annua Extract, Rice Extract, Saccharomyces Ferment, Solanum Melongena Fruit Extract, Melaleuca Alternifolia Tree Leaf Extract, Hydrolyzed Collagen, Squalane, Beta-Glucan, Ascorbic Acid, Dipropylene Glycol, Hippophae Rhamnoides Fruit Extract, Adenosine, Madecassic Acid, Asiaticoside, Asiatic Acid, Caprylic Capric Triglyceride, Hydrogenated Lecithin, Glyceryl Stearate, Cholesterol, Styrene Acrylates Copolymer, Cellulose Gum, Xanthan Gum, Inulin, Cellulose, Glucose, Fructose, Citric Acid, Disodium Edta, Hydroxyacetophenone, 1,2-Hexanediol, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Sodium Citrate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin